A novel mitochondrial DNA tRNAIle (m.4322dupC) mutation associated with idiopathic dilated cardiomyopathy [0.03%]
与特发性扩张型心肌病相关的线粒体DNA tRNAIle (m.4322dupC) 新突变
Sinda Mahjoub,Damien Sternberg,Rafik Boussaada et al.
Sinda Mahjoub et al.
We identified a novel heteroplasmic mitochondrial DNA (mtDNA) (m.4322dupC) mutation in tRNA gene associated with isolated dilated cardiomyopathy (DCM) as maternal trait. Mutation screening techniques and automated DNA sequencing were perfor...
Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies [0.03%]
胰腺腺癌中异质性 Hedgehog 通路表达：对临床活检标本进行分子分析的启示
Adam Steg,Selwyn M Vickers,Mohamad Eloubeidi et al.
Adam Steg et al.
Recent studies suggest that hedgehog (HH)-pathway signaling is required for the initiation and continued growth of pancreatic adenocarcinoma (PAC). Definitive gene expression analysis of PAC remains difficult, owing to the host desmoplastic...
The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas [0.03%]
Snail——E-钙黏素的抑制因子在子宫内膜样腺癌中的作用
Kareen Blechschmidt,Elisabeth Kremmer,Regina Hollweck et al.
Kareen Blechschmidt et al.
Endometrial cancer is the most common gynecologic cancer in the developed world. The cell-adhesion protein E-cadherin acts as a tumor-suppressor protein and is down-regulated by the transcription factor Snail, whose expression was shown to ...
Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis [0.03%]
喉部鳞状细胞癌早晚期分子分型的探索性分析
Ozlen Saglam,Veena Shah,Maria J Worsham
Ozlen Saglam
Background: A current shortcoming in cancer prognostication and treatment is a lack of methods that adequately address the complexity and diversity of the disease. Prognostic marker systems based on single parameters have...
Molecular and immunohistochemical analysis of ERBB2 expression in correlation with proliferation rate in synovial sarcoma [0.03%]
分子和免疫组化分析ERBB2表达与滑膜肉瘤增殖速率的相关性
Lenka Krsková,Marketa Kalinová,Helena Brizová et al.
Lenka Krsková et al.
The aim of the study was to determine whether or not the tyrosine kinase receptor ERBB2 is overexpressed in synovial sarcomas (SSs). We also focused on the cell cycle-related nuclear protein-Ki-67. Thirty-two samples were available for immu...
Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 Status in adenocarcinoma of the breast: a single institution experience [0.03%]
荧光原位杂交技术作为主要方法评估乳腺腺癌HER2状态：单一机构经验报告
Raymond R Tubbs,David G Hicks,James Cook et al.
Raymond R Tubbs et al.
The demand for both reflexed and primary fluorescence in-situ hybridization (FISH) testing in the clinical setting is increasing. Relevant literature has reported the incidence of HER2 overexpression in 20% to 30% of cases, but some reports...
Evaluation of whole genome amplification protocols for array and oligonucleotide CGH [0.03%]
评估全基因组扩增方案用于阵列和寡核苷酸 comparative genomic hybridization (CGH)
Adam Hittelman,Shivaranjani Sridharan,Ritu Roy et al.
Adam Hittelman et al.
Genome-based technologies such as genomic arrays and next generation sequencing are poised to make significant contributions to clinical oncology. However, translation of these technologies to the clinic will require that they produce high-...
Global expression analysis of prostate cancer-associated stroma and epithelia [0.03%]
与前列腺癌相关的间质和上皮的全局表达分析
Annely M Richardson,Karen Woodson,Yonghong Wang et al.
Annely M Richardson et al.
Characterization of gene expression profiles in tumor cells and the tumor microenvironment is an important step in understanding neoplastic progression. To date, there are limited data available on expression changes that occur in the tumor...
CYP2C9 and VKORC1 genetic polymorphism analysis might be necessary in patients with Factor V Leiden and prothrombin gene G2021A mutation(s) [0.03%]
对于存在FV莱顿因子突变和凝血酶原基因G2021A突变的患者，有必要分析CYP2C9和VKORC1的遗传多态性
Allen Leung,Chih-Kang Huang,Riho Muto et al.
Allen Leung et al.
The annual incidence of venous thromboembolism is approximately 117 per 100,000 persons or about 1 per 1000 person-years, with the majority of the disease occurring in the older age groups. Factor V Leiden gene (most common) and the prothro...
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma [0.03%]
SYT-SSX1融合基因新变异体一例报告
Lenka Krsková,David Sumerauer,Eva Stejskalová et al.
Lenka Krsková et al.
Synovial sarcoma (SS) is a rare soft-tissue tumor that affects children and young adults. It is characterized by chromosomal translocation t(X;18)(p11.2;q11.2), which results in the fusion of the gene SYT on chromosome 18 with SSX genes on ...