Evaluation of 3 methods of whole-genome amplification for subsequent metaphase comparative genomic hybridization [0.03%]
Grace Ng,Ian Roberts,Nicholas Coleman
Grace Ng
A common aim in cancer research is to investigate mechanisms of malignant progression by genetic analysis of key stages, including pre-malignancy, microinvasion, and micrometastases. As such lesions are small and require microdissection fro...
Molecular genetic testing of polymorphisms associated with venous thrombosis: a review of molecular technologies [0.03%]
Bo Xu,Raymond R Tubbs,Kandice Kottke-Marchant
Bo Xu
The growing knowledge of genetic polymorphisms predisposing to venous thrombosis has increased the demand for genetic testing of associated risk factors. This has prompted the need for simple, fast, reliable, and cost-effective genotyping m...
DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests [0.03%]
粪便DNA结直肠癌检测中DNA稳定性对检测性能的影响不容忽视
Jeff Olson,Duncan H Whitney,Kristine Durkee et al.
Jeff Olson et al.
We have developed a multitarget, fecal DNA screening assay that detects the presence of gene-specific mutations and long DNA fragments associated with colorectal cancer (CRC). We continue to investigate methods that may be used to optimize ...
Quantitative real-time PCR for quick simultaneous determination of therapy-stratifying markers MYCN amplification, deletion 1p and 11q [0.03%]
用于快速同时确定治疗分层标志物MYCN扩增、1P缺失和11q的定量实时PCR方法研究
Marc Boensch,André Oberthuer,Matthias Fischer et al.
Marc Boensch et al.
Amplification of the oncogene MYCN as well as deletions in 1p and 11q are important prognostic and in part therapy-stratifying factors in human neuroblastoma. Due to the increasing clinical relevance of these molecular markers, accurate and...
Application of a fluorescent PCR method for molecular diagnosis of posttransplant lymphoproliferative disorders on routine tissue sections [0.03%]
荧光PCR方法在移植后淋巴增生性疾病病理组织常规切片检测中的应用研究
Elisa Gruppioni,Barbara Corti,Annalisa Altimari et al.
Elisa Gruppioni et al.
Molecular detection of monoclonality can play an important role in the diagnosis of posttransplantation lymphoproliferative disorders (PTLD). To permit accurate molecular diagnosis of PTLD even on very small amounts of DNA extracted from ro...
Differential diagnosis between complete and partial mole by TSSC3 antibody completely correlates to DNA diagnosis [0.03%]
TSSC3抗体用于完全性葡萄胎和部分性葡萄胎鉴别诊断的价值与DNA分析结果完全一致
Hidenori Kato,Takao Matsuda,Toshio Hirakawa et al.
Hidenori Kato et al.
Complete hydatidiform moles (CHMs) are a type of androgenetic fertilization without an ovum. Cases of CHM exhibit a generalized swelling of the villi and are known to be highly associated with persistent disease or carcinoma. In contrast, p...
A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis [0.03%]
SRY基因HMG框区新移码突变纯性腺发育不全患者一例
Richard Kellermayer,László Halvax,Márta Czakó et al.
Richard Kellermayer et al.
Pure gonadal dysgenesis or Swyer syndrome is a sex-reversal disorder resulting from embryonic testicular regression sequences especially during the first few weeks of fetal life and is induced by mutations in the SRY gene. In the present re...
Histologic, infectious, and molecular correlates of idiopathic spontaneous abortion and perinatal mortality [0.03%]
特发性流产和围产期死亡的组织学、感染和分子变化规律研究
Gerard J Nuovo,Lynn D Cooper,Deborah Bartholomew
Gerard J Nuovo
The purpose of this study was to analyze the placental and neonatal tissues in fatal cases for a wide variety of infectious agents and cytokine expression. Placentas and corresponding neonatal tissues in 21 consecutive cases of idiopathic s...
Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays [0.03%]
应用两种不同的PCR方法检测福尔马林固定的石蜡包埋组织中的猫抓病及其巴通体汉塞亚菌感染
Xiang Qian,Long Jin,Randall T Hayden et al.
Xiang Qian et al.
Cat scratch disease (CSD) is commonly caused by Bartonella henselae infection. Clinical history and histologic findings are often insufficient to establish a definitive diagnosis of CSD. We retrospectively studied formalin-fixed, paraffin-e...
Recurrent sarcoidosis in lung transplant allografts: granulomas are of recipient origin [0.03%]
原发性硬化性胆管炎患者的肝移植效果预测因素研究
Diana N Ionescu,Jennifer L Hunt,Daren Lomago et al.
Diana N Ionescu et al.
Introduction: Sarcoidosis accounts for only 2.8% of lung transplants in the United States. It is, however, the most commonly reported disease to recur after lung transplantation. In most cases, recurrence is diagnosed as ...