Mitochondrial DNA Stress Promotes the Ferroptosis of Endothelial Cells in Diabetic Peripheral Neuropathy by Upregulating ALOX15 [0.03%]
线粒体DNA压力通过上调ALOX15促进糖尿病外周神经病血管内皮细胞铁死亡
Xuan Zhang,Yu Yue,Ling Zhang et al.
Xuan Zhang et al.
Diabetic peripheral neuropathy (DPN) is a diabetic complication, featured by impaired vascular functions. This study investigates the roles of arachidonate 15-lipoxygenase (ALOX15) in DPN. High glucose (HG) is used to establish in vitro DPN...
FTO-Mediated RNA Hypomethylation of KCTD11 Promotes the Progression of Non-Small Cell Lung Cancer [0.03%]
FTO介导的KCTD11RNA低甲基化促进非小细胞肺癌的发展进展
Xin Liu,Bing Bai,Li Wei et al.
Xin Liu et al.
N6-methyladenosine (m6A) plays a role in tumorigenesis of lung cancer (NSCLC); FTO functions as an oncogene in various cancers. However, the molecular mechanism underlying FTO-promoted lung cancer progression is still unclear. Gene expressi...
Abigail Person,Andrew J Fritz,Emory Pacht et al.
Abigail Person et al.
Epigenetic control synergizes with DNA encoded regulatory information to provide a blueprint for gene expression that supports biological processes including phenotype, proliferation, growth control, metabolic regulation, cell survival, and...
Ming Zhang,Zhengbo Zhu,Qian Zhou et al.
Ming Zhang et al.
Myocardial fibrosis is a critical pathological process in the progression of heart failure and other cardiovascular diseases. Kaempferol (KMP), a natural flavonoid, has antioxidant and anti-inflammatory properties. This study investigates t...
Glycyrrhizin Alleviates Puromycin Aminonucleoside-Induced Podocyte Injury via Regulating Autophagy and GSDMD-Dependent Pyroptosis [0.03%]
甘草酸通过调节自噬和GSDMD依赖性焦亡缓解紫杉醇氨基核苷诱导的足细胞损伤
Wei Lu,Sheng-You Yu,Li-Na Wang et al.
Wei Lu et al.
Podocyte damage contributes to the progression of various renal diseases. This study aimed to investigate the effects of glycyrrhizin (GL) on podocyte injury. Puromycin aminonucleoside (PAN) was used to establish podocyte injury model in vi...
NAT10-Mediated N4-Acetylcytidine Modification of GRB7 Promotes the Progression of Gastric Cancer [0.03%]
NAT10介导的GRB7 N4-乙酰胞苷修饰促进胃癌进展
Min Huang,Zhengrong Zhang,Wenwu Yan et al.
Min Huang et al.
Gastric cancer (GC) is a highly prevalent malignancy with significant morbidity and mortality rates. N4-acetylcytidine (ac4C), an emerging RNA modification, has been implicated in tumorigenesis of GC. NAT10, an enzyme responsible for ac4C m...
Ziv Radisavljevic
Ziv Radisavljevic
Cancer cells are a complex and robust system dynamically interconnected by the signaling genes network through the up-regulated AKT gene. How signals are transmitted still is not clear. The hyperphosphorylated AKT locus during protein-prote...
Mechanism of Curcumin Inhibition of Malignant Progression of Lung Cancer Cells by Regulating Ferroptosis via the NRF2/HMOX1 Pathway [0.03%]
姜黄素通过NRF2/HMOX1途径调节铁死亡抑制肺癌细胞恶性进展的机制研究
Xiaoqi Guo,Tianci Han,Liang Zhang
Xiaoqi Guo
Inducing ferroptosis has become a means of hindering lung cancer progression. Curcumin regulates ferroptosis and participates in lung cancer progression, yet its mechanism on ferroptosis remains unclear. Semaphorin-6A attenuates lung cancer...
Michael May
Michael May
Cell division, the fundamental mechanism of reproduction, is the basis of life. In highly evolved organisms, particularly in humans exposed to abnormal chronical endogen and exogen stress-factors, uncontrolled cell division can occur. Consi...
METTL16-Mediated Upregulation of FGD5-AS1 Promotes Progression of Osteosarcoma through Targeting of miR-195-5p/SLC7A2 Axis [0.03%]
METTL16介导的FGD5-AS1上调通过靶向miR-155-5p / SLC7A2轴促进骨肉瘤进展
Weiqian Wu,Wenbiao Zheng,Weiwei Pan et al.
Weiqian Wu et al.
Dysregulated long noncoding RNAs (lncRNAs) promote the progression of osteosarcoma (OS). This study aimed to investigate the potential of lncRNA FGD5-AS1 in OS. Gene expression was determined using RT-qPCR. Protein expression was detected b...