Screening of miRNAs Characterizing Spinal Tuberculosis and Construction of Its Regulatory Network [0.03%]
脊柱结核的差异miRNA筛选及其调控网络构建
Wenxin Ma,Shichao Zhang,Lei Xu et al.
Wenxin Ma et al.
Background: Spinal tuberculosis (ST) poses a significant health risk as a severe infectious disease. MicroRNAs (miRNAs), key regulatory molecules, are implicated in the initiation and progression of ST. However, a compreh...
SPIB Modulates Macrophage Polarization and Correlates with Prognosis in Breast Cancer [0.03%]
SPIB调节巨噬细胞极化并与乳腺癌预后相关
Le Cui,Yun Li,Zhengjun Cui
Le Cui
Breast cancer (BC) is the leading malignancy affecting women globally, characterized by significant heterogeneity. Therefore, our objective was to explore potential targets within the context of intra-tumor heterogeneity (ITH) to modulate t...
Helicobacter pylori Suppress the Ferroptosis of Gastric Cancer via Inhibiting NAE1-Mediated Neddylation of TFR1 [0.03%]
幽门螺旋杆菌通过抑制NAE1介导的TFR1泛素样修饰抑制胃癌细胞铁死亡
Xinguo Wang,Xingting Ma,Lazati Baheti et al.
Xinguo Wang et al.
Helicobacter pylori (H. pylori) infection promotes the progression of gastric cancer. The purpose of this study is to investigate the effects of H. pylori infection on gastric cancer and the underlying mechanisms. mRNA levels were determine...
The circRHOBTB3/EIF4A3/NF-κB Axis Promotes Progression of Atopic Dermatitis [0.03%]
circRHOBTB3/EIF4A3/NF-κB轴促进特应性皮炎的进展
Haodong Chen,Jinqi Hao,Yang Zhang et al.
Haodong Chen et al.
Circular RNAs (circRNAs) are intensively involved in the progression of atopic dermatitis (AD). This study investigated the role of circRHOBTB3 in AD. Human keratinocytes (HaCaT) were treated with interleukin 4 (IL-4) to establish an in vit...
Identification of Novel Molecular Subtypes of Prostate Cancer Based on Genes Related to Metabolic Reprogramming to Assess Prognosis and Immune Landscape [0.03%]
基于与代谢重编程相关基因的新型前列腺癌分子亚型鉴定以评估预后和免疫图谱
Wentao Fan,Desheng Zhu,Jiawen Zheng et al.
Wentao Fan et al.
Prostate cancer (PRAD) progression varies significantly among patients, with metabolic reprogramming linked to oncogenesis and immune response. However, the prognostic and immune-related roles of metabolic reprogramming-related genes (MRGs)...
miR-143-3p Inhibits the Differentiation of Th1 Cells in Rhinosinusitis by Regulating TET1/IFN-γ Signaling [0.03%]
MiR-143-3p通过调控TET1/IFN-γ信号通路抑制鼻窦炎中Th1细胞的分化
Peiyuan Tang,Peng Zhang,Yiping Wang et al.
Peiyuan Tang et al.
Dysregulated microRNAs (miRNAs) are a hallmark of chronic rhinosinusitis, especially chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to investigate the role of miR-143-3p in chronic rhinosinusitis. miR-143-3p and mRNA le...
Possible Associations between PD1/PDL1 Gene Variants, Gene Expression, and Protein Expression and Clinical Outcome of Non-Small-Cell Lung Cancer [0.03%]
PD1/PDL1基因变异、表达与非小细胞肺癌临床疗效的关联分析
Şeyda Demirkol,Dilara Sönmez Zor,Merve S Uzunoğlu et al.
Şeyda Demirkol et al.
This study aimed to investigate the polymorphisms and protein expression of PD-1/PD-L1 molecules concerning non-small-cell lung cancer (NSCLC) susceptibility and their potential relationship with clinical parameters. PD-1 (rs2227981) and PD...
METTL3 Promotes Mitochondrial Dysfunction and Neuronal Ferroptosis in Cerebral Ischemia and Reperfusion Injury through YTHDC1/SLC7A11 Modification [0.03%]
METTL3通过YTHDC1/SLC7A11修饰促进脑缺血再灌注损伤中的线粒体功能障碍和神经元铁死亡
Boyu Chen,Ruoyu Deng,Yifei Chen et al.
Boyu Chen et al.
Methyltransferase 3 (METTL3) is dysregulated in various brain disorders. This study aimed to investigate the roles of METTL3 in cerebral ischemia and reperfusion (I/R) injury. Oxygen-glucose deprivation/reoxygenation (OGD/R) was used to est...
METTL14 Inhibits the Pyroptosis of Neurons in Parkinson's Disease via Upregulating NFE2 [0.03%]
METTL14通过上调NFE2抑制帕金森病神经元的焦亡
Xiaoli Hou,Ming Li,Huishen Yan et al.
Xiaoli Hou et al.
Methyltransferase-like 14 (METTL14) has been identified as a protective factor in central nervous system disorders, yet its involvement in Parkinson's disease (PD) remains underexplored. This study aimed to investigate the role of METTL14 i...
KDM5A-Mediated Methylation of GPR124 Contributes to PANoptosis of EA.hy926 Cells in Atherosclerosis [0.03%]
KDM5A介导的GPR124甲基化促进动脉粥样硬化中EA.hy926细胞PANoptosis发生
Yangyang Pang,Qingwen Meng,Qingyun Guo et al.
Yangyang Pang et al.
Lysine demethylase 5A (KDM5A) is involved in the progression of various heart diseases. This study aimed to investigate the role of KDM5A in atherosclerosis (AS). Oxidized low-density lipoprotein (OX-LDL) was used to establish AS model in v...