Human interleukin 1 [0.03%]
人白细胞介素1
T Krakauer
T Krakauer
Interleukin 1 (IL-1), a product of stimulated monocytes or macrophages, is defined by its ability to enhance the response of thymocyte to mitogenic stimulation. Numerous studies attribute a multiplicity of other biological functions to IL-1...
P del Guercio,D H Katz
P del Guercio
While both regulatory and effector functions within the T cell lineage have been extensively studied, B lymphocytes have been considered merely a source of humoral antibodies until recently. With the exception of antibody feedback, only a l...
A D Hess,P M Colombani,A H Esa
A D Hess
Cyclosporine (CsA) is a novel immunosuppressive agent currently used clinically, to prevent rejection of solid organ allografts and to prevent graft-vs.-host disease. Early studies in a variety of animal models exhibited transplantation tol...
R M Steinman,K Inaba
R M Steinman
This article will review the evidence that dendritic cells are specialized stimulator cells for the mixed leukocyte reaction. The topics to be considered are (1) identification of dendritic cells, (2) specialized stimulating capacity of den...
Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development [0.03%]
CD4糖蛋白决定基与人类免疫缺陷病毒包膜蛋白相互作用的特征研究及类毒素和疫苗开发展望
W L Farrar,A Harel-Bellan,D K Ferris
W L Farrar
The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 m...
Oncogenes and growth factors [0.03%]
癌基因与生长因子
J G Sinkovics
J G Sinkovics
Certain polypeptide gene products regulate mitosis, differentiation, and other basic biologic functions of cells. These genes and their products are well preserved throughout evolution. Other sets of genes encode receptors for these polypep...
Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus [0.03%]
提拉鼠脑脊髓炎：脱髓鞘及病毒持续感染模型
M Rodriguez,E Oleszak,J Leibowitz
M Rodriguez
Theiler's murine encephalomyelitis virus (TMEV) causes immune-mediated demyelination in susceptible mice which is similar to human demyelinating disorders such as multiple sclerosis. In addition, the picornavirus persists within the central...
T D Geppert,P E Lipsky
T D Geppert
The introduction of antigen into tissues can induce an inflammatory response initiated by antigen-specific T lymphocytes. Central to this process is the recognition of antigen by specific T cells that cannot respond to intact antigen direct...
Bidirectional interaction between the central nervous system and the immune system [0.03%]
中枢神经系统和免疫系统之间的双向交互作用
B S Rabin,S Cohen,R Ganguli et al.
B S Rabin et al.
We believe that any questions regarding whether the CNS can alter immune system functions no longer remain. It can conclusively be stated that the immune system is susceptible to influences of the CNS. It remains to be determined whether al...
P Christadoss
P Christadoss
Myasthenia gravis (MG) is an autoimmune neuromuscular disease manifested by muscle weakness and fatiguability. The primary pathology in MG is antibody and complement-mediated destruction of muscle acetylcholine receptor (AChR). Like other a...