Microvascular Endothelial Cell-Derived Exosomes Decrease Osteoclastogenesis by Restraining Osteoclast Ferroptosis through the USP13/NRF2/GPX4 Pathway [0.03%]
微血管内皮细胞来源的外泌体通过USP13/NRF2/GPX4通路限制破骨细胞铁死亡从而减少破骨细胞生成
Yajun Liu,Chen Xu,Zhaodong Wang et al.
Yajun Liu et al.
Exosomes (EXOs), released by diverse cells are implicated in modulating ferroptosis under orthopedic conditions. However, the possible effects of EXOs in osteoclasts and the interaction mechanisms with ferroptosis remain poorly defined. The...
Yu Lin,Hongfei Zhao,Dandan Meng et al.
Yu Lin et al.
Alzheimer's disease (AD) is a global neurodegenerative disorder characterized by progressive cognitive decline. Its core pathology involves neurofibrillary tangles mediated by hyperphosphorylated tau protein and senile plaques formed by ext...
STROBE-Cross-Population Mendelian Randomization Analysis of Circulating Inflammatory Proteins and Cervical Cancer Risk in European and Asian Populations [0.03%]
基于欧洲和亚洲人群的循环细胞因子蛋白与宫颈癌风险孟德尔随机化分析
Zhiying Xian,Xiangli Pang
Zhiying Xian
Objective: This study investigates the causal relationship between circulating inflammatory proteins and cervical cancer risk in European and Asian populations using Mendelian randomization (MR), providing insights into i...
Single-Cell RNA Analysis Reveals Aberrant Expression of Immune-Related Genes and Transcriptional Regulation of NK Cells in Chronic Obstructive Pulmonary Disease [0.03%]
单细胞RNA分析揭示慢性阻塞性肺疾病的免疫相关基因异常表达及NK细胞转录调控
Feng Cao,Weihang Hu,Yikuan Shen
Feng Cao
An increase in the number of natural killer (NK) cells in the lungs can be observed in chronic obstructive pulmonary disease (COPD). Immune-related genes (IRGs) play a crucial role in the differentiation of NK cells; however, the expression...
NLRC3 Inhibits the Migration and Invasion of Adenomyosis by Modulating the PI3K/AKT/mTOR Pathway in Endometrial Cells [0.03%]
NLRC3通过调节内膜细胞PI3K/AKT/mTOR信号通路抑制子宫腺肌病的侵袭和转移
Zhou Jiang,Yanping Liu,Boyu Yan et al.
Zhou Jiang et al.
Quantitative real-time PCR (qRT-PCR), western blotting, and immunohistochemical (IHC) staining were used to assess the expression of NLRC3 in tissues and cells. The effects of NLRC3 on the proliferation, apoptosis, migration, and invasion o...
Low-Toxicity Natural Killer Cell-Based Immunotherapy for NRAS-Driven Mucosal Melanoma: Advances in Immune Regenerative Medicine [0.03%]
低毒性的基于自然杀伤细胞的免疫疗法治疗NRAS驱动型黏膜黑色素瘤：免疫再生医学的新进展
Dipnarine Maharaj,Wen Zhang,Kawaljit Kaur et al.
Dipnarine Maharaj et al.
Anorectal mucosal melanoma (AMM) poses a significant challenge as a rare and aggressive cancer with limited treatment options. The current standard treatments for AMM have notable drawbacks, often leading to disease recurrence and progressi...
Galectin-10 Silencing Reduces Eosinophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps by Inhibiting the p38/MAPK/NF-κB Pathway [0.03%]
沉默半乳糖凝集素-10通过抑制p38/MAPK/NF-κB信号通路减轻鼻息肉型慢性鼻窦炎的嗜酸性粒细胞炎症反应
Chunhua Li,HongBing Liu
Chunhua Li
Galectin-10(Gal-10)/CLC(Charcot-Leyden crystal) has been discovered to be related to ECRSwNP characterized by high eosinophilic infiltration. We aimed to investigate the effects of Gal-10 on ECRSwNP. A total of 36 tissue samples were collec...
Caseinolytic Protease P: A Therapeutic Nexus in Infection, Inflammation, and Immunity [0.03%]
酪蛋白酶P：感染、炎症和免疫中的治疗交汇点
Shreya S Sonak,Sharda Ishwarkar,Charu Nimbarte et al.
Shreya S Sonak et al.
Caseinolytic protease P (ClpP) is a highly conserved serine protease that plays a pivotal role in protein homeostasis and quality control in bacteria, mitochondria of mammalian cells, and plant chloroplasts. As the proteolytic core of the A...
Role of Splenocytes on T Cells and Its Cytokine Network in Rheumatoid Arthritis [0.03%]
类风湿关节炎脾脏细胞及其细胞因子网络对T细胞的作用研究
Saayaa Nazar,Yeswanth Ranganathan,Helen Antony
Saayaa Nazar
Rheumatoid arthritis (RA) is a chronic autoimmune condition that impacts the immune system, especially through changes in the splenic immune cell system. This review provides an overview of the role of splenocytes in T cell signaling and th...
Modulation of T Cell Regulation by Interleukin-2 Agonists: Mechanisms and Clinical Implications [0.03%]
白细胞介素-2激动剂调节T细胞的作用机制及临床意义
Shreya S Sonak,Sharda Ishwarkar,Charu Nimbarte et al.
Shreya S Sonak et al.
IL-2 agonists significantly modulate T cell regulation, impacting activation, proliferation, differentiation, and immune homeostasis. Interleukin-2 (IL-2) is crucial for T cell growth and function, binding to the IL-2 receptor to trigger si...