Genetic basis of cell surface polymorphisms encoded by the major histocompatibility complex in humans [0.03%]
人类主要组织相容性复合体编码的细胞表面多态性的遗传基础
R J Duquesnoy,M Trucco
R J Duquesnoy
In this review, the authors have analyzed the relationship between molecularly defined HLA gene polymorphisms and the diversity of HLA antigens detected serologically and by T-cell allorecognition. Although many relevant publications were n...
K Ishizaka
K Ishizaka
Major research on the isotype-specific regulation of antibody responses was carried out in the IgE antibody response, and extended to the other isotypes. Because of dissociation between the IgE and IgG antibody responses, it was anticipated...
The use of antiidiotypic antibodies as vaccines against infectious agents [0.03%]
抗感染病原体的抗独特型抗体疫苗的研究进展与应用前景
R W Finberg,H Ertl
R W Finberg
The development of the antibodies to the combining site of an antigen-binding antibody has been documented in humans as well as experimental animals. These antibodies have been shown in experimental models to have an important regulatory ro...
P H Wooley,J M Chapedelaine
P H Wooley
CIA is a unique experimental model of disease, which may be particularly relevant to the study of RA, since it represents a true autoimmune reaction against a major joint component. Since it represents a model of the association of MHC gene...
K Eichmann,F Emmrich,S H Kaufmann
K Eichmann
We review the theoretical background as well as the available experimental data in animals and man on the possible use of anti-idiotypic antibodies as vaccines for the prevention of infectious diseases. In the first part, the basic experime...
M Zanetti
M Zanetti
The manuscript will deal with various aspects of the origin of autoantibody formation in relationship with idiotypy. The proposed analysis will cover three major aspects: (1) overview of the published data on idiotypic characterization of a...
F T Liu
F T Liu
The study of immunoglobulin genes has been an active area of research in recent years. The study of IgE heavy (epsilon) chain gene, in particular, has a significant impact on our understanding of the IgE system. The localization of the epsi...
J H Bertoglio
J H Bertoglio
This review addresses the questions of the molecular nature and of the physiological role of interleukin-1 (IL-1)-like activities produced by B lymphocytes. IL-1 was originally described as an exclusive product of activated monocytes/macrop...
Y Tochino
Y Tochino
Type 1 diabetes has been recognized as an organ-specific autoimmune disease. The NOD mouse showed a marked infiltration of T cells into the pancreatic islets and selectively destroyed B cells. The overt diabetes appeared in 90% of the femal...
A review of the structure and function of the T-cell receptor-T3 complex [0.03%]
T细胞受体-T3复合物的结构与功能综述
H C Oettgen,C Terhorst
H C Oettgen
Of fundamental importance in understanding the events involved in T cell activation is the identification and characterization of the relevant cell surface molecules. Antigen-induced stimulation and subsequent activation of the T cell are i...