Mechanism Study of Polydatin in Treating Spinal Cord Injury by Modulating Mitochondrial Membrane Potential Based on Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接的聚茋胺治疗脊髓损伤机制研究（线粒体膜电位调节角度）
Bo Dong,Xijing He
Bo Dong
Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural glycosylated precursor of resveratrol, showing mitochondr...
Novel PI(3)K-p85α/p110δ-ITK-LAT-PLC-γ2 and Fyn-ADAP-Carma1-TAK1 Pathways Define Reverse Signaling via FasL [0.03%]
新的PI(3)K-p85α/p110δ-ITK-LAT-PLC-γ2和Fyn-ADAP-Carm1-TAK1信号通路定义了经由FasL的反向信号
Pawan Kumar,Kamalakannan Rajasekaran,Subramaniam Malarkannan
Pawan Kumar
The role of FasL in initiating death signals through Fas is well characterized. However, the reverse signaling pathway downstream of FasL in effector lymphocytes is poorly understood. Here, we identify that FasL functions as an independent ...
Phage PEf771 for the Treatment of Periapical Periodontitis Induced by Enterococcus faecalis YN771 [0.03%]
用于治疗由肠球菌YN771诱导的根尖周牙周炎的噬菌体PEf771
Yingying Xiang,Rongyu Yang,Xuelin Li et al.
Yingying Xiang et al.
Enterococcus faecalis was the main causative bacteria of refractory periapical periodontitis (PP), there is a pressing need to explore effective methods for eradicating E. faecalis in patients with refractory PP. This study aimed to assess ...
Plausible Influence of HLA Class I and Class II Diversity on SARS-CoV-2 Vulnerability [0.03%]
HLA I类和II类多样性对新型冠状病毒易感性的影响研究
Neha Sharma,Gaurav Sharma,Devinder Toor
Neha Sharma
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the global coronavirus disease 2019 (COVID-19) pandemic, which adversely affected almost all aspects of human life and resulted in the loss of millions of lives, while affecting ne...
hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2 [0.03%]
circRNA hsa_circ_0037722通过与miR-140-3p和NR2F2互作驱动瘢痕疙瘩形成
Xixi Wu,Hu Gao,Fan Li
Xixi Wu
Keloids can invade normal skin tissues to lead to itching, pain, hemorrhaging and suppuration, thereby affecting the mental health of patients. circRNAs can participate in keloids formation, but the role of hsa_circ_0037722 in keloids is st...
The Potential Mechanisms of Qufeng Zhitong Capsule against Rheumatoid Arthritis Based on Network Pharmacology and In Vitro Experiments [0.03%]
基于网络药理学和体外实验的关节止痛膠囊治疗类风湿性关节炎的潜在机制研究
Haili Lin,Xiaokang Du,Yilu Wang et al.
Haili Lin et al.
Qufeng Zhitong capsule (QFZTC) is a traditional Chinese herbal formula with potential therapeutic efficacy in rheumatoid arthritis (RA). This study seeks to clarify the potential effects and mechanisms of QFZTC against RA. Active compounds ...
Prerona Boruah,Nikhita Deka
Prerona Boruah
IL-34, a cytokine, discovered a decade before and is known to be a colony stimulating factor CSF-1 receptor (CSF-1R) ligand. Along with CSF-1R, it also interacts with syndecan-1 receptors and protein-tyrosine phosphatase (PTP-ζ). Hence, IL...
Jin Zhao,Xiaofang Wang,Yusheng He et al.
Jin Zhao et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory decline and cognitive impairment, which is related to hallmark protein aggregates, amyloid-β (Аβ) plaques and neurofibrillary tangles; the latter...
ZC3H13 Enhances the Malignancy of Cervical Cancer by Regulating m6A Modification of CKAP2 [0.03%]
ZC3H13通过调节CKAP2的mRNA m6A修饰促进宫颈癌恶性进展
Yuan Zhang,Xiaoqing Chen,Huiqun Chen et al.
Yuan Zhang et al.
Sustained expression of zinc finger CCCH-type containing 13 (ZC3H13) in tumors is essential for cancer cell malignancy; however, our understanding of its clinical effects and mechanisms in cervical cancer (CC) is limited. In this study, we ...
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification [0.03%]
基于网络药理学、分子对接及实验验证的黄连素自噬相关抗非小细胞肺癌靶点筛选及其与免疫浸润的相关性研究
Liang Xu
Liang Xu
Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and identify novel therapeutic targets. ...