Overexpression of Homeobox A1 Relieves Ovalbumin-Induced Asthma in Mice and Is Associated with Blocking of the NF-κB Signaling Pathway [0.03%]
家盒A1的过表达缓解了卵清蛋白诱导的小鼠哮喘并且与阻断NF-κB信号通路有关
Jianye Yang,Wenbin Hu,Jiaming Zhao
Jianye Yang
Homeobox A1 (HOXA1) is a protein coding gene involved in regulating immunity signaling. This study aims to explore the function and mechanism of HOXA1 in asthma. An asthma mouse model was established via ovalbumin (OVA) induction. Airway hy...
A Machine Learning Method for a Blood Diagnostic Model of Pancreatic Cancer Based on microRNA Signatures [0.03%]
基于microRNA标记的胰腺癌血液诊断模型的机器学习方法
Bin Huang,Chang Xin,Huanjun Yan et al.
Bin Huang et al.
This study aimed to construct a blood diagnostic model for pancreatic cancer (PC) using miRNA signatures by a combination of machine learning and biological experimental verification. Gene expression profiles of patients with PC and transcr...
Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells [0.03%]
SOX18在脂多糖诱导的人脐静脉内皮细胞损伤中的分子机制
Jian Luo,Honglong Fang,Danqiong Wang et al.
Jian Luo et al.
Endothelial dysfunction is associated with the progression of sepsis. This study sought to probe the molecular route of sex-determining region on the Y chromosome-box transcription factor 18 (SOX18) in sepsis-associated endothelial injury. ...
Rhizoma Dioscoreae Nipponicae Relieves Asthma by Inducing the Ferroptosis of Eosinophils and Inhibiting the p38 MAPK Signaling Pathway [0.03%]
山薯能够通过诱导嗜酸性粒细胞发生铁死亡和抑制p38MAPK信号通路来缓解哮喘症状
Libin Jiang,Liying Xu,Huazuo Liu et al.
Libin Jiang et al.
Rhizoma Dioscoreae Nipponicae (RDN) is a traditional Chinese medicine that widely applied in the treatment of human diseases. This study aims to explore the therapeutic potential of RDN in asthma and the underlying mechanisms. A mouse model...
Similarities and Differences between Osteoclast-Mediated Functional Activation of NK, CD3+ T, and γδ T Cells from Humans, Humanized-BLT Mice, and WT Mice [0.03%]
破骨细胞介导的人类，人源化BLT小鼠和WT小鼠的NK细胞，CD3+T细胞及γδT细胞的功能活化的异同点
Kawaljit Kaur,Anahid Jewett
Kawaljit Kaur
This study is focused on assessing the activation in NK, CD3+ T, and γδ T cells when they interact with osteoclasts (OCs) and monocytes in the presence or absence of zoledronate (ZOL), both in humans and WT mice. OCs resulted in increased...
LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification [0.03%]
LAMA3通过METTL3介导的N6-甲基腺苷修饰促进口腔鳞状细胞癌的发生发展
Baoshan Ning,Yine Mei
Baoshan Ning
Laminin subunit alpha 3 (LAMA3) is a cancer regulator. However, its effects and regulatory pathways in oral squamous cell carcinoma (OSCC) progression remain unknown. This research aimed to determine the influence of LAMA3 regulation via me...
MicroRNA-99b Regulates Bacillus Calmette-Guerin-Infected Immature Dendritic Cell-Induced CD4+ T Cell Differentiation by Targeting mTOR Signaling [0.03%]
MicroRNA-99b通过调节mTOR信号通路调控卡介苗感染的未成熟树突状细胞诱导的CD4+T细胞的分化
Libo Zhen,Yuanyuan Chen,Juwei Gao et al.
Libo Zhen et al.
This study aimed to elucidate the mechanisms by which microRNA-99b (miR-99b) regulates CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature dendritic cells (imDCs). Levels of miR-99b, interferon-gamma (IFN...
Silencing of FUN14 Domain Containing 1 Inhibits Platelet Activation in Diabetes Mellitus through Blocking Mitophagy [0.03%]
FUN14结构域含1蛋白的沉默通过抑制线粒体自噬来阻断糖尿病血小板激活
Qiang Wu,Siwen Yu,Kangkang Peng
Qiang Wu
Platelet hyperactivity represents a deleterious physiological phenomenon in diabetes mellitus (DM). This study aimed to explore the role of FUN14 domain containing 1 (FUNDC1) in platelet activation within the context of DM and to uncover re...
TLR9 Knockdown Alleviates Sepsis via Disruption of MyD88/NF-κB Pathway Activation [0.03%]
TLR9敲减通过破坏MyD88/NF-κB通路激活缓解脓毒症
Lili Li,Lili Jiang,Shuzhu Mao et al.
Lili Li et al.
Sepsis is a life-threatening organ dysfunction due to dysregulated host response to infection, accompanied by a high rate of mortality worldwide. During sepsis progression, toll-like receptors (TLRs) play essential roles in the aberrant inf...
Integrated Bioinformatics Analysis to Identify a Novel Four-Gene Prognostic Model of Breast Cancer and Reveal Its Association with Immune Infiltration [0.03%]
综合生物信息学分析以识别新的四基因乳腺癌预后模型及其与免疫浸润的关系
Yunhua Zhu,Junjie Luo,Yifei Yang
Yunhua Zhu
Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we...