Exploring the Mechanism of Isoforskolin against Asthma Based on Network Pharmacology and Experimental Verification [0.03%]
基于网络药理学和实验验证探究Isoforskolin抗哮喘的作用机制
Yan Fang,Shibo Sun,Chuang Xiao et al.
Yan Fang et al.
In this study, network pharmacology combined with biological experimental verification was utilized to screen the targets of isoforskolin (ISOF) and investigate the potential underlying mechanism of ISOF against asthma. Asthma-related targe...
Identification of a Novel Five-Gene Prognostic Model for Laryngeal Cancer Associated with Mitophagy Using Integrated Bioinformatics Analysis and Experimental Verification [0.03%]
基于整合生物信息学分析和实验验证的五基因线粒体自噬相关喉癌预后模型的鉴定
Dong Song,Lun Dong,Mei Wang et al.
Dong Song et al.
Laryngeal cancer (LC) is a prevailing tumor with a high mortality rate. The pivotal role of mitophagy in LC is acknowledged; however, a comprehensive analysis of the corresponding genes has not been conducted. In the present study, we propo...
Different Doses of Dexmedetomidine Reduce Postoperative Sleep Disturbance Incidence in Patients under General Anesthesia by Elevating Serum Neurotransmitter Levels [0.03%]
不同剂量的右美托咪啶通过提高血清神经递质水平减少全麻患者的术后睡眠障碍发生率
Huifei Lu,Fei He,Ying Huang et al.
Huifei Lu et al.
Postoperative sleep disturbance is a common issue that affects recovery in patients undergoing general anesthesia. Dexmedetomidine (Dex) has a potential role in improving postoperative sleep quality. We evaluated the effects of different do...
KIAA1429 Induces m6A Modification of LINC01106 to Enhance the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway [0.03%]
KIAA1429通过JAK/STAT3途径诱导LINC01106的m6A修饰以增强肺腺癌细胞恶性度
Di Xu,Ziming Wang,Fajiu Li
Di Xu
Background: Sustained expression of the long noncoding RNA (lncRNA) LINC01106 in tumors is crucial for the malignant phenotype of tumor cells. Nevertheless, the mechanisms and clinical effects of LINC01106 in lung adenoca...
Effect of the p-Estrogen Receptor at Serine on Its Function and Breast Growth [0.03%]
p-雌激素受体丝氨酸位点的磷酸化对其功能和乳腺发育的影响
Yuan Liang,Junhui Qin,Tiancheng Ma et al.
Yuan Liang et al.
Background: Estrogen receptor (ER) signaling plays an important role in the development and functional differentiation of the breast and participates in the process of breast cancer. Activated ER can affect various aspect...
Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism [0.03%]
丹参素IIA改善术后低甲状旁腺功能的机制研究
Xiaoyu Qian,Lin Li,Liang Chen et al.
Xiaoyu Qian et al.
Background: Thyroidectomy causes impaired blood supply to the parathyroid glands, which leads to hypoparathyroidism. Tanshinone IIA (Tan IIA) is helpful in blood activation and cardiovascular protection. Therefore, the ef...
MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia [0.03%]
miRNA let-7d-5p通过靶向Map3k1并使ERK/p38MAPK信号失活来减轻小胶质细胞中的炎症反应
Fan Fang,Cheng Chen
Fan Fang
Alzheimer's disease (AD) is the most common form of dementia. Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of AD. In a large case-control study recruiting 208 patients with AD and 205 elderly control sub...
The Value of Systemic Immune-Inflammation Index and T Cell Subsets in the Severity and Prognosis of Sepsis [0.03%]
系统性免疫炎症指数和T细胞亚群在脓毒症严重程度及预后中的价值分析
Hao Zhou
Hao Zhou
Systemic immune-inflammation index (SII) and T cell subsets show involvement in mortality risk in septic patients, and we explored their predictive value in sepsis. Subjects were categorized into the Sepsis (SP)/Septic Shock (SSP)/Septic Sh...
Serum Interleukin-6 and Serum Ferritin Levels Are the Independent Risk Factors for Pneumonia in Elderly Patients [0.03%]
老年患者肺炎的独立危险因素是血清IL-6和血清铁蛋白水平
Hao Yuan,Jing Tian,Lu Wen
Hao Yuan
Pneumonia is a common infection in elderly patients. We explored the correlations of serum interleukin-6 (IL-6) and serum ferritin (SF) levels with immune function/disease severity in elderly pneumonia patients. Subjects were allocated into...
Clinical Significance of Serum CTRP3 Level in the Prediction of Cardiac and Intestinal Mucosal Barrier Dysfunction in Patients with Severe Acute Pancreatitis [0.03%]
CTRP3水平对重症急性胰腺炎患者心肌和肠黏膜屏障损伤的预测价值及临床意义
Qiang Shao,Lin Sun
Qiang Shao
C1q/tumor necrosis factor-related protein 3 (CTRP3) has been demonstrated to play a protective role in mice with severe acute pancreatitis (SAP). However, its clinical significance in SAP remains unknown. This study was conducted to explore...