Anahid Jewett,Sanaz Memarzadeh,Kawaljit Kaur
Anahid Jewett
Despite advancements in cancer therapeutics such as checkpoint inhibitors and some targeted therapies, we have not achieved success in effectively treating ovarian cancer, since these therapeutics only benefit a subset of patients, and also...
N6-Methyladenosine (m6A) Reader LRPPRC-Mediated CXCL11 Induces Cell Inflammation to Drive Breast Cancer Cell Malignancy [0.03%]
N6-甲基腺苷（m6A）阅读蛋白LRPPRC介导CXCL11诱导细胞炎症促进乳腺癌恶性进展
Qing Li,Changchun Zhang,Li Li
Qing Li
Breast cancer (BC) is among the most prevalent malignant cancers in women. We examined the function and regulatory mechanism of the N6-methyladenosine (m6A) modification reader leucine-rich pentatricopeptide repeat containing (LRPPRC) in BC...
Advances in Vaccines, Checkpoint Blockade, and Chimeric Antigen Receptor-Based Cancer Immunotherapeutics [0.03%]
癌症疫苗、免疫检查点阻断和嵌合抗原受体的癌症免疫治疗新进展
Disha Agarwal,Gaurav Sharma,Alka Khadwal et al.
Disha Agarwal et al.
Increase in cancer cases and research driven by understanding its causes, facilitated development of novel targeted immunotherapeutic strategies to overcome nonspecific cytotoxicity associated with conventional chemotherapy and radiotherapy...
The IRE1-XBP1 Axis Regulates NLRP3 Inflammasome-Mediated Microglia Activation in Hypoxic Ischemic Encephalopathy [0.03%]
IRE1-XBP1信号轴通过调控缺氧缺血性脑病中微胶质细胞活化介导的NLRP3炎性小体形成而参与调节神经炎症反应
Qun Cai,Liyuan Shen,Xiaoqun Zhang et al.
Qun Cai et al.
Hypoxic-ischemic encephalopathy (HIE) is a perinatal injury caused by cerebral hypoxia and reduced blood perfusion. Microglia activation-induced neuroinflammatory injury is a leading cause of neuron loss and brain injury. Efficient treatmen...
The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Recent Developments, and the Future of Therapeutic Interventions [0.03%]
SLE难题：病理机制、近期进展和未来治疗干预的全面分析
Uddeshya Sharma
Uddeshya Sharma
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with multifactorial interactions among various susceptibility factors. Significant strides have been made in understanding the pathogenesis of SLE, leading to the developme...
Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity [0.03%]
维生素D补充可降低儿童肥胖患者的高脂血症并改善骨密度
Feifan Wang,Lingshan Bei,Xiaoyan Zhang et al.
Feifan Wang et al.
The objective of this study was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for obesity and diabetes. Our aim was to dete...
Identification of Key Chondrocyte Apoptosis-Related Genes in Osteoarthritis Based on Weighted Gene Co-Expression Network Analysis and Experimental Verification [0.03%]
基于加权基因共表达网络分析和实验验证的骨关节炎软骨细胞凋亡相关关键基因鉴定
Wei Wang,Junyi Hong,Tianyi Cao et al.
Wei Wang et al.
Osteoarthritis (OA) is the primary cause of disability worldwide. Chondrocyte apoptosis has important implications for OA onset and progression. This work was designed to explore the mechanisms of chondrocyte apoptosis in OA and identify ke...
Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer [0.03%]
用于预测结肠癌患者生存和肿瘤细胞进展的 anoikis 和线粒体自噬相关基因标志物
Jian Shen,Minzhe Li
Jian Shen
Anoikis is a specialized form of programmed cell death and is also related mitophagy process. We aimed to identify an anoikis and mitophagy-related genes (AMRGs) prognostic model and explore the role of SPHK1 in colon cancer (CC). Bioinform...
Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy [0.03%]
类固醇受体共激活因子在T细胞和肿瘤中的功能及其对癌症免疫治疗的意义
Wencan Zhang,Xu Cao,Hongmin Wu et al.
Wencan Zhang et al.
Steroid receptor coactivator (SRC) family members (SRC1, SRC2 and SRC3) are transcriptional co-regulators. SRCs orchestrate gene transcription by inducing transactivation of nuclear receptors and other transcription factors. Overexpression ...
Electroacupuncture Suppresses Oxidative Stress and Ferroptosis by Activating the mTOR/SREBP1 Pathway in Ischemic Stroke [0.03%]
电针通过激活mTOR/SREBP1通路抑制缺血性脑卒中的氧化应激和铁死亡
Jiawang Lang,Jianchang Luo,Luodan Wang et al.
Jiawang Lang et al.
Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Electroacupuncture (EA) has been shown to exert a neuroprotective effect in IS. However, its specific anti-IS mechanisms remain to be fully elucidated. By ...