The Role of Checkpoint Inhibitors in Autoimmune Diseases: Similarities and Differences Compared with Cancer [0.03%]
检查点抑制剂在自身免疫性疾病中的作用：与肿瘤的异同点分析
Kawaljit Kaur,Po-Chun Chen,Meng-Wei Ko et al.
Kawaljit Kaur et al.
Programmed cell death-1 (PD-1) immunoinhibitory receptor expression is found on T cells, B cells, natural killer (NK) cells, and myeloid cells. Upon activation of T cells through peptide-major histocompatibility complex (MHC) engagement of ...
Davide Fattore,Luca Potestio,Lucia Genco et al.
Davide Fattore et al.
Immune system escape is one of the major strategies required for cancer growths. In this scenario, the advent of immune checkpoint inhibitors (ICIs) revolutionized the landscape of treatment options for tumors. Despite their wide use, these...
The Novel Diagnostic Index Based on HLA-DRB1 Genotype and PD-L1 Expression can Predict Severe irAEs in Patients with Metastatic Melanoma Taking Immune Checkpoint Inhibitors. The Results of the Pilot Study [0.03%]
基于HLA-DRB1基因型和PD-L1表达的新型诊断指数可以预测免疫检查点抑制剂治疗转移性黑色素瘤患者发生严重 irAEs。初步研究结果
N Zhukova,R Orlova,Anna Malkova et al.
N Zhukova et al.
Immune-related adverse events (irAEs) occur in up to 50% of patients treated with an anti-CTLA-4 antibody and 30% of patients treated with PD-1/PD-L1 antibodies. Severe forms of toxicity are observed in 3% of patients and require systemic s...
Vipin Kumar,Benjamin Bonavida
Vipin Kumar
Tregs and Platelets Play Synergistic Roles in Tumor Immune Escape and Inflammatory Diseases [0.03%]
调节性T细胞和血小板在肿瘤免疫逃逸和炎症性疾病中发挥协同作用
Huihui Gao,Ying Zhou,Xue Chen
Huihui Gao
Regulatory T cells (Tregs), a fraction of CD4+ T cells with immunosuppressive characteristics, are strongly linked to a number of inflammatory and autoimmune disorders. Furthermore, it also contributes to the development of tumors. Tregs in...
Microbiota-Specific Foxp3+ Regulatory T Cells Could Control Pathological T Helper Responses [0.03%]
微生物群特异性的Foxp3+调节性T细胞能够控制病理性的T辅助细胞反应
David Usharauli,Tirumalai Kamala
David Usharauli
Upon engaging cognate peptide MHC-II complexes (pMHC-IIs), naive CD4+ T cells differentiate and acquire several T helper (Th) fates, guided by a dynamic cytokine milieu following antigenic challenge. This physiological Th fate choice proces...
Sadashib Ghosh,Jianmei W Leavenworth
Sadashib Ghosh
Follicular regulatory T (TFR) cells are a population of CD4+ T-cells that concomitantly express markers for regulatory T-cells and follicular helper T (TFH) cells, and have been predominantly implicated in the regulation of humoral immunity...
Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells [0.03%]
人类天然调节性T细胞发育过程中IgG的免疫调控功能
Alessandra Franco
Alessandra Franco
The heavy constant region of IgG (Fc) is highly immunogenic for human natural regulatory T cells (nTreg). Mature IgG+ B cells prime Fc-specific Treg via recycling of surface immunoglobulin with an antigen-processing pathway that is very eff...
Ashley L Harkins,Acadia L Kopec,Allison M Keeler
Ashley L Harkins
A delicate balance of immune regulation exists in the central nervous system (CNS) that is often dysreg-ulated in neurological diseases, making them complicated to treat. With altered immune surveillance in the diseased or injured CNS, sign...
Xiaolei Tang,Vipin Kumar Chaturvedi
Xiaolei Tang
N/A.