Study of Therapeutic Mechanisms of Puerarin against Sepsis-Induced Myocardial Injury by Integrating Network Pharmacology, Bioinformatics Analysis, and Experimental Validation [0.03%]
网络药理学、生物信息学分析及实验验证结合研究染料木素抗内毒素性心肌损伤的作用机制
Yin Li,Lei Feng,Lin Bai et al.
Yin Li et al.
Myocardial injury is the most prevalent and serious complication of sepsis. The potential of puerarin (Pue) to treat sepsis-induced myocardial injury (SIMI) has been recently reported. Nevertheless, the specific anti-SIMI mechanisms of Pue ...
Muhammad Imran Qadir,Hina Bashir,Muhammad Hammad Ahmad
Muhammad Imran Qadir
Oral candidiasis is a common but most harmful oral cavity infection caused by yeast-like fungus, this condition is called Oropharyngeal candidiasis. There are various species of candida that are responsible for oral cavity fungal infection ...
Plausible Role of NLRP3 Inflammasome and Associated Cytokines in Pathogenesis of Rheumatic Heart Disease [0.03%]
NLRP3炎性小体及其相关细胞因子在风湿性心脏瓣膜病发病机制中的作用探讨
Aishwarya Rani,Devinder Toor
Aishwarya Rani
Rheumatic heart disease (RHD) is a post-streptococcal sequela caused by Streptococcus pyogenes. The global burden of disease is high among people with low socio-economic status, with significant cases emerging every year despite global erad...
The Potential Role of Cytotoxic Immune Effectors in Amyotrophic Lateral Sclerosis (ALS); A Longitudinal Case Study Comparing Patients with Genetically Identical Healthy Twin [0.03%]
细胞毒性免疫效应物在肌萎缩侧索硬化症（ALS)中的潜在作用；基因相同的健康双胞胎对照组病例纵向研究比较分析
Kawaljit Kaur,Po-Chun Chen,Meng-Wei Ko et al.
Kawaljit Kaur et al.
Amyotrophic lateral sclerosis (ALS) is an auto-immune neurodegenerative disorder affecting the motor-neurons. The causes of ALS are heterogeneous, and are only partially understood to date. We studied percentage and function of immune cell ...
Regulation of Cytotoxic Immune Effector Function by AJ3 Probiotic Bacteria in Amyotrophic Lateral Sclerosis (ALS) [0.03%]
AJ3益生菌通过调控细胞毒性免疫效应功能在渐冻症治疗中的应用研究
Po-Chun Chen,Kawaljit Kaur,Meng-Wei Ko et al.
Po-Chun Chen et al.
Our recent studies indicated that amyotrophic lateral sclerosis (ALS) patients suffer from significantly elevated levels of interferon-gamma (IFN-γ) secretion by natural killer (NK) and CD8+ T cells, which may be responsible for the immune...
Successes and Challenges in Taming the Beast: Cytotoxic Immune Effectors in Amyotrophic Lateral Sclerosis [0.03%]
攻克难题的成就与挑战：细胞毒性免疫效应细胞在肌萎缩侧索硬化症中的作用
Kawaljit Kaur,Po-Chun Chen,Meng-Wei Ko et al.
Kawaljit Kaur et al.
Amyotrophic lateral sclerosis (ALS) is a neurological disease characterized by the progressive loss of motor neurons in the brain and spinal cord. No effective therapeutic strategies have been established thus far, and therefore there is a ...
Natural Chalcones and Their Derivatives Target the Tumor Microenvironment in Colon Cancer [0.03%]
天然查耳酮及其衍生物靶向结直肠癌的肿瘤微环境
Rama Rao Malla,Satyalakshmi Siragam,Vasudha Dadi et al.
Rama Rao Malla et al.
Chalcones are the basic chemical structural predecessors of flavonoids and isoflavonoids, frequently available in many innately arising compounds. Chalcones and their counter parts have drawn the attention of many researchers because of the...
Mohan Krishna Ghanta,Poojith Nuthalapati,Neha Merchant et al.
Mohan Krishna Ghanta et al.
Parkinson's disease (PD) is a progressive condition that affects both the central nervous system and other body parts that are controlled by the nervous system. PD is characterized by brain dopaminergic neurons loss and, at present, there a...
γδ T Cell-Mediated Immune Responses for Cancer Therapy: Special Focus on Breast Cancer [0.03%]
针对癌症免疫治疗的γδ T细胞介导的免疫反应及其在乳腺癌中的应用
Rama Rao Malla,Priyamvada Bhamidipati
Rama Rao Malla
Triple-negative breast cancer (TNBC) is a type of breast cancer (BC) with high aggressive nature, devoid of receptors for estrogen and progesterone hormones and with overexpression of the HER2/neu protein. It is more aggressive than other t...
Artificial Intelligence and Precision Medicine: Outcome of Immunotherapy in Hepatocellular Carcinoma [0.03%]
人工智能与精准医疗：肝细胞癌免疫治疗的疗效预测模型
Esube Theodros,Ganji Purnachndra Nagaraju
Esube Theodros
The large amount of data collection coupled with the time-consuming nature of traditional methods of data analysis hinder the advancement of disease diagnosis and treatment. Precision medicine and personalized patient care approaches have p...