Comparison of Microbubbling and Conventional Bubbling Methods for Ozonated Saline Solution in CKD Patients: A Pilot Study [0.03%]
微气泡法和常规气泡法应用于CKD患者臭氧盐水中对比研究：一项初步研究
Estoneck Guevara-Aguilar,Diana Moroni-González,José Carlos Jiménez-Ortega et al.
Estoneck Guevara-Aguilar et al.
Chronic kidney disease (CKD) is a progressive condition marked by persistent kidney damage, leading to high mortality rates and economic burden in advanced stages. Ozone therapy has emerged as a complementary alternative capable of mitigati...
Exploring the Oxidative Mechanism of Methotrexate on Catalase Enzyme: An In Vitro Study [0.03%]
甲氨蝶呤对过氧化氢酶的氧化机制研究——体外实验探究
Fatemeh Jamali,Farzaneh Jafary,Mohammad Hossein Aarabi et al.
Fatemeh Jamali et al.
Methotrexate (MTX) is a well-known anti-metabolite agent recognized for its oxidative effects, particularly in the liver where the enzyme catalase is abundant. This research aimed to clarify the impact of MTX on the behavior of liver catala...
SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of Inflammatory Bowel Diseases [0.03%]
使用乳酸菌递送至肠道的SOD模拟物可以缓解炎症性肠病小鼠模型中的结肠炎症状
Gabrielle Schanne,Amandine Vincent,Florian Chain et al.
Gabrielle Schanne et al.
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis represent a global health issue as a prevalence of 1% is expected in the western world by the end of this decade. These idiseases are associated with a ...
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells [0.03%]
FABP3通过调节晶状体上皮细胞的铁死亡促进细胞凋亡和氧化应激
Qi Wang,Chunxiao Zhang,Bin Yu et al.
Qi Wang et al.
The purpose of this study is to investigate FABP3's biological function and potential mechanism in cataract. Treatment of H2O2 raised FABP3 expression. H2O2 decreased cell viability, enhanced apoptosis, promoted Bax and cleaved caspase-3 ex...
Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway [0.03%]
氢气通过ROS介导的线粒体内源性通路阻断细胞凋亡从而减轻心肌梗塞
Shuang Pan,Bin Wang,Mengshu Yu et al.
Shuang Pan et al.
Background: Acute myocardial infarction (AMI) is a deadly cardiovascular disease with no effective solution except for percutaneous coronary intervention and coronary artery bypass grafting. Inflammation and apoptosis of ...
Examining the Prognostic and Clinicopathological Significance of GPX4 in Human Cancers: A Meta-analysis [0.03%]
GPX4在人类癌症中的预后和临床病理意义的meta分析研究
Hao Wu,Xiting Liao,Wusixian Huang et al.
Hao Wu et al.
Elevated levels of the enzyme GPX4 have been detected in tumor tissues, which may play a role in cancer progression. We did a meta-analysis of eight studies encompassing 1180 individuals to evaluate the importance of GPX4 in cancer, particu...
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway [0.03%]
硒蛋白K的低表达通过抑制Nrf2抗氧化信号通路削弱鸡骨骼肌卫星细胞的增殖与分化能力
Xue-Wei Chen,Yue Li,Yi-Tong Fu et al.
Xue-Wei Chen et al.
Skeletal muscle satellite cells (SMSCs) are pivotal for skeletal muscle regeneration post-injury, and their development is intricately influenced by regulatory factors. Selenoprotein K (SELENOK), an endoplasmic reticulum (ER) resident selen...
Reactive oxygen species-mediated cytotoxic and DNA-damaging mechanism of N4-hydroxycytidine, a metabolite of the COVID-19 therapeutic drug molnupiravir [0.03%]
COVID-19治疗药物molnupiravir的代谢物N4-羟基胞嘧啶通过活性氧介导的细胞毒性和DNA损伤机制
Yurie Mori,Rinya Yogo,Hatasu Kobayashi et al.
Yurie Mori et al.
Molnupiravir is a prodrug of the antiviral ribonucleoside analogue N4-hydroxycytidine (NHC), for use in treatment of coronavirus disease 2019 (COVID-19). However, it is generally considered that NHC-triphosphate is incorporated into the hos...
Metformin ameliorates Gestational Diabetes Mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathway [0.03%]
二甲双胍通过Nrf2/HO-1信号通路抑制胎盘滋养层细胞铁死亡改善妊娠期糖尿病
Lingya Fang,Sha Lu,Liuyuan Fang et al.
Lingya Fang et al.
Both mothers and infants experience oxidative stress due to gestational diabetes mellitus (GDM), which is strongly associated with adverse pregnancy outcomes. Ferroptosis, a novel form of programmed cell death characterized by iron-dependen...
Gold Nanoparticles-Supported Iron Oxide Particles Endows Bone Scaffolds with Anti-tumor Function [0.03%]
负载金纳米粒子的铁氧化物颗粒使骨支架具备抗肿瘤功能
Tiantian He,Wenjing Yang,Youwen Yang et al.
Tiantian He et al.
Iron oxide (Fe-O) have anti-tumor properties, due to its ability of catalyzing hydrogen peroxide (H2O2) of tumor cells to the generate reactive oxygen species (ROS) and then causing ferroptosis. Its anti-tumor performance is restricted due ...