Mitochondrial antioxidant enzyme (SOD2) at the crossroads of redox signaling and cancer progression [0.03%]
位于红氧平衡信号和癌症发展交叉点的线粒体抗氧化酶（SOD2）
Md Rafikul Islam,Rashedul Alam,Farhadul Islam et al.
Md Rafikul Islam et al.
Normal cells preferably utilize mitochondrial oxidative phosphorylation as the primary source of energy in aerobic conditions. However, superoxide anions (.O2-) are produced as a by-product due to leakage of the electron from the electron t...
Carnosine Alleviates High Glucose-Induced Renal Tubular Cell Pyroptosis by Activating the AMPK/SIRT3/SOD2 Pathway [0.03%]
卡尼丁通过激活AMPK/SIRT3/SOD2信号通路缓解高糖诱导的肾小管上皮细胞焦亡
Kunxiao Zhao,Wenting Zhao,Xiuhong Hu et al.
Kunxiao Zhao et al.
Background: Diabetic nephropathy (DN) is a major complication driven by inflammation and oxidative stress; mtROS-activated NLRP3 inflammasome-induced pyroptosis is a key mechanism. Carnosine, notably an endogenous dipepti...
Spermidine improve high copper diet -induced intestinal oxidative stress and microbiota community composition [0.03%]
spermidine改善高铜饮食引起的肠道氧化应激及菌群结构失调
Yuxin Qi,Dongmei Jiang,Shuo Li et al.
Yuxin Qi et al.
Introduction: High copper diet intake detriment animal health and livestock profitability. As a key polyamine, spermidine modulates critical physiological processes, include regulating autophagy and oxidative stress. Howe...
Molecular mechanism of METTL7B-mediated m6A modification in ferroptosis of non-small cell lung cancer cells [0.03%]
METTL7B介导的非小细胞肺癌细胞铁死亡m6A修饰的分子机制研究
Rancen Tao,Zuo Liu,Zhenning Zhang et al.
Rancen Tao et al.
Non-small cell lung cancer (NSCLC) is the predominant form of lung cancer. Ferroptosis is a novel therapeutic target against treatment resistance in NSCLC. However, its regulation by m6A RNA modification remains incompletely elucidated. m6A...
Follicular Fluid Oxidative Stress and Antioxidant Defense in Relation to Maternal Age, Ovarian Reserve, and In Vitro Fertilization Outcomes [0.03%]
与母亲年龄、卵巢储备和体外受精结果相关的卵泡液氧化应激和抗氧化防御能力
Oya Korkmaz,Seda Karabulut,Pelin Macit et al.
Oya Korkmaz et al.
Oxidative stress within the follicular microenvironment plays a critical role in oocyte quality and reproductive outcomes. This prospective study examines the association between follicular fluid redox status, maternal age, ovarian reserve,...
Mechanistic and kinetic insights into the radical scavenging capacity and Keap1-Nrf2 inhibition potency of A-type avenanthramides: DFT and molecular docking [0.03%]
DFT和分子对接对A型燕麦蒽酰胺清除自由基及抑制Keap1-Nrf2活性的机制和动力学研究见解
Jiayi Li,Guirong Wang,Zhennan Zhang et al.
Jiayi Li et al.
Avenanthramides (AVAs), unique polyphenols in oats, have received much attention due to their biologically beneficial properties. Herein, density functional theory (DFT) calculations and molecular docking were performed to elucidate the str...
Role of Ferroptosis in 2, 4, 6-Trinitrobenzenesulfonic acid Induced Ulcerative Colitis: Targeting Iron Metabolism for Therapeutic Gain [0.03%]
铁死亡在2,4,6-三硝基苯磺酸诱导的溃疡性结肠炎中作用：靶向铁代谢以获得治疗益处
Akashata Devkar,Satish Mandlik,Deepa Mandlik
Akashata Devkar
Ulcerative colitis (UC), a major form of inflammatory bowel disease (IBD), is characterized by chronic inflammation and ulceration of the colonic mucosa. Its etiology is multifactorial, involving genetic, environmental, and immune factors. ...
Molecular Insights of p-Benzoquinone-Induced Red Blood Cell Dysfunction: Probable Implications to Cigarette Smoke-Associated Pathologies [0.03%]
对苯醌诱导的红细胞功能障碍的分子机制洞察及其可能与吸烟相关疾病的关系研究
Neha Yadav,Rishita Singh,Santosh Kumar Mondal et al.
Neha Yadav et al.
Cigarette smoke (CS) is a complex mixture of numerous chemicals, including p-benzosemiquinone (pBSQ), which oxidizes to p-benzoquinone (pBQ) in the lungs of smokers and enters circulation. Despite its high reactivity, the direct impact of p...
Spermidine diminishes lipopolysaccharide-induced myocardial ferroptosis through the Keap1-Nrf2/HO-1 pathway [0.03%]
spermidine通过Keap1-Nrf2/HO-1途径减少脂多糖诱导的心肌铁死亡
Jun He,Xiaohong Zhang,Hongxin Jiang et al.
Jun He et al.
Spermidine (SPD) is a naturally-occurring polyamine with a range of unique properties including anti-inflammatory, antioxidant, and cardioprotective effects. Ferroptosis, a form of cell death that is regulated by reactive oxygen species (RO...
Non-thermal plasma prevents IgE-mediated Ca2+ influx and allergic response in RBL-2H3 cells [0.03%]
非热等离子体可抑制IgE介导的RBL-2H3细胞内钙离子浓度升高及过敏反应
Tomohiro Otsuka,Ibuki Tomonaga,Koji Watabe et al.
Tomohiro Otsuka et al.
Non-thermal plasma (NTP) has been reported to exhibit various biological effects, including hemostatic, anticancer, and wound-healing properties. However, the effects of NTP on allergic responses in mast cells and basophils have not been su...