The impact of hyperbaric oxygen therapy on the redox balance of patients with diabetic foot syndrome [0.03%]
高压氧治疗对糖尿病足综合征患者氧化还原平衡的影响
Paweł Sutkowy,Jarosław Paprocki,Jacek Piechocki et al.
Paweł Sutkowy et al.
Diabetic foot wounds associated with oxidative stress are treated with hyperbaric oxygen (HBO), but that may also induce the stress itself; therefore, we studied the effect of HBO treatments on the oxidant-antioxidant balance in the venous ...
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress [0.03%]
二甲双胍通过激活氧化应激介导的铁死亡和凋亡抑制代谢紊乱相关性脂肪肝病
Zhiyu Li,Chao Cui,Liang Xu et al.
Zhiyu Li et al.
Metformin is known for its antioxidant properties and ability to ameliorate metabolic dysfunction-associated fatty liver disease (MAFLD) and is the focus of this study. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is linked to MAFLD ri...
Redox remodeling of central metabolism as a driving force for cellular protection, proliferation, differentiation, and dysfunction [0.03%]
中枢代谢的氧化还原重构是细胞保护、增殖、分化和功能障碍的主要驱动力
Junichi Fujii
Junichi Fujii
The production of reactive oxygen species (ROS) is elevated via metabolic hyperactivation in response to a variety of stimuli such as growth factors and inflammation. Tolerable amounts of ROS moderately inactivate enzymes via oxidative modi...
Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation [0.03%]
溶酶体条件下氧化的低密度脂蛋白降低动脉血管舒张功能
Hadeel K M Alboaklah,Alister J McNeish,David S Leake
Hadeel K M Alboaklah
Endothelial dysfunction is a risk factor for atherosclerosis and includes impaired endothelium-dependent vasodilatation. We have shown previously that low density lipoprotein (LDL) can be oxidized by iron in the lysosomes of macrophages. Ma...
The inhibitory potential of 4,7-dihydroxycoumarin derivatives on ROS-producing enzymes and direct HOO•/o2• - radical scavenging activity - a comprehensive kinetic DFT study [0.03%]
4,7-二羟基香豆素衍生物对产ROS酶的抑制作用和直接HOO• /O2•?-自由基清除活性——全面的动力学DFT研究
Žiko Milanović,Svetlana Jeremić,Marko Antonijević et al.
Žiko Milanović et al.
This study examined the antiradical activity of three synthesized coumarin derivatives: (E)-3-(1-((2-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl acetate (A1-OH), (E)-3-(1-((3-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl a...
EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells [0.03%]
EP4受体激动剂CAY10598通过上调ROS依赖性Hsp90裂解促进结直肠癌细胞的自噬死亡
In Gyung Chae,Joohee Jung,Do-Hee Kim et al.
In Gyung Chae et al.
Prostaglandin E2 (PGE2) interacts with four specific G protein-coupled receptors, namely EP1, EP2, EP3, and EP4, playing a pivotal role in determining the fate of cells. Our previous findings highlighted that stimulating the EP4 receptor wi...
Polyphenolic metacyclophane as a radical scavenger for therapeutic activation: a computational study [0.03%]
基于计算研究的自由基清除剂类meta-环己烷茋酚并四苯化合物用于激活药物方面的研究
Raktim Nath,Alaiha Zaheen,Sanchaita Rajkhowa et al.
Raktim Nath et al.
Modeling antioxidants for improved human health is a prime area of research. Inclusion complexes exhibit antioxidant activity. Supramolecular scaffolds like calixtyrosol are anticipated to have considerable antioxidant and therapeutic activ...
Reduction of oxidative damage in prostate tissue caused by radiation and/or chloroquine by apocynin [0.03%]
阿朴摩尔灵降低放射和（或）氯喹引起的小鼠前列腺组织氧化损伤
Onur Ertik,Ayca Sezen Us,Ilknur Bugan Gul et al.
Onur Ertik et al.
Prostate damage can occur in men due to age and genetic factors, especially when exposed to external factors. Radiation (RAD) is a prominent factor leading to oxidative stress and potential prostate damage. Additionally, chloroquine (CQ), u...
Hydroxyl radical scavenging and chemical repair capabilities of positively charged peptides (PCPs): a pulse radiolysis study [0.03%]
阳离子肽（PCP）的羟基自由基清除和化学修复能力的脉冲辐射解研究
Chaozhong Tian,Shinichi Yamashita,Atsushi Kimura et al.
Chaozhong Tian et al.
Pulse radiolysis was employed to investigate fundamental radiation chemical reactions, which are essential in the radiation protection of DNA. Two positively charged peptides (PCPs), histidine-tyrosine-histidine (His-Tyr-His) and lysine-tyr...
Antioxidant properties of α-amino acids: a density functional theory viewpoint [0.03%]
α-氨基酸的抗氧化性能研究——密度泛函理论视角
Andrey A Buglak
Andrey A Buglak
The antioxidant properties of 21 proteinogenic amino acids (AAs) and 3,4-dioxophenylanine (DOPA) have been studied in implicit water using density functional theory (DFT). All the calculations have been performed according to three oxidatio...