PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma [0.03%]
载有PTEN和TRAIL基因的玉米醇溶蛋白纳米颗粒作为肝细胞癌潜在疗法的研究
Fathia Zaki El Sharkawi,Shaimaa Mohammed Ewais,Rania Hassan Fahmy et al.
Fathia Zaki El Sharkawi et al.
Gene therapy is one of the recent approaches in treatment of hepatocellular carcinoma (HCC). Development of a vector or vehicle that can selectively and efficiently deliver the gene to target cells with minimal toxicity is an urgent demand....
Effects of cell penetrating Notch inhibitory peptide conjugated to elastin-like polypeptide on glioblastoma cells [0.03%]
穿膜Notch抑制肽与弹性蛋白多肽偶联对胶质瘤细胞的影响
Teuta Opačak-Bernardi,Jung Su Ryu,Drazen Raucher
Teuta Opačak-Bernardi
Notch pathway was found to be activated in most glioblastomas (GBMs), underlining the importance of Notch in formation and recurrence of GBM. In this study, a Notch inhibitory peptide, dominant negative MAML (dnMAML), was conjugated to elas...
Recent progress in drug delivery of pluronic P123: pharmaceutical perspectives [0.03%]
星型嵌段聚合物Pluronic P123在药物传输中的应用进展与制药学观点
Li-Yan Zhao,Wan-Ming Zhang
Li-Yan Zhao
This review focuses on recent investigations that used Pluronic P123 (P123) as pharmaceutical ingredients in vesicle, micelle, mixed micelle, in situ gel, tablet and emulsion. The main results from these studies show that P123 can significa...
Current treatment strategies and nanocarrier based approaches for the treatment and management of diabetic retinopathy [0.03%]
糖尿病视网膜病变治疗和管理的当前策略及纳米载体-based方法
Kousalya Selvaraj,Kuppusamy Gowthamarajan,Veera Venkata Satyanarayana Reddy Karri et al.
Kousalya Selvaraj et al.
Diabetic retinopathy (DR) is a leading cause of blindness in all working age groups which contribute to patient's quality of life. Considering the anatomy and physiology of barriers in the eye, the treatment and management of pathologic ocu...
Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery: preparation, characterization and in vitro evaluation [0.03%]
雾化阴离子型季铵化O-羧甲基壳聚糖/N-2-羟丙基三甲胺氯化物壳聚糖纳米颗粒递送siRNA的制备、表征及体外评价研究
Suhui Ni,Yuwen Xie,Yue Tang et al.
Suhui Ni et al.
This study developed a pH-sensitive anionic system composed of guanidinylated O-carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride chitosan (N-2-HACC) for efficient siRNA delivery to the lungs following nebulizat...
Preparation and in vitro/in vivo evaluation of metformin hydrochloride rectal dosage forms for treatment of patients with type II diabetes [0.03%]
盐酸二甲双胍直肠给药制剂的制备及其体内外评价研究
Abdel-Azim Zaghloul,Ahmad Lila,Fathy Abd-Allah et al.
Abdel-Azim Zaghloul et al.
Background: Metformin hydrochloride (MtHCL) is an oral antidiabetic drug and has many other therapeutic benefits. It has poor bioavailability, narrow absorption window and extensive liver metabolism. Moreover, children an...
Marie Iwanaga,Yukinobu Kodama,Takahiro Muro et al.
Marie Iwanaga et al.
The purpose of this study was to develop a ternary complex of plasmid DNA (pDNA) electrostatically assembled with dendrigraft poly-l-lysine (DGL) and biodegradable glycosaminoglycan for effective and secure gene delivery. High gene expressi...
An in vitro demonstration of overcoming drug resistance in SKOV3 TR and MCF7 ADR with targeted delivery of polymer pro-drug conjugates [0.03%]
聚合物前药缀合物靶向递送克服SKOV3 TR和MCF7 ADR耐药性的体外研究
Prashant Bhattarai,Dylan Vance,Arash Hatefi et al.
Prashant Bhattarai et al.
Drug resistance is a common phenomenon that occurs in cancer chemotherapy. Delivery of chemotherapeutic agents as polymer pro-drug conjugates (PPDCs) pretargeted with bispecific antibodies could circumvent drug resistance in cancer cells. T...
Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue [0.03%]
用于大鼠皮肤组织局部递送辣椒素的溶解型微针
Yukako Ito,Shinji Kobuchi,Genta Inoue et al.
Yukako Ito et al.
Capsaicin-loaded dissolving microneedles (DMNs) were prepared to investigate the analgesic effect of capsaicin on the skin. The dimensions of each microneedle (MN) were as follows: diameter of the basement, 17 mm; length, 500 μm; and width...
Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy [0.03%]
叶酸修饰和功能化的CuS纳米晶基纳米颗粒的合成及其在肿瘤化疗与光热治疗中的应用研究
Xiali Zhu,Yingjie Zhang,Heqing Huang et al.
Xiali Zhu et al.
Recent studies have identified that CuS nanocrystal (CuS NCs) could be used as a new class of promising photo-thermal agents due to their excellent plasmonic absorption abilities in a wide near-infrared (NIR) region. However, most of nanoca...