Novel, nano-sized, liposome-encapsulated polyamidoamine dendrimer derivatives facilitate tumour targeting by overcoming the polyethylene glycol dilemma and integrin saturation obstacle [0.03%]
新颖的纳纳米粒化脂质体包封聚胺芳香族树状聚合物衍生物通过克服PEG两难和整联蛋白饱和障碍来实现肿瘤靶向递送
Gang Li,Yan-Zhi Song,Zhen-Jun Huang et al.
Gang Li et al.
Drug delivery systems (DDSs) commonly employ arginine-glycine-aspartic acid (RGD) peptides with polyethylene glycol (PEG)-dependent enhanced permeability and retention (EPR) effect to optimise tumour-targeting. However, the PEG dilemma and ...
Specific hepatic stellate cell-penetrating peptide targeted delivery of a KLA peptide reduces collagen accumulation by inducing apoptosis [0.03%]
一种特定的肝星状细胞穿膜肽递送KLA肽可诱导肝星状细胞凋亡并减少细胞外基质累积
Zhengrong Guo,Dong Li,Huanyan Peng et al.
Zhengrong Guo et al.
Liver fibrosis is an aberrant wound-healing process to chronic hepatic inflammation and is characterized by excessive accumulation of extracellular matrix (ECM) that is produced by activated hepatic stellate cells (HSCs). Thus, activated HS...
Intracellular localisation of proteins to specific cellular areas by nanocapsule mediated delivery [0.03%]
纳米胶囊介导的蛋白质输运及其在细胞内特定区域的位置定位
Huabin Wang,Ligang Chen,Xianchao Sun et al.
Huabin Wang et al.
Nanocapsules are promising carriers with great potential for intracellular protein transport. Although many studies have intended to improve cell uptake efficacy, there is an increasing interest in understanding of subcellular distribution ...
Design of multifunctional liposome-quantum dot hybrid nanocarriers and their biomedical application [0.03%]
多功能脂质体量子点杂化纳米载体的设计及生物医学应用研究
Wenjing Qu,Wenbao Zuo,Na Li et al.
Wenjing Qu et al.
Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have rich surface chemistry and unique optical properties that make them useful as probes or carriers for molecular diagnostics and therapeutics. However, their poten...
MiR-33b-5p sensitizes gastric cancer cells to chemotherapy drugs via inhibiting HMGA2 expression [0.03%]
miR-33b-5p通过抑制HMGA2表达增强胃癌细胞对化疗药物的敏感性
Xiaoyan Yang,Qian Zhao,Huali Yin et al.
Xiaoyan Yang et al.
MicroRNAs (miRNAs) are internal, non-coding, and ∼22 nt small RNAs that display cell- and tissue-specific expression. They play important regulatory roles in cell proliferation and chemo-sensitivity. This study focused on tumor-suppressive...
Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition [0.03%]
姜黄素通过表观遗传激活miR-143和miR-143介导的自噬抑制增敏前列腺癌细胞放射效应
Jianbo Liu,Min Li,Yuewei Wang et al.
Jianbo Liu et al.
Curcumin has been reported as a radiosensitizer in prostate cancer. But the underlying mechanism is not well understood. In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster. Then, we investigate...
One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin [0.03%]
用于协同递送阿霉素和姜黄素的脂质-聚丙烯酸-碳酸钙纳米粒的一锅法合成
Jianqing Peng,Shintaro Fumoto,Hirotaka Miyamoto et al.
Jianqing Peng et al.
A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of t...
Yujie Ji,Hongzhi Qiao,Jiayu He et al.
Yujie Ji et al.
Oligopeptides, a type of short peptide, which consist of 2-20 amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the e...
Correction to: Huey, Rachel, Hawthorne, Susan, The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review [0.03%]
兔病毒糖蛋白派生肽在中枢神经系统药物递送中的潜在应用：迷你综述的更正公告
Published Erratum
Journal of drug targeting. 2017 Jun;25(5):i. DOI:10.1080/1061186X.2017.1302138 2017
LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells [0.03%]
长链非编码RNA PVT1通过表观遗传学方式抑制miR-195并调节宫颈癌细胞的上皮间质转化和化疗耐药性
Ching-Ju Shen,Ya-Min Cheng,Chiu-Lin Wang
Ching-Ju Shen
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and...