A novel synergetic targeting strategy for glioma therapy employing borneol combination with angiopep-2-modified, DOX-loaded PAMAM dendrimer [0.03%]
采用脑渗透肽-2修饰、载多西环素的聚酰胺-胺树状大分子配合龙脑协同靶向治疗胶质瘤的新策略研究
Shunping Han,Hongyue Zheng,Yanping Lu et al.
Shunping Han et al.
Glioma is the most common primary malignant brain tumour and the effect of chemotherapy is hampered by low permeability across the blood-brain-barrier (BBB). Borneol is a time-honoured 'Guide' drug in traditional Chinese medicine and has be...
The targeting effect of Hm2E8b-NCTD-liposomes on B-lineage leukaemia stem cells is associated with the HLF-SLUG axis [0.03%]
Hm2E8b-NCTD-脂质体对B系白血病干细胞的靶向效应与HLF-SLUG轴相关
Jingying Zhang,Diying Shen,Min Jia et al.
Jingying Zhang et al.
To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-...
Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer [0.03%]
用于克服耐多药乳腺癌的还原触发式米托蒽醌前药型胶束
Hongzhi Qiao,Zhenzhu Zhu,Dong Fang et al.
Hongzhi Qiao et al.
Multidrug resistance (MDR) severely hinders the efficient chemotherapeutic treatments of cancer. d-α-Tocopherol polyethylene 1000 succinate (TPGS) based drug delivery system holds the potential of re-sensitizing resistant cancer cells. In ...
Therapeutic efficacy of folate receptor-targeted amphiphilic cyclodextrin nanoparticles as a novel vehicle for paclitaxel delivery in breast cancer [0.03%]
靶向叶酸受体的两亲性环糊精纳米颗粒作为递送紫杉醇治疗乳腺癌的新载体的疗效研究
Nazlı Erdoğar,Güneş Esendağlı,Thorbjorn T Nielsen et al.
Nazlı Erdoğar et al.
Purpose: The aim of this study is to test folate-conjugated cyclodextrin nanoparticles (FCD-1 and FCD-2) as a vehicle for reducing toxicity and increasing the antitumor efficacy of paclitaxel especially for metastatic bre...
Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease [0.03%]
针对线粒体靶向型抗氧化剂在炎症性肠病治疗中的应用及其意义
Abel Matondo,Sung Soo Kim
Abel Matondo
The role of the mitochondria, particularly its implications in cellular redox and oxidative balance is important for cell survival, and is involved in a variety of human diseases including inflammatory bowel disease (IBD). In this review we...
Contribution of nucleophosmin overexpression to multidrug resistance in breast carcinoma [0.03%]
核蛋白磷酸酶过表达与乳腺癌多药耐药的关系
Siying Chen,Ti Meng,Xiaowei Zheng et al.
Siying Chen et al.
Multidrug resistance (MDR) is a serious obstacle in breast cancer patients which limits chemotherapeutic drugs application. Our previous study confirmed that overexpression of nucleophosmin (NPM) was closely related to MDR in methotrexate-r...
Characterization of an encapsulated insulin secreting human pancreatic beta cell line in a modular microfluidic device [0.03%]
一种包封的分泌胰岛素的人类胰腺β细胞系在模块化微流控设备中的表征研究
Argia Acarregui,Jesús Ciriza,Laura Saenz Del Burgo et al.
Argia Acarregui et al.
Type I diabetes mellitus is characterised by the destruction of the insulin producing beta cells within the pancreas by the immune system. After the success of Edmonton protocol, islet transplantation has shown to be a promising therapy, bu...
Potential of novel drug delivery systems in the management of topical candidiasis [0.03%]
新型给药系统在 topical 白色念珠菌感染管理中的潜力
Mahima Mathur,V Kusum Devi
Mahima Mathur
High prevalence of topical fungal infections is perceived in majority of nations worldwide accounting for numerous serious systemic complications. Of several fungal infections, candidiasis is one of the widespread infections which is manife...
Preparation of chondroitin sulfate-adipic acid dihydrazide-doxorubicin conjugate and its antitumour characteristics against LLC cells [0.03%]
硫酸软骨素-己二酰二肼-多柔比星偶联物的合成及体外抗瘤活性研究
Hiraku Onishi,Ai Fukasawa,Andang Miatmoko et al.
Hiraku Onishi et al.
Macromolecule-antitumour drug conjugates can reach tumour sites specifically via the enhanced permeability and retention (EPR) effect. It is desirable to release the drug efficiently from the conjugate at acidic pH in the tumour tissue or i...
The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery [0.03%]
基于多糖的纳米凝胶在肽/蛋白质和抗肿瘤药物递送中的应用
Lin Zhang,Jifei Pan,Shibo Dong et al.
Lin Zhang et al.
Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels ...