Brucea javanica oil emulsion alleviates cachexia induced by Lewis lung cancer cells in mice [0.03%]
Bruceajavaniaca油乳剂可改善Lewis肺癌细胞诱导的小鼠恶病质症状
Chao Chen,Binbin Wang
Chao Chen
This study was conducted to evaluate the efficacy and possible mechanism of Brucea javanica oil emulsion (BJOE) on cachexia, by observing changes in related indexes in mice with cachexia and identifying the genes responsible based on gene c...
Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer's disease? [0.03%]
可降解的聚乳酸-羟基乙酸共聚物-红参皂苷Rg3纳米递送体系的神经保护作用：阿尔茨海默病潜在的纳米药物治疗？
Ravikumar Aalinkeel,Hilliard L Kutscher,Ajay Singh et al.
Ravikumar Aalinkeel et al.
It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an ...
Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction [0.03%]
化学反应生成的气体微泡介导的超声药物传输
Sungmun Lee,Leena Al-Kaabi,Aurélie Mawart et al.
Sungmun Lee et al.
Highly echogenic and ultrasound-responsive microbubbles such as nitrogen and perfluorocarbons have been exploited as ultrasound-mediated drug carriers. Here, we propose an innovative method for drug delivery using microbubbles generated fro...
Brain targeted delivery of mucoadhesive thermosensitive nasal gel of selegiline hydrochloride for treatment of Parkinson's disease [0.03%]
盐酸司来吉兰粘附热敏鼻凝胶的制备及对帕金森病的大脑靶向递送研究
Vinay Sridhar,Sarika Wairkar,Ram Gaud et al.
Vinay Sridhar et al.
Selegiline hydrochloride (SL), is an anti-Parkinson's agent, has low-oral bioavailability due to its high first pass metabolism and scarce oral absorption. In the present study, SL mucoadhesive nasal thermosensitive gel (SNT-gel) was prepar...
Effective antigen delivery via dual entrapment in erythrocytes and autologous plasma beads [0.03%]
有效通过红细胞和自身血浆珠双重封装传递抗原
Munazza Tamkeen Fatima,Ejaj Ahmad,Mehboob Hoque
Munazza Tamkeen Fatima
Fibrin-based polymeric systems have now emerged as efficient carriers of drugs, growth factors, genes, and cells. Earlier, we have reported fibrin-based plasma beads (PB), prepared from clotted whole plasma, as an efficient system for the c...
Topical delivery of TRPsiRNA-loaded solid lipid nanoparticles confer reduced pain sensation via TRPV1 silencing, in rats [0.03%]
载有TRPV1 siRNA的固脂体纳米粒通过沉默TRPV1达到减少疼痛的作用
Gaurav Sharma,Kanwaljit Chopra,Sanjeev Puri et al.
Gaurav Sharma et al.
Present work describes a novel composition for encapsulating TRPsiRNA (TRPV1-targeting siRNA) within lipid-matrix (4:1::glyceryl behnate:stearic acid) of SLNs, using suitably modified cold high-pressure homogenisation technique. Optimisatio...
ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement [0.03%]
一种衍生肽包被的聚合物纳米载体的目标定位、细胞内运输及溶酶体酶替代的活性功能(ICAM-1靶向)
Carmen Garnacho,Silvia Muro
Carmen Garnacho
Enzyme replacement is a viable treatment for diseases caused by genetic deficiency of lysosomal enzymes. However, suboptimal access of enzymes to target sites limits this strategy. Polymer nanocarriers (NCs) coated with antibody against int...
Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study [0.03%]
利用随机氨基酸延伸优化可主动穿过鼓膜的肽类物质——噬菌体展示研究
Arwa Kurabi,Daniel Schaerer,Lisa Chang et al.
Arwa Kurabi et al.
Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for ...
Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo [0.03%]
阳离子脂质体共封装SMAC模拟物和zVAD，使用新型脂质双层融合负载MLKL-pDNA以抑制体内肿瘤生长
Dan Sun,Linshu Zhao,Junzhong Lin et al.
Dan Sun et al.
The increase in multidrug resistance among colon cancer cells presents a challenge for the development of effective therapies. Small-molecule analogues of second mitochondria-derived activator of caspase (SMAC) mimetic in association with m...
Rajesh R Wakaskar
Rajesh R Wakaskar
Nanoparticles govern an all-important role, in this day and age, in determining the tissue distribution of either hydrophobic or hydrophilic anti-cancer drugs by encapsulating them or by covalent attachment. The whole purpose is to systemat...