Selective induction of apoptosis in MCF7 cancer-cell by targeted liposomes functionalised with mannose-6-phosphate [0.03%]
甘露糖-6-磷酸修饰的靶向脂质体诱导MCF7癌细胞凋亡的作用
Cristina Minnelli,Laura Cianfruglia,Emiliano Laudadio et al.
Cristina Minnelli et al.
Liposomes are versatile platforms to carry anticancer drugs in targeted drug delivery; they can be surface modified by different strategies and, when coupled with targeting ligands, are able to increase cellular internalisation and organell...
Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy [0.03%]
用于癌症细胞影像及治疗的多柔比星缀合的D-氨基葡萄糖和叶酸双功能化InP/ZnS量子点
Zahra Ranjbar-Navazi,Morteza Eskandani,Mohammad Johari-Ahar et al.
Zahra Ranjbar-Navazi et al.
Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised with folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-fu...
Poly-glutamic dendrimer-based conjugates for cancer vaccination - a computational design for targeted delivery of antigens [0.03%]
用于癌症免疫治疗的聚谷氨酸树状分子共轭体的计算机辅助设计及靶向输送抗原研究
L I F Moura,N Martinho,L C Silva et al.
L I F Moura et al.
Computational techniques are useful to predict interaction models and molecular properties for the design of drug delivery systems, such as dendrimers. This work evaluated the impact of surface modifications of mannosamine-conjugated multif...
A novel αVβ3 ligand-modified HPMA copolymers for anticancer drug delivery [0.03%]
一种新的αVβ3配体修饰的HPMA共聚物用于抗癌药物输送
Fengling Wang,Lian Li,Wei Sun et al.
Fengling Wang et al.
The integrin αVβ3 receptor emerged as one of the most promising targets owing to its high expression on the surface of various malignant tumour cells and tumour angiogenesis endothelial cells, but with little expression in mature endothel...
Polymer therapeutics at a crossroads? Finding the path for improved translation in the twenty-first century [0.03%]
聚合物药物治疗何去何从？二十一世纪改善转化医学之路在哪里？
Ruth Duncan
Ruth Duncan
Despite the relatively small early investment, first generation 'polymer therapeutics' have been remarkably successful with more than 25 products licenced for human use as polymeric drugs, sequestrants, conjugates, and as an imaging agent. ...
Green fluorescent protein (GFP): is seeing believing and is that enough? [0.03%]
绿色荧光蛋白(GFP)：见即信吗？——仅见就够了吗？
Susan A Shorter,Marie W Pettit,Paul D R Dyer et al.
Susan A Shorter et al.
Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) fo...
Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study [0.03%]
用于紫杉醇连接的整合素靶向纳米聚合物系统：一项比较研究
Anat Eldar-Boock,Rachel Blau,Claudia Ryppa et al.
Anat Eldar-Boock et al.
The generation of rationally designed polymer therapeutics via the conjugation of low molecular weight anti-cancer drugs to water-soluble polymeric nanocarriers aims to improve the therapeutic index. Here, we focus on applying polymer thera...
Comparative Study
Journal of drug targeting. 2017 Nov-Dec;25(9-10):829-844. DOI:10.1080/1061186X.2017.1358727 2017
HIF-1α inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics [0.03%]
双乙烯茋和多缩醛衍生物对低氧前列腺癌细胞中HIF-1α的抑制作用：核磁共振代谢组学洞察
Ana Armiñán,Luís Mendes,Joana Carrola et al.
Ana Armiñán et al.
In this study, we have employed 1H NMR metabolomics to assess the metabolic responses of PC3 prostate tumour cells to hypoxia and to pharmacological HIF-1α inhibition by DES or its polyacetal conjugate tert-DES. Oxygen deprivation prompted...
HPMA copolymer-phospholipase C and dextrin-phospholipase A2 as model triggers for polymer enzyme liposome therapy (PELT) [0.03%]
HPMA共聚物-磷脂酶C和糊精-磷脂酶A2作为聚合酶脂质体治疗(PELT)的模型触发因素
Elaine L Ferguson,Anna Scomparin,Hanna Hailu et al.
Elaine L Ferguson et al.
'Polymer Enzyme Liposome Therapy' (PELT) is a two-step anticancer approach in which a liposomal drug and polymer-phospholipase conjugate are administered sequentially to target the tumour interstitium by the enhanced permeability and retent...
Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics [0.03%]
聚合物供体对纳米尺寸聚合物治疗实验性实体瘤的效果有改善作用
Milada Šírová,Veronika Horková,Tomáš Etrych et al.
Milada Šírová et al.
Polymer carriers based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers with incorporated organic nitrates as nitric oxide (NO) donors were designed with the aim to localise NO generation in solid tumours, thus highly increasing the e...