Roberta Cavalli,Luca Primo,Roberto Sessa et al.
Roberta Cavalli et al.
AGMA1, a prevailingly cationic, guanidine-bearing, linear, amphoteric polyamidoamine is an effective siRNA condensing agent. Here two AGMA1 samples of different molecular weight, i.e. AGMA1-5 and AGMA1-10 were evaluated as siRNA condensing ...
pH-sensitive polymersomes: controlling swelling via copolymer structure and chemical composition [0.03%]
ph敏感聚合物囊泡：通过共聚物结构和化学组成控制溶胀
Simone Villani,Renata Adami,Ernesto Reverchon et al.
Simone Villani et al.
pH-sensitive vesicles used as drug delivery systems (DDSs) are generally composed of protonable copolymers. The disaggregation of these nanoparticles (NPs) during drug release implies the dispersion of positively charged cytotoxic polyelect...
Silk nanoparticles: proof of lysosomotropic anticancer drug delivery at single-cell resolution [0.03%]
丝蛋白纳米颗粒：单细胞分辨率下酸性药物抗癌作用的证据
John D Totten,Thidarat Wongpinyochit,F Philipp Seib
John D Totten
Silk nanoparticles are expected to improve chemotherapeutic drug targeting to solid tumours by exploiting tumour pathophysiology, modifying the cellular pharmacokinetics of the payload and ultimately resulting in trafficking to lysosomes an...
Enhanced cell killing and apoptosis of oral squamous cell carcinoma cells with ultrasound in combination with cetuximab coated albumin microbubbles [0.03%]
低频超声及西妥昔单抗包载白蛋白微泡对口腔鳞癌细胞杀伤作用及诱导凋亡
Kyoichi Narihira,Akiko Watanabe,Hong Sheng et al.
Kyoichi Narihira et al.
Targeted microbubbles have the potential to be used for ultrasound (US) therapy and diagnosis of various cancers. In the present study, US was irradiated to oral squamous cell carcinoma cells (HSC-2) in the presence of cetuximab-coated albu...
Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential [0.03%]
具有改善的淋巴靶向潜力的达芦那韦的基于长链三酰基甘油的自纳米乳化油制剂(SNEOFs)研究
Babita Garg,Sarwar Beg,Ranjot Kaur et al.
Babita Garg et al.
The current studies entail systematic development of SNEOFs containing long-chain triglycerides for improving lymphatic targeting of darunavir for complete inhibition of HIV progression. As per QbD-oriented approach for formulation developm...
Juan Li,Bin Zhang,Chunwen Yue et al.
Juan Li et al.
Doxorubicin (DOX) is one of the most effective cytotoxic anticancer drugs and has been successfully applied in clinics to treat haematological malignancies and a broad range of solid tumours. However, the clinical applications of DOX have l...
Covalent immobilisation of transglutaminase: stability and applications in protein PEGylation [0.03%]
转谷氨酰胺酶的共价固定化：稳定性及其在蛋白质聚乙二醇化中的应用
Antonella Grigoletto,Anna Mero,Hiroki Yoshioka et al.
Antonella Grigoletto et al.
Microbial transglutaminase enzyme (mTGase) is an extremely useful enzyme that is increasingly employed in the food and pharmaceutical industries and as a tool for protein modification and tagging. The current study describes how we immobili...
General overview of lipid-polymer hybrid nanoparticles, dendrimers, micelles, liposomes, spongosomes and cubosomes [0.03%]
脂质-聚合物杂化纳米粒、树枝状分子、胶束、脂质体、海绵体及立方脂质体制剂的总体概述
Rajesh R Wakaskar
Rajesh R Wakaskar
In recent years, the wider use of nanotechnology has attracted greater attention from scientists in multi-disciplinary fields. Nanotechnological research has come a long way in the past decade, with major advances being made, both in terms ...
Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke [0.03%]
近期用于改善缺血性卒中溶栓的组织型纤溶酶原激活物靶向递送研究进展
Masumeh Zamanlu,Mehdi Farhoudi,Morteza Eskandani et al.
Masumeh Zamanlu et al.
Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetrat...
Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers [0.03%]
基于聚合物的纳米药物的生物物理研究：阳离子及阴离子PAMAM树状分子与脂质单层相互作用的研究
Marleen Wilde,Rebecca J Green,Michael R Sanders et al.
Marleen Wilde et al.
Understanding how polymers interact with biological membranes is important for the development of polymer-based therapeutics and wider biomedical applications. Here, biophysical methods (surface pressure measurements, external reflection FT...