Multifunctional micelle delivery system for overcoming multidrug resistance of doxorubicin [0.03%]
用于克服多柔比星多重耐药的多功能胶束递送系统
Li Qin,Lei Wu,Shanshan Jiang et al.
Li Qin et al.
Doxorubicin (DOX), as an anthracycline, plays an important role in chemotherapy. But multidrug resistance (MDR) tremendously retards the anticancer effect of DOX and results in the failure of chemotherapy. Multifunctional micelles emerge as...
Coenzyme Q10 and retinaldehyde co-loaded nanostructured lipid carriers for efficacy evaluation in wrinkles [0.03%]
共轭脂质体纳米载体负载辅酶Q10和视黄醛治疗皱纹的疗效评估
Kritika Nayak,Sameer S Katiyar,Varun Kushwah et al.
Kritika Nayak et al.
This study depicts coenzyme Q10 (CoQ10) and retinaldehyde (RAL) co-loaded nanostructured lipid carriers (NLCs); having activity on different targets of photoageing, which can overcome deficits of conventional topical dosage forms. The devel...
Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route? [0.03%]
药物模型聚合物治疗剂能否充分穿过关节软骨以成为可行的治疗途径？
Alison Powell,Bruce Caterson,Clare Hughes et al.
Alison Powell et al.
The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must tr...
Rajesh R Wakaskar
Rajesh R Wakaskar
Successful ushering of nanomedicine has shown immense potential in advancing cancer treatment regimens. The unique characteristics of nanoparticles such as their optimal size, shape, efficient surface to volume ratio, surfaces that can be o...
Nanocarriers for brain specific delivery of anti-retro viral drugs: challenges and achievements [0.03%]
抗逆转录病毒药物纳米载体特异性递送至大脑：挑战与突破
Nila Mary Varghese,Venkatachalam Senthil,Shailendra K Saxena
Nila Mary Varghese
HIV/AIDS is a global pandemic and the deleterious effects of human immunodeficiency virus in the brain cannot be overlooked. Though the current anti-retro viral therapy is able to reduce the virus load in the peripheral tissues of the body,...
Lysosomal targeting strategies for design and delivery of bioactive for therapeutic interventions [0.03%]
溶酶体靶向策略的设计及生物活性药物的递送用于治疗干预
Ankur Sharma,Kalpesh Vaghasiya,Eupa Ray et al.
Ankur Sharma et al.
Lysosomes are of particular interest for the design and delivery of pH-dependent pro-drugs, enhancing selectivity and developing strategies to inhibit drug degradation inside the cells. There is great potential to bring intracellular drug d...
Rabia Gul,Naveed Ahmed,Kifayat Ullah Shah et al.
Rabia Gul et al.
Nanotechnology has burgeoned over last decade exploring varieties of novel applications in all areas of science and technology. Utilisation of bio-friendly polymers for engineering nanostructures (NS) improves safety and efficacy in drug de...
Ronit Satchi-Fainaro,María J Vicent,Simon Richardson
Ronit Satchi-Fainaro
Annabelle Herrington-Symes,Ji-Won Choi,Steve Brocchini
Annabelle Herrington-Symes
Increasingly complex proteins can be made by a recombinant chemical approach where proteins that can be made easily can be combined by site-specific chemical conjugation to form multifunctional or more active protein therapeutics. Protein d...