A new nanoemulsion formulation improves antileishmanial activity and reduces toxicity of amphotericin B [0.03%]
一种新的纳米乳液配方可提高两性霉素B的抗利什曼病活性并降低其毒性
Délia Chaves Moreira Dos Santos,Marselle Leite Silvério de Souza,Eliane Morais Teixeira et al.
Délia Chaves Moreira Dos Santos et al.
This work aimed to optimise a new nanoemulsion (NE) formulation loaded with Amphotericin B (AmB) and to evaluate its in vivo antileishmanial activity and in vitro haemolytic toxicity. The influence of gradual increases in pressure, using a ...
Comparative Study
Journal of drug targeting. 2018 Apr;26(4):357-364. DOI:10.1080/1061186X.2017.1387787 2018
Hiroshi Maeda
Hiroshi Maeda
History of the EPR (enhanced permeability and retention) effect is discussed, which goes back to the analyses of molecular pathology in bacterial infection and edema (extravasation) formation. The first mediator we found for extravasation w...
Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice [0.03%]
一种用于小鼠体内控制组织分布的纳米结构DNA载入磷酰二胺单体摩尔核苷酸的构建方法
Yosuke Takahashi,Yuki Araie,Daiki Nomura et al.
Yosuke Takahashi et al.
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides used in the treatment of neuromuscular diseases. Their major drawbacks are high blood clearance and poor cellular delivery. Previously, we demon...
Comparative Study
Journal of drug targeting. 2018 Apr;26(4):373-381. DOI:10.1080/1061186X.2017.1387789 2018
The promising potentials of capped gold nanoparticles for drug delivery systems [0.03%]
受控的金纳米颗粒在药物传输中的潜在应用
Kamyar Khoshnevisan,Maryam Daneshpour,Mohammad Barkhi et al.
Kamyar Khoshnevisan et al.
Fabrication and characterisation of gold nanoparticles (GNPs) through reducing agents and different capped agents are one of their most attractive applications in biomedicine. GNPs are coated using various agents such as carbohydrate, amino...
A nano-liposome vaccine carrying E75, a HER-2/neu-derived peptide, exhibits significant antitumour activity in mice [0.03%]
携带HER-2/ne癌肽E75的纳米脂质体疫苗可显著抑制小鼠肿瘤生长
Atefeh Arab,Javad Behravan,Atefeh Razazan et al.
Atefeh Arab et al.
E75 (HER-2/neu-369-377), is an immunogenic peptide which is highly expressed in breast cancer patients. The purpose of this study was to develop an effective vaccine delivery/adjuvant system by attachment of this peptide to the surface of l...
Comparative Study
Journal of drug targeting. 2018 Apr;26(4):365-372. DOI:10.1080/1061186X.2017.1387788 2018
Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system: preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics [0.03%]
基于热磁双响应体系的羟基喜树碱载药脂质体：制备、体内外抗肿瘤活性及微透析法灌注瘤药代动力学研究
Hai-Mei Zhu,Jin-Hui Gu,Yi Xie et al.
Hai-Mei Zhu et al.
Due to the absence of lactone form of hydroxycamptothecin, the commercially available hydroxycamptothecin injection exhibits inefficient therapeutic effects. In this study, we constructed a novel delivery system (thermosensitive magnetic li...
Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery [0.03%]
采用对流增强给药控制释放脂质体载替莫唑胺治疗脑瘤
Chung-Yin Lin,Rui-Jin Li,Chiung-Yin Huang et al.
Chung-Yin Lin et al.
Convection-enhanced delivery (CED) is a promising technique for the delivery of drugs directly into the central nervous system (CNS) and, more specifically, the brain. CED can increase drug concentration within a brain tumour, thereby impro...
Ummarah Kanwal,Nadeem Irfan Bukhari,Muhammad Ovais et al.
Ummarah Kanwal et al.
Doxorubicin (DOX) is the most effective chemotherapeutic drug developed against broad range of cancers such as solid tumours, transplantable leukemias and lymphomas. Conventional DOX-induced cardiotoxicity has limited its use. FDA approved ...