Micellar formulations of Crizotinib and Dasatinib in the management of glioblastoma multiforme [0.03%]
用于多形性胶质母细胞瘤治疗的Crizotinib和Dasatinib微乳液配方
Khaled Greish,Anfal Jasim,Neha Parayath et al.
Khaled Greish et al.
Glioblastoma multiforme (GBM) defies the currently practiced management of radiotherapy, chemotherapy and surgery and hence, it is associated with a high fatality rate with a median survival of 14.6 months. In our previous work investigatin...
Pendant HDAC inhibitor SAHA derivatised polymer as a novel prodrug micellar carrier for anticancer drugs [0.03%]
一种用于抗癌药物的新型前药聚合物载体——带有HDAC抑制剂SAHA修饰的两亲性嵌段共聚物
Jieni Xu,Jingjing Sun,Pengcheng Wang et al.
Jieni Xu et al.
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi) approved by FDA for the treatment of cutaneous T cell lymphoma, is a promising anticancer drug for various cancers with a unique mode of action. However, it dem...
Comparative Study
Journal of drug targeting. 2018 Jun-Jul;26(5-6):448-457. DOI:10.1080/1061186X.2017.1419355 2018
Macrophages as an active tumour-targeting carrier of SN38-nanoparticles for cancer therapy [0.03%]
巨噬细胞作为SN38-纳米颗粒的主动肿瘤靶向载体用于癌症治疗
Zhangdan Huang,Xuanrong Sun,Xiangrui Liu et al.
Zhangdan Huang et al.
Taking advantage of their enhanced permeability and retention (EPR) effect, nanomedicines have been extensively studied for targeted drug delivery to tumour tissues. However, tumour heterogeneity restricts the EPR effect and drug penetratio...
Comparative Study
Journal of drug targeting. 2018 Jun-Jul;26(5-6):458-465. DOI:10.1080/1061186X.2017.1419359 2018
Docetaxel-carboxymethylcellulose nanoparticles ameliorate CCl4-induced hepatic fibrosis in mice [0.03%]
紫杉醇-羧甲基纤维素纳米粒对四氯化碳致小鼠肝纤维化的治疗作用研究
Chih-Chun Chang,Yang Yang,Dong-Yu Gao et al.
Chih-Chun Chang et al.
Chronic liver diseases have recently garnered substantial attention as a leading cause of death around the world. During the progression of liver fibrosis/cirrhosis induced by chronic liver injury, hepatic stellate cells (HSCs) play key rol...
Local drug delivery in the urinary tract: current challenges and opportunities [0.03%]
泌尿道局部药物递送：目前的挑战和机遇
Rahul Mittal,Debbie R Pan,James M Parrish et al.
Rahul Mittal et al.
Drug delivery is an important consideration in disease treatment. There are many opportunities for novel methods and technologies to hold promising roles in overcoming traditional obstacles. Delivery systems functionalised to boast synergis...
Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles [0.03%]
超声波响应纳米气泡将5-氟尿嘧啶和抗坏血酸靶向输送到大脑的评估研究
Yusuke Miura,Yuki Fuchigami,Masayori Hagimori et al.
Yusuke Miura et al.
Recently, ultrasound-induced drug delivery into the brain using bubble formulations has been developed. After the brain delivery, however, the information on pharmacokinetics of hydrophilic drugs in the brain is lacking. In this study, to c...
Functionalised nanomaterials for eradication of CSCs, a promising approach for overcoming tumour heterogeneity [0.03%]
克服肿瘤异质性的功能性纳米材料消除CSCs的有希望的方法
Leila Farahmand,Behrad Darvishi,Malihe Salehi et al.
Leila Farahmand et al.
Today, intratumoural heterogeneity has been recognised as one of the main causes of cancer treatment failure and drug resistance development through which multiple mechanisms are simultaneously involved. From the broad diversity of cells pr...
Enhanced selective cellular uptake and cytotoxicity of epidermal growth factor-conjugated liposomes containing curcumin on EGFR-overexpressed pancreatic cancer cells [0.03%]
表皮生长因子连接的姜黄素载脂体制备及其对高表达EGFR胰腺癌细胞的选择性摄取和细胞毒作用研究
Uyen Minh Le,Amanda Hartman,Gopalakrishna Pillai
Uyen Minh Le
Pancreatic cancer is one of the most malignant cancers with a high mortality rate. Some types of pancreatic cancer cells overexpress epidermal growth factor receptor (EGFR), which is a potential target for anticancer agents. In this study, ...
Phytochemical based nanomedicines against cancer: current status and future prospects [0.03%]
基于植物化学物质的纳米药物抗肿瘤研究：现状与前景
Md Rizwanullah,Saima Amin,Showkat Rasool Mir et al.
Md Rizwanullah et al.
Cancer continues to be one in all the leading reasons for death worldwide. The mean cancer survival through standard therapeutic strategies has not been significantly improved over the past few decades. Hence, alternate remedies are needed ...
Sildenafil citrate improves the delivery and anticancer activity of doxorubicin formulations in a mouse model of breast cancer [0.03%]
硫酸西地那非通过小鼠乳腺癌模型改善多柔比星药物递送及抗癌活性
Khaled Greish,Maryam Fateel,Sara Abdelghany et al.
Khaled Greish et al.
Sildenafil is an approved drug for the treatment of erectile dysfunction. The drug exerts its action through the relaxation of smooth muscles and the modulation of vascular endothelial permeability. In this work, we tested whether the afore...