Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels [0.03%]
透明质酸修饰的多西环素联合Honokiol阳离子脂质体治疗乳腺癌及其消除血管生成模似通道的作用研究
Rui-Jun Ju,Lan Cheng,Xiao Qiu et al.
Rui-Jun Ju et al.
Background: Breast cancer is an alarming global public health problem and a main cause of cancer-related death in women. Systemic chemotherapy is the most widely used treatment for breast cancer. However, current chemothe...
Current update of a thermosensitive liposomes composed of DPPC and Brij78 [0.03%]
基于DPPC和Brij78的热敏脂质体当前版本的更新研究
Laurence Ho,Mehrdad Bokharaei,Shyh-Dar Li
Laurence Ho
Thermosensitive liposomes (TSLs) have been a prominent area of study in the discipline of tumour-targeted chemotherapeutics. The representative product of TSLs is ThermoDox® (DPPC/lyso-PC/PEG-lipid), which has advanced to Phase III clinica...
Liposomal formulation of glycosphingolipids from Sphingomonas paucimobilis induces antitumour immunity in mice [0.03%]
解脂放线菌糖神经酰胺的脂质体递送形式可诱导小鼠抗肿瘤免疫反应
Masood A Khan,Ahmed N Aljarbou,Yousef H Aldebasi et al.
Masood A Khan et al.
Natural Killer T (NKT) cells play an important role in host's anti-tumour immune response. Glycosphingolipids (GSLs) isolated from Sphingomonas paucimobilis have the ability to stimulate NKT cells. In this study, the activity of free GSLs o...
Structure optimisation to improve the delivery efficiency and cell selectivity of a tumour-targeting cell-penetrating peptide [0.03%]
结构优化可提高肿瘤靶向穿膜肽的递送效率和细胞选择性
Xue-Wei Cao,Xu-Zhong Yang,Xuan Du et al.
Xue-Wei Cao et al.
Cell-penetrating peptide (CPP) is used for the delivery of biomacromolecules across the cell membrane and is limited in cancer therapy due to the lack of cell selectivity. Epidermal growth factor receptor (EGFR) has been widely used in clin...
In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery [0.03%]
体外和体内评估聚合物微针的透皮给药性能
Bo Zhi Chen,Mohammad Ashfaq,Xiao Peng Zhang et al.
Bo Zhi Chen et al.
Microneedles (MNs) system for transdermal drug delivery has the potential to improve therapeutic efficacy, proving an approach that is more convenient and acceptable than traditional medication systems. This study systematically researched ...
Targeting oxidative stress through antioxidants in diabetes mellitus [0.03%]
抗氧化剂在糖尿病患者中的应用以应对氧化应激损伤
Parul Thakur,Ashwini Kumar,Awanish Kumar
Parul Thakur
The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diab...
Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook [0.03%]
纳米药物转化为纳米医学的启示及未来展望
Qingxin Mu,Jesse Yu,Lisa A McConnachie et al.
Qingxin Mu et al.
The concept of nanomedicine is not new. For instance, some nanocrystals and colloidal drug molecules are marketed that improve pharmacokinetic characteristics of single-agent therapeutics. For the past two decades, the number of research pu...
Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery [0.03%]
脂质包裹磷酸钙纳米颗粒及其药物递送多功能平台研究进展
Jia-Lin Huang,Hong-Zhuan Chen,Xiao-Ling Gao
Jia-Lin Huang
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal...
Shiying Wang,John A Hossack,Alexander L Klibanov
Shiying Wang
For contrast ultrasound imaging, the most efficient contrast agents comprise highly compressible gas-filled microbubbles. These micrometer-sized particles are typically filled with low-solubility perfluorocarbon gases, and coated with a thi...
The development of stimuli-responsive polymeric micelles for effective delivery of chemotherapeutic agents [0.03%]
刺激响应性聚合物胶束的开发用于有效递送化疗药物
Yimu Li,Aihua Yu,Lingbing Li et al.
Yimu Li et al.
Stimuli-responsive polymeric micelles, a novel category of polymeric micelles with response to endogenous or exogenous environments, show variable physicochemical properties as the variation of endogenous or exogenous circumstances. Because...