Kejing Lao,Naichun Ji,Xiaohua Zhang et al.
Kejing Lao et al.
Alzheimer's disease (AD) is a chronic neurodegenerative disease, which is considered as one of the most intractable medical problems with heavy social and economic costs. The current drugs for AD, including acetylcholinesterase inhibitors (...
Lingyun Yi,Yanan Zhang,Xiaoqun Shi et al.
Lingyun Yi et al.
In recent years, graphene oxide (GO) nanomaterials have attracted wide attention due to their large surface area, strong light sensitivity and good biocompatibility in cancer treatment. The rich oxygen-containing functional groups on the su...
Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors [0.03%]
分枝杆菌蛋白酪氨酸激酶PtkA通过酪氨酸对PtpA进行磷酸化，并被一组新型抑制剂所阻滞机制研究
Swati Jaiswal,Aditi Chatterjee,Sapna Pandey et al.
Swati Jaiswal et al.
Phosphorylation and dephosphorylation are the key mechanisms for mycobacterial physiology and play critical roles in mycobacterial survival and in its pathogenesis. Mycobacteria evade host immune mechanism by inhibiting phagosome - lysosome...
Chaopin Yang,Yue Li,Meng Du et al.
Chaopin Yang et al.
As a non-invasive and real-time diagnostic technique, ultrasound has provided a novel strategy for targeted treatment. With the rapid development of ultrasonic technique and ultrasound contrast agents (UCAs), spatiotemporally controllable a...
Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models [0.03%]
一种抗CD56抗体药物偶联物promiximab-MMAE的制备及其在小细胞肺癌异种移植瘤模型中的抗肿瘤活性评估
Lin Yu,Yuqin Yao,Yuxi Wang et al.
Lin Yu et al.
Antibody-drug conjugates (ADCs) have been successfully applied clinically as target drugs for cancer. In this study, anti-neural cell adhesion molecule also called CD56 antibody-monomethyl auristatin E (MMAE) conjugate named Promiximab-MMAE...
Tf ligand-receptor-mediated exenatide-Zn2+ complex oral-delivery system for penetration enhancement of exenatide [0.03%]
用于艾塞那肽渗透增强的艾塞那肽-锌₂₊ 复合物口服递送系统
Liping Zhang,Yanan Shi,Yina Song et al.
Liping Zhang et al.
Safe and effective oral delivery of peptide is a challenge. Here, we used exenatide and zinc ions (Zn2+) to form a complex to explore a meaningful oral-targeted drug-delivery system. Polyethylene glycol-poly(lactic acid-co-glycolic acid) (P...
Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer [0.03%]
靶向三阴乳腺癌STAT3信号通路的新型抑制剂BT354
Yue Chen,Ming Ji,Shen Zhang et al.
Yue Chen et al.
Inhibition of the signal transducer and activator of transcription 3 (STAT3) signalling pathway has been considered as a novel therapeutic strategy to treat human cancers with constitutively active STAT3. In this study, we screened 1563 com...
RGD peptide-based non-viral gene delivery vectors targeting integrin αvβ3 for cancer therapy [0.03%]
基于RGD肽的非病毒基因传递载体靶向整合素αvβ3用于癌症治疗
Shuang Fu,Xiaodong Xu,Yu Ma et al.
Shuang Fu et al.
Integrin αvβ3 is restrictedly expressed on angiogenic blood vessels and tumour cells. It plays a key role in angiogenesis for tumour growth and metastasis. RGD peptide can specifically recognise the integrin αvβ3, which serves as target...
A multifunctional nanoparticle constructed with a detachable albumin outer shell and a redox-sensitive inner core for efficient siRNA delivery to hepatocellular carcinoma cells [0.03%]
一种多功能纳米颗粒，通过可拆卸的白蛋白外壳和氧化还原敏感的核心有效递送siRNA到肝细胞癌细胞中
Bohui Xu,Yan Xu,Gaoxing Su et al.
Bohui Xu et al.
Successful delivery of small interfering RNA (siRNA) into the cytoplasm of target cells relies on biocompatible and efficient vectors. In this study, a novel multifunctional core/shell nanoparticle [CS-SS-9R/BSA-c(RGDyK)] was developed to e...
Targeting pulmonary tuberculosis using nanocarrier-based dry powder inhalation: current status and futuristic need [0.03%]
基于纳米载体的干粉吸入治疗肺结核现状及未来趋势
Tulshidas S Patil,Ashwini S Deshpande,Shirish Deshpande et al.
Tulshidas S Patil et al.
Tuberculosis (TB) is a disease caused by the pathogen Mycobacterium tuberculosis. Prolonged administration of high dose antibiotics using oral and injectable routes and their associated side effects show limitations to successful treatment ...