Delivery of disulfiram by Copper-doped mesoporous silica nanoparticles in combination with doxycycline for treating colorectal cancer liver metastasis [0.03%]
联合多西环素通过掺铜中孔二氧化硅纳米粒子递送双硫仑治疗结直肠癌肝转移
Yidan Zhang,Bin Xiong,Siyan Zhang et al.
Yidan Zhang et al.
Colorectal cancer liver metastasis (CCLM) remains a major therapeutic challenge due to chemoresistance and dose-limiting toxicities of conventional therapies. This study developed a copper-doped mesoporous silica nanoparticle (DSF@Cu-MSNs-B...
Mitochondria-targeted nanocarriers for smart response delivery of natural products: A Review [0.03%]
线粒体靶向的纳米递送系统用于天然产物的智能响应释放：综述
Jiansheng Cao,Wenfei Lu,Ying Lv et al.
Jiansheng Cao et al.
Mitochondrial dysfunction is closely associated with the onset and progression of various major diseases, including cancer and neurodegenerative disorders. The design of smart nanomaterial-natural product composite systems offers an innovat...
SKQ1: a mitochondria-targeted antioxidant with therapeutic potential [0.03%]
SKQ1：一种具有治疗潜力的线粒体靶向型抗氧化剂
Ruolan Wu,Yuan Wu
Ruolan Wu
Mitochondria-targeted antioxidants can selectively accumulate within mitochondria at low doses, thereby significantly enhancing therapeutic efficiency while minimizing potential side effects. SKQ1, a novel mitochondria-targeted antioxidant,...
A Dual-Action Nanoemulsified Mucoadhesive Polymeric Buccal Film of Curcumin-Lidocaine: Non-Invasive targeting Oral Mucositis Treatment via MMP-9 and NF-κβ Pathways [0.03%]
一种双效纳米乳化黏膜聚合颊胶片（姜黄素利多卡因）：通过MMP-9和NF-κβ途径非侵入靶向口腔粘膜炎治疗
Sammar Fathy Elhabal,Marwa Saeed Farahat,Mahmoud H Teaima et al.
Sammar Fathy Elhabal et al.
Oral mucositis (OM) is a debilitating condition that typically results from chemotherapy or radiotherapy, causing painful ulceration and inflammation in the oral cavity. This work optimized and tested a dual-action mucoadhesive buccal film ...
Buspirone Hydrochloride: A Potential Regulator of PD-L1 for Enhanced Antitumor Activity in Melanoma-Bearing Mice [0.03%]
盐酸布斯帕可能具有调节小鼠黑色素瘤PD-L1的作用以增强其抗肿瘤活性的效果
Jiaxin Geng,Kangle Wang,Sheping Zhang et al.
Jiaxin Geng et al.
PD-1/PD-L1 blockade therapy shows good efficacy in melanoma treatment. Yet, most patients still exhibit poor responses. Exploring more effective drugs remains worthwhile. In contrast to developing new drugs which entails a lengthy process, ...
Nanomedicines: An Update of Diagnostic and Therapeutic Applications in Multiple Cancers [0.03%]
纳米药物：多种癌症诊断和治疗应用的最新进展
Sani Jaysing Shinde,Priyanka,Manju Jakhar et al.
Sani Jaysing Shinde et al.
Cancer remains a major global health challenge, with existing diagnostic and therapeutic strategies often limited by poor selectivity, systemic toxicity, and resistance. Nanomedicine-a convergence of nanotechnology and molecular medicine-of...
Correction [0.03%]
改正错误
Published Erratum
Journal of drug targeting. 2026 Jan 2:1-2. DOI:10.1080/1061186X.2025.2610105 2026
Recent Advances in Theranostic-based Extracellular Vesicles in Cancer Stem Cell Diagnosis and Therapy [0.03%]
基于癌症干细胞诊断和治疗的治疗诊断型外泌体最新研究进展
Yunlan Huang,Linlin Chang,He Wang et al.
Yunlan Huang et al.
Cancer remains a leading cause of mortality worldwide, with treatment failure and disease recurrence often driven by cancer stem cells (CSCs), which constitute a resilient subpopulation within tumors characterized by self-renewal, different...
Venlafaxine suppressed PD-L1 expression through oxidative stress and improved anti-tumor immune responses in melanoma mice [0.03%]
伏硫西通过氧化应激抑制PD-L1的表达并改善小鼠黑色素瘤的抗肿瘤免疫反应
Mingyu Mo,Lirui Liang,Kairun Li et al.
Mingyu Mo et al.
Melanoma is an aggressive cutaneous malignancy characterized by high metastatic potential and poor prognosis. Oxidative stress plays a pivotal role in melanoma pathogenesis, as tumor cells exploit reactive oxygen species (ROS) to promote su...
Merve İnel PhD,Ayse Yildirim Dr,Bahadir Ozturk Prof et al.
Merve İnel PhD et al.
Organelle targeting systems are crucial for elucidating biological processes and pathologies associated with Golgi apparatus at the center of the secretory pathway. While the range of fluorescent probes developed for mitochondria and lysoso...