Lipid-based nanocarriers coupled with CO2 laser-mediated drug delivery enhance skin penetration and hair follicle targeting [0.03%]
基于脂质的纳米递送系统结合二氧化碳激光介导药物传输提高皮肤渗透性和毛囊定位性
Woan-Ruoh Lee,Wei-Ling Chou,Chien-Yu Hsiao et al.
Woan-Ruoh Lee et al.
The topical administration of hydrophilic drugs such as minoxidil and minocycline for alopecia and acne treatments remains unsatisfactory due to limited skin absorption and follicular uptake. The combination of physical and chemical enhance...
Nanocarrier based Topical Gel of Clofazimine: Advanced Therapeutic Strategy for the Treatment of Leprosy [0.03%]
用于治疗麻风病的氯法齐明纳米载体基外用凝胶：先进的治疗策略
Shailesh Chalikwar,Tanaya Dhole,Pankaj Jain et al.
Shailesh Chalikwar et al.
This study aims to formulate Clofazimine (CLOF)-loaded nanostructured lipid carriers (NLCs) for transdermal application, thereby improving the overall efficacy of the drug. NLCs loaded with clofazimine were developed using biocompatible lip...
Preparation and Evaluation of Elastic Provesicular Chrysin Carriers: A Targeted Therapeutic Strategy for Mitigating Ulcerative Colitis [0.03%]
弹性胶束状黄酮载体的制备及评价：治疗溃疡性结肠炎的靶向策略
Abeer Salama,Marwa Anwar Wagdi,Amany A El-Fadaly et al.
Abeer Salama et al.
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel syndrome characterized by inflammation and oxidative deterioration. Our study aimed to investigate provesicular formulations (Pro) as a novel carrier for chrysin (CR) to enh...
Solvent-Free Green Preparation of Niacinamide Niosomes for Targeting UVB-Induced Hyperpigmentation: QbD-Based Optimization and In Vivo Assessment [0.03%]
基于QbD的优化和体内评估的无溶剂绿色制备尼acinamide尼索姆，用于靶向UVB引起的色素沉着
Hibah M Aldawsari,Shaimaa M Badr-Eldin,Rana Bakhaidar et al.
Hibah M Aldawsari et al.
Hyperpigmentation is often driven by UV-induced inflammation and melanogenesis. This study aimed to develop a novel, eco-friendly niacinamide nano-delivery system to overcome the skin barrier and effectively target both inflammation and pig...
Formulation and Optimization of Leflunomide-Loaded NLC-Gel for Improved Skin Permeation and Anti-Inflammatory Efficacy [0.03%]
一种改善来氟米特经皮渗透和抗炎效果的纳米脂质体凝胶的制备及优化
Vivek Mewada,Jigar Shah,Aakash Kumar et al.
Vivek Mewada et al.
Arthritis is a chronic inflammatory disorder that impairs joint function and necessitates efficient localised treatment. This research aimed to formulate and optimise leflunomide-loaded nanostructured lipid carriers (NLCs) for topical deliv...
Thermosensitive, injectable, biocompatible epigallocatechin gallate liposomes/modified chitosan composite hydrogel for efficient skin repairing [0.03%]
一种用于高效皮肤修复的温度响应性、可注射、生物相容的表没食子儿茶素没食子酸酯脂质体/修饰壳聚糖复合水凝胶
Zeting Huang,Weishan Wen,Shengjun Huang et al.
Zeting Huang et al.
Epigallocatechin gallate (EGCG) exhibits remarkable bioactivities, notably enhancing wound healing via keratinocyte activation and re-epithelialization. However, its susceptibility to oxidation restricts its efficient application. To addres...
Design, Optimization, and In Vivo Assessment of In-Situ pH-Sensitive Quercetin Transbilosomes for the Treatment of Diabetes Mellitus-Associated Heart Failure [0.03%]
用于治疗糖尿病相关性心力衰竭的原位pH敏感型槲皮素转双层小体的设计、优化及体内评价
Wenxue Jin,Marwa H Elkarmalawy,Amr Gamal Fouad et al.
Wenxue Jin et al.
Quercetin (QCT) is an effective flavonoid that offers protection against diabetes mellitus-associated heart failure (HF) due to its antioxidant properties. The effectiveness of QCT is, however, constrained by its low bioavailability and poo...
The Role of MSC-Derived Exosomes in Immune Modulation and Regenerative Medicine [0.03%]
MSC来源的外泌体在免疫调节和再生医学中的作用
Surya Nath Pandey,Muhammad Afzal,Kavita Goyal et al.
Surya Nath Pandey et al.
Mesenchymal stem cells (MSC)-derived exosomes have been identified as highly potential, cell-free therapeutic agents that play pivotal roles in immune-based modulation in conjunction with regenerative medicine. These extracellular vesicles ...
Modified proposomes as a novel intra-articular delivery approach for rheumatoid arthritis [0.03%]
改良型 proposome 作为治疗类风湿性关节炎的新型关节内给药方式
Moataz B Zewail,Gihan F Asaad,Sally A El Awdan et al.
Moataz B Zewail et al.
A novel intra-articular (IA) nanocarrier system for leflunomide (LEF) was developed using modified proposomes to enhance therapeutic efficacy in rheumatoid arthritis (RA). LEF was efficiently encapsulated within propylene glycol-based propo...
Triphenylphosphonium-Functionalized Cubosomes for Mitochondrial-Targeted Delivery of 5-Fluorouracil and Lycopene in Skin Cancer Therapy [0.03%]
用于皮肤癌治疗的5-氟尿嘧啶和番茄红素三苯基膦功能化囊泡递送体系
Mohd Shoab Ali,Tenzin Sonam Dongsar,Niladri Haldar et al.
Mohd Shoab Ali et al.
The importance of mitochondria in cancer is undeniable, as they serve as a vital center for energy metabolism and regulating apoptosis. Herein, we engineered cubosomes as a nanocarrier with encapsulation of the chemotherapeutic agent 5-fluo...