Targeted drug delivery of oxazolidine derivative AP9 using chitosan nanoparticles for neuroprotection in a BPA-induced zebrafish model [0.03%]
用于BPA诱导斑马鱼模型神经保护的噁唑烷衍生物AP9及其壳聚糖纳米粒给药研究
S P Ramya Ranjan Nayak,Aveeda Herold,Vajagathali Mohammed et al.
S P Ramya Ranjan Nayak et al.
This study evaluated neuroprotective potential of an oxazolidine derivative, (4-(4-methoxyphenyl)-3-(4-nitrophenyl)-1,2-oxazolidine) (named AP9), and its chitosan (Ch) nanoparticle formulation (AP9-Ch), utilizing an integrated in silico, in...
ROS-responsive Polyethylenimine-phenylboronic acid-Bovine serum Albumin nanoparticles for targeted siMETTL3 delivery in hepatocellular carcinoma treatment [0.03%]
一种用于靶向siMETTL3传递治疗肝癌的ROS响应型聚乙烯亚胺-苯硼酸-牛血清白蛋白纳米粒
Jingjing Hu,Ke Chen,Yang Chen et al.
Jingjing Hu et al.
Hepatocellular carcinoma (HCC) is highly aggressive and chemoresistant, severely limiting the clinical efficacy of current therapies. Methyltransferase-like 3 (METTL3), a key regulator of N6-adenosine methylation (m6A), is overexpressed in ...
Mucoadhesive and pH-Responsive Berberine-Bletilla Striata Polysaccharide Core-Shell Microspheres for Colon-Targeted Synergistic Therapy of Ulcerative Colitis [0.03%]
用于溃疡性结肠炎结肠靶向协同治疗的粘附性和pH响应性的小檗碱白及多糖核壳微球
Huiru Li,Lingfeng Sun,Wenjie Lu et al.
Huiru Li et al.
Although berberine possesses notable anti-inflammatory and antioxidant properties for ulcerative colitis (UC) treatment, its clinical utility is limited by poor oral bioavailability. To enhance berberine delivery, we engineered Eudragit® S...
"Exosome-Inspired Liposomal Nanocarriers for Precision Methotrexate Delivery in Rheumatoid Arthritis" [0.03%]
“启发于外泌体的脂质纳米载体用于类风湿性关节炎的甲氨蝶呤精准给药”
Gaurav Tiwari,Rao V,Praveen Katiyar et al.
Gaurav Tiwari et al.
Rheumatoid arthritis (RA) is a progressive autoimmune disorder marked by synovial inflammation and cartilage erosion. Conventional methotrexate (MTX) therapy suffers from poor joint targeting and systemic toxicity. This study developed exos...
Development and Evaluation of Intranasal Nanostructured Lipid Carriers Encapsulating Donepezil HCl and Caesalpinia bonduc Seed Extract for Targeting Alzheimer's Disease: in vitro and in vivo evaluation [0.03%]
用于靶向阿尔茨海默病的多奈哌齐盐酸和Caesalpinia bonduc种子提取物鼻内纳米结构脂质载体的开发与评估：体外和体内评价
Avinash Tekade,Rushikesh Shinde,Janhavi Nimbalkar et al.
Avinash Tekade et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. This study aimed to develop and optimize an intranasal nanostructured lipid carrier (NLC) system co-loaded with Donepezil Hydr...
RNA therapeutics and their delivery methods: a paradigm for haemophilia management [0.03%]
RNA药物及其递送方式在血友病治疗中的应用展望
Ali Rajabi Zangi,Ala Amiri,Fatemeh Eskandari et al.
Ali Rajabi Zangi et al.
Haemophilia management is currently undergoing a paradigm shift from traditional protein replacement to RNA modalities and their delivery. This review provides a critical analysis of RNA-based therapeutics (specifically small interfering RN...
Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model [0.03%]
罗通定诱导的帕金森病模型中BRCC3的基因沉默通过载有siRNA的非离子小脂体调节自噬和内质网应激
Çevik Gürel,Ezgi Tut,Gökçe Ceren Kuşçu et al.
Çevik Gürel et al.
Parkinson's Disease (PD) is a prevalent neurodegenerative disorder. Recent studies implicate BRCA1-/BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate th...
Paclitaxel-loaded Bone Acellular Extracellular Matrix Injectable Hydrogel for Osteosarcoma Treatment [0.03%]
载紫杉醇的骨无细胞基质注射型水凝胶用于治疗骨肉瘤
He Chen,Kaili Ye,Chaonan Zhang
He Chen
A novel local chemotherapy delivery system was developed to improve the therapeutic efficacy of paclitaxel (PTX) for osteosarcoma while reducing systemic toxicity, low bioavailability, and tumor recurrence. PTX-loaded polylactic-co-glycolic...
Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats [0.03%]
以P407/P188为促渗剂的盐酸文拉法辛鼻用热敏凝胶给药系统的研究及其在抑郁大鼠模型中的抗抑郁作用
Yili Wu,Yujia Zhang,Dong Li et al.
Yili Wu et al.
Objective: To develop and optimise a VEN nasal thermosensitive in-situ gel for reducing the first-pass effect and enhancing bioavailability. Methods: ...
Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer [0.03%]
一种用于皮肤癌有效治疗的富萘酚原儿茶酸曼醇化非离子胶束囊泡纳米凝胶的靶向传递系统
Nikita Verma,Swarnlata Saraf,Soniya Sarthi et al.
Nikita Verma et al.
Skin cancer is caused by excessive UVR exposure, which poses a serious health risk. The use of phytoconstituents as medicaments for the management of various diseases has been trending in recent years due to their fewer adverse effects than...