Self-nanoemulsifying drug delivery system (SNEDDS) as Nano-carrier framework for permeability modulating approaches of BCS class III drug [0.03%]
自纳米乳化递送系统(SNEDDS)作为BCS三类药物渗透调节方法的纳米载体框架
Amulya Jindal,Pankaj Kumar Sharma,Anoop Kumar
Amulya Jindal
The purpose of this review is to focus on the Self-Nanoemulsifying Drug Delivery System (SNEDDS) as an effective nanocarrier framework for permeability modulating approaches (PMA) of BCS class-III drugs and its challenges. Present review up...
The Role of PTP1B in Cardiometabolic Disorders and Endothelial Dysfunction [0.03%]
PTP1B在心血管代谢疾病和内皮功能障碍中的作用
Mona A Sawali,Muhammad Ammar Zahid,Shahenda Salah Abdelsalam et al.
Mona A Sawali et al.
Cardiovascular diseases (CVD) are a global health concern that accounts for a large share of annual mortality. Endothelial dysfunction is the main underlying factor that eventually leads to cardiovascular events. Recent studies have undersc...
From Adhesion to Invasion: The Multifaceted Roles of Mycobacterium tuberculosis Lipoproteins [0.03%]
从粘附到侵入：结核杆菌蛋白脂的多重角色
Min Li,Qiao Zhang,Yun Wang et al.
Min Li et al.
Tuberculosis (TB) is caused by Mycobacterium tuberculosis, which poses a significant threat to human health . Lipoproteins are predominantly found in the Mycobacterium tuberculosis cell wall during infection of the invading host. The cell w...
Preparation, in vitro and in vivo evaluation of phloretin-loaded TPGS/Pluronic F68 modified mixed micelles with enhanced bioavailability and anti-aging activity [0.03%]
负载木酚素TPGS/Pluronic F68修饰混合型micelles的制备及其体内外促吸收和抗衰老活性评价
Jiaying Li,Tingyuan Li,Mingjie Gong et al.
Jiaying Li et al.
Phloretin exhibits strong antioxidant and anti-aging properties by inhibiting mitochondrial oxidation of glutamate, succinic acid, and ascorbic acid. However, its clinical application is limited by poor aqueous solubility and low oral bioav...
Fatemeh Attarian,Ghazaleh Hatamian,Shamim Nosrati et al.
Fatemeh Attarian et al.
In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms of breast cancer like triple-negative breast cancer (TNBC). This review delves into the significant role of liposo...
Niosomes as a Targeted Drug Delivery system in the Treatment of Breast Cancer: Preparation, Classification, and Mechanisms of Cellular Uptake [0.03%]
尼奥斯作为乳腺癌治疗中的靶向药物传递系统：制备、分类和细胞摄取机制
Muneeb UrRahman,Hafiz Rashid Hussain,Habiba Akram et al.
Muneeb UrRahman et al.
Breast cancer remains one of the significant health issues across the globe, being diagnosed in millions of women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited...
Development and Optimization of Curcumin-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design and Evaluation of Its Efficacy in Modulating Morphine-Induced Conditioned Place Preference: In Vivo and In Silico Studies [0.03%]
负载姜黄素固体脂质纳米粒的开发及优化和其对吗啡诱导的地方偏爱行为模型效用的评价：体内和体外研究
Amirhossein Babaei,Hossein Ebrahimi,Tina ShokouhiKouchaksaraei et al.
Amirhossein Babaei et al.
Drug addiction, particularly to opioids like morphine, remains a pressing global health issue. Curcumin, a natural flavonoid, holds promise for treating neurological disorders, yet faces challenges such as poor solubility and limited bioava...
Local delivery of ibrutinib by folate receptor-mediated targeting PLGA-PEG nanoparticles to glioblastoma multiform: in vitro and in vivo studies [0.03%]
叶酸受体介导的PLGA-PEG纳米颗粒局部输送伊布替尼至多形性胶质母细胞瘤的体内和体外研究
Bahar Morshedi,Mehdi Esfandyari-Manesh,Fatemeh Atyabi et al.
Bahar Morshedi et al.
Glioblastoma multiforme (GBM) is a widespread and life-threatening kind of brain cancer, which has a high mortality rate. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, irreversibly adheres to a conserved cysteine residue of two enz...
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis [0.03%]
使用天冬氨酸偶联物开发加载了利那利肽的脂质体用于靶向骨骼给药以对抗骨质疏松症
Nikita Nirwan,Yakkala Prasanna Anjaneyulu,Yasmin Sultana et al.
Nikita Nirwan et al.
Osteoporosis is a common metabolic bone disorder that requires new treatment strategies. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor is a proven osteogenic agent in diabetes-linked bone loss. However, poor solubility, low oral b...
Pseudo ternary phase diagram based PEGylated nano-dispersion of linezolid to promote wound regeneration: An in vitro and in vivo evaluation [0.03%]
基于伪三元相图的利奈唑胺聚乙二醇纳米分散体系促进伤口愈合的体内外评价
Bani Kumar Jana,Ishita Singha,Nusalu Puro et al.
Bani Kumar Jana et al.
Open wounds are prone to bacterial infiltration mostly resistant strains like methicillin-resistant Staphylococcus aureus, which affects the healing of open wounds. Topical linezolid nano-dispersion using essential oils as nanoemulgel can i...