Understanding the role of Ethosomes in Rheumatoid Arthritis: Innovative Solutions to Challenges in Transdermal Delivery of Synthetic Drugs and Phytoconstituents [0.03%]
理解Ethosome在类风湿性关节炎中的作用：解决合成药物和植物有效成分经皮给药挑战的创新方案
Rohan Anchan,Anish Ghadi,Mohammed Ali Chauhan et al.
Rohan Anchan et al.
Rheumatoid Arthritis (RA), an autoimmune disease, is a chronic inflammatory disorder affecting the joints leading to severe damage and cartilage destruction. Current therapies for RA such as DMARDs, NSAIDs, glucocorticoids, and phytoconstit...
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment [0.03%]
重新定义肝细胞癌治疗：纳米技术与肿瘤免疫微环境相遇
Chuanliang Mi,Sai Liu,Zhida Chen
Chuanliang Mi
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, characterized by its complex pathogenesis and poor therapeutic outcomes. Despite recent advances in targeted molecular therapies, immune checkpoint inhibitors ...
Masoud Lahouty,Amirhossein Soleymanzadeh,Sama Kazemi et al.
Masoud Lahouty et al.
Esophageal cancer (EC) is among the most common illnesses globally, and its prognosis is unfavorable. Surgery, radiotherapy, and chemotherapy are the primary therapy options for EC. Despite the occasional efficacy of these traditional treat...
Patient-derived organoid models of malignant phyllodes tumors for drug sensitivity testing and identification of targeted therapeutic strategies [0.03%]
患者衍生的恶性垂体叶肿瘤类器官模型用于药物敏感性测试和识别靶向治疗策略
Jie Chen,Liangquan Liu,Yunxu Yang et al.
Jie Chen et al.
Background: Malignant phyllodes tumors (MPT) of the breast are rare fibroepithelial neoplasms. It exhibits rapid growth, large size, and a high local recurrence rate. ...
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches [0.03%]
溃疡性结肠炎中的白藜芦醇：治疗机制，动物模型证据和新型方法
Yukta Garg,Nandini Sharma,Shivang Saxena et al.
Yukta Garg et al.
Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it easily relapses, thus, providing...
Quercetin-loaded magnetic nanoparticles: A promising tool for antitumor treatment in human breast cancer cells [0.03%]
负载檞皮素的磁性纳米粒子：人类乳腺癌细胞抗肿瘤治疗的理想工具
Silvina Tiburzi,Virginia Lezcano,Gabriel Principe et al.
Silvina Tiburzi et al.
Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit its efficacy as an anticancer drug. To address this, we explored loading QUE onto a non-toxic nanocarrier. Thi...
Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus [0.03%]
人胰岛素类似物联合二甲双胍对新诊断2型糖尿病患者胰岛功能的影响研究
Hui Wang,Shang Li,Tianqi Zhao et al.
Hui Wang et al.
This trial evaluated the effects of insulin aspart (IAsp) and insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus (T2DM). A total of 96 T2DM patients were randomized into the control group (insulin de...
Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis [0.03%]
具有抗炎特性的生物启发性吞噬稳定纳米幽灵的发展用于管理溃疡性结肠炎中的炎症
Ahmed Mohsin Huran Al-Jawadri,Zahra Karami,Ismaeil Haririan et al.
Ahmed Mohsin Huran Al-Jawadri et al.
Background: New bio-mimetic approaches are needed to develop effective delivery systems for inflammation regulation in chronic diseases like ulcerative colitis, avoiding fast clearance by immune system. The cell membrane-...
2,2,6,6-tetramethylpiperidin-1-oxyl: A New Potential Targeted Ligand Based on Lipid Peroxidation for Targeted Drug Delivery [0.03%]
2,2,6,6-四甲基哌啶-1-氧基：一种基于脂质过氧化作用的新潜在靶向配体，用于靶向药物传递
Xiaofei Zhang,Guohao Yin,Minbo Lan et al.
Xiaofei Zhang et al.
The side effects of chemotherapy drugs have prompted the development of targeted therapies. Distinctive abundance of lipid peroxidation (LPO) in tumor cells represents a potential target for drug delivery. However, LPO - based targeted liga...
Investigation of Silicon Oxide Nanoparticle-Enhanced Self-Healing Hydrogel for Cartilage Repair and Regeneration in Rabbit Earlobe Models [0.03%]
硅氧化合物纳米粒子增强自愈水凝胶在兔耳廓模型中对软骨修复和再生的应用研究
Seyedeh-Sara Hashemi,Reza Alizadeh,Alireza Rafati et al.
Seyedeh-Sara Hashemi et al.
This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess hydrogel morphology, cell proliferation, and viability. The effectiveness of these hydrogels for cartilage repai...