Intranasal dalfampridine-loaded mucoadhesive polymeric nanoparticles for brain targeting: formulation and therapeutic evaluation in a cuprizone-induced demyelination model [0.03%]
一种新的氨磷汀鼻用给药递送系统用于治疗多发性硬化症：杯rizone诱导脱髓鞘模型的制备和疗效评价研究
Jaghatha Therassama,Justus Oliver Jaslin Edward,Somasundaram Arumugam et al.
Jaghatha Therassama et al.
The present study aimed to develop and comprehensively evaluate dalfampridine-loaded chitosan nanoparticles (DLM-CSNPs) for enhanced intranasal brain delivery in a cuprizone-induced demyelination model of multiple sclerosis (MS). The optimi...
Sweetmama Pradhan,Dinesh Kumar Sharma
Sweetmama Pradhan
Wound healing is a complex, dynamic, and multistep biological process involving haemostasis, inflammation, proliferation, and remodelling, which can be severely compromised in chronic, infected, or non-healing wounds. Conventional wound car...
Cell-derived nanomaterials for acute kidney injury: a pathophysiology-driven framework for precision delivery and multimodal therapy [0.03%]
细胞来源的纳米材料在急性肾损伤中的应用：一种基于病理生理学的精准递送和多模式治疗框架
Yibin Zheng,Qi Li,Yuting Liu et al.
Yibin Zheng et al.
Acute kidney injury (AKI) is a complex disease driven by the dynamic coupling of multiple pathological mechanisms. Current treatments remain primarily supportive, making it difficult to achieve precise regulation at key pathological junctur...
Design of a Novel Nano-Lipoidal Gel System for Topical Delivery of Hydroxychloroquine in Rheumatoid Arthritis [0.03%]
一种新型纳米脂质凝胶系统用于类风湿关节炎羟氯喹局部递送的设计
Ankit Raj,Pradip Nirbhavane,Ashish Dilip Sutar et al.
Ankit Raj et al.
Hydroxychloroquine (HCQ) is a disease-modifying anti-rheumatic drug (DMARD), widely used in management of rheumatoid arthritis. However, its moderate bioavailability and serious systemic adverse effects limit its therapeutic utility for lon...
"Dendrimer-Mediated Therapy and Recovery for Stroke: A Comprehensive Review" [0.03%]
基于树枝状大分子的脑卒中治疗及修复研究进展
Zainab Lafi,Sherine Asha,Rotana Walid Abu-Obaida
Zainab Lafi
Stroke is a leading cause of mortality and long-term disability worldwide, with ischemic stroke accounting for the majority of cases. Current therapies, including thrombolysis and supportive care, are limited by narrow therapeutic windows, ...
Chitosan-based nanocarriers in Alzheimer's disease therapy: Recent developments and future perspectives [0.03%]
基于壳聚糖的纳米递送系统在阿尔茨海默病治疗中的研究进展与未来前景
Dinesh Kumar Sharma,Chandra Shekhar Prasad
Dinesh Kumar Sharma
Alzheimer's disease (AD) is a neurological condition that worsens with time and causes behavioral problems, memory loss, and cognitive decline. It is a major global health concern. Alzheimer's complexity and the blood-brain barrier (BBB) li...
Application of small interfering RNAs and drug combination for pancreatic cancer therapy [0.03%]
胰腺癌治疗中针对microRNA的靶向疗法及联合用药策略研究
Chaoyang Zeng,Shu-Zhen Chen
Chaoyang Zeng
In recent years, pancreatic cancer has become one of the major causes of death among cancers. It has been confirmed that changes in the expression of various genes are important factors associated with the occurrence and development of panc...
Green synthesis and characterization of silver nanoparticles using Asparagus officinalis and their anti-inflammatory and antioxidant activities: in silico, in vitro, and in vivo studies [0.03%]
利用天门冬合成银纳米颗粒及其抗炎抗氧化活性：基于计算机模拟，体外和体内研究
Adil Sher,Ahmad Sohail,Adnan Gul et al.
Adil Sher et al.
Herbal medicines for managing prevalent health conditions, inflammatory disorders, and oxidative stress have attracted growing scientific attention. This study reports the green synthesis of silver nanoparticles (AgNPs) using Asparagus offi...
Nanoparticle-based insulin delivery: route-specific barriers, innovations, and therapeutic outcomes [0.03%]
基于纳米颗粒的胰岛素递送：途径特异性障碍、创新和治疗效果
Nusaiba K Al-Nemrawi,Sukaina Nimrawi,Emad Mustafa et al.
Nusaiba K Al-Nemrawi et al.
Diabetes mellitus (DM) remains a major global health challenge requiring life-long insulin therapy for glycemic control. While subcutaneous (SC) injection is the conventional route of insulin administration, its invasiveness and limited pat...
Michaela Patila,Mariana Angeli,Dimitrios P Gournis et al.
Michaela Patila et al.
Carbon dots have become one of the most versatile families of nanomaterials, distinguished by their exceptional photoluminescence, water dispersibility, and intrinsic biocompatibility. In the past five years, substantial advances have been ...