Breast cancer cell targeting of L-leucine-PLGA conjugated hybrid solid lipid nanoparticles of betulin via L-amino acid transport system-1 [0.03%]
通过L-氨基酸转运系统-1靶向叶酸连接的桦木醇混合固体脂质纳米粒子
Shilpa A Gajbhiye,Moreshwar P Patil
Shilpa A Gajbhiye
The aim of fabricating hybrid solid lipid nanoparticles (HSLN) was to enhance the delivery of betulin to triple negative beast cancer cells through the intravenous route via L-amino transporter system-1, using L-leucine-PLGA conjugate (Conj...
Engineered extracellular vesicle with RAGE-antagonist peptide for delivery of anti-miRNA155 oligonucleotides to inflammatory lung cells [0.03%]
一种工程化外泌体用于向炎症性肺细胞递送抗-miRNA155寡核苷酸及RAGE拮抗肽
Chuanyu Zhuang,Minji Kang,Jihun Oh et al.
Chuanyu Zhuang et al.
Acute lung injury (ALI) is an inflammatory lung disease. In lungs afflicted with ALI, microRNA-155 (miR-155) is over-expressed, inducing pro-inflammatory cytokines by inhibition of suppressor of cytokine signaling 1 (SOCS1). In addition, re...
Umar Abbasi,Mohd Zaid Khan,Mahak Fatima et al.
Umar Abbasi et al.
Nanoemulgels are an advanced innovation in dermatological formulations designed to treat various skin diseases. By combining the advantages of hydrogels and nanoemulsions, these hybrid systems optimize drug delivery and improve therapeutic ...
Emodin nanocrystals enhanced mucus penetration and ameliorated bleomycin-induced pulmonary fibrosis by pulmonary delivery [0.03%]
肺部给药纳米蒽嵌顿因素增强黏液穿透力并改善顺铂诱导的肺纤维化
Chenghao Zhang,Yihua Wang,Xinran Cui et al.
Chenghao Zhang et al.
Pulmonary fibrosis (PF) is a progressive interstitial disease characterized by extracellular matrix deposition and destruction of lung tissue structure. Emodin (Emo) is a natural active compound with anti-inflammatory and antioxidant proper...
Hedgehog signaling pathway inhibitors in the treatment of basal cell carcinoma: An Updated Review [0.03%]
基底细胞癌 hedgehog 信号通路抑制剂治疗的最新进展
Adela Markota Cagalj,Mislav Glibo,Valentina Karin-Kujundzic et al.
Adela Markota Cagalj et al.
Basal cell carcinoma (BCC) is the most common type of skin cancer that usually appears in sun-exposed body regions such as the head, trunk, and extremities. There are four main clinicopathological subtypes of BCC: nodular, superficial, morp...
S-nitrosoglutathione releasing nano-micron combination hydrogel enhances cutaneous wound healing via promoting angiogenesis and collagen deposition [0.03%]
S-硝基谷胱甘肽释放的纳米微米复合水凝胶通过促进血管生成和胶原沉积来增强皮肤伤口愈合
Ying Fan,Chuli Liao,Jie Li et al.
Ying Fan et al.
Nitric oxide (NO) is essential for wound healing, promoting angiogenesis and collagen deposition. This study investigates a novel dual-matrix nanocomposite hydrogel incorporating S-nitrosoglutathione (GSNO), a physiological NO donor, to enh...
The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer [0.03%]
细菌及其衍生物作为纳米颗粒癌症治疗输送系统潜在用途
Shiva Ahmadishoar,Samaa Mones Saeed,Morug Salih Mahdi et al.
Shiva Ahmadishoar et al.
Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, and electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, and specificity ...
Novel therapeutic approaches for non-small cell lung cancer: an updated view [0.03%]
非小细胞肺癌的新治疗途径：最新观点
Niloufar Orooji,Shabnam Babaei,Manouchehr Fadaee et al.
Niloufar Orooji et al.
Non-small cell lung cancer (NSCLC) continues to be one of the leading causes of cancer-related mortality globally. Most patients who undergo surgical procedures may encounter distant metastasis or local recurrence, necessitating supplementa...
Design and Formulation of Fast-Dissolving Microneedles for the Rapid Transdermal Delivery of Lorazepam [0.03%]
用于 lorazepam 快速透皮给药的快速溶解型微针的设计与配方
Punith M,Rajamma Aj,Sateesha Sb et al.
Punith M et al.
This study investigates lorazepam-loaded dissolving microneedles (LMNs) as a fast-acting and minimally invasive treatment for status epilepticus. The LMNs were developed using a micro-molding technique with an optimized combination of PVP K...
Methodological Advances in Liposomal Encapsulation Efficiency Determination: Systematic Review and Analysis [0.03%]
脂质体包封效率测定的方法学进展：系统回顾与分析
Jin-Ping Wang,Zi-Rui Huang,Cheng Zhang et al.
Jin-Ping Wang et al.
Liposomes represent a highly promising drug delivery platform for a wide range of pharmaceutical compounds. The encapsulation efficiency (EE) stands as a critical quality attribute for liposomal formulations. Accurate determination of EE re...