Machine Learning for Genomic Profiling and Drug Discovery in Personalised Lung Cancer Therapeutics [0.03%]
机器学习在个性化肺癌治疗的基因组分析及药物发现中的应用
Shaban Ahmad,Syed Naseer Ahmad Shah,Rafat Parveen et al.
Shaban Ahmad et al.
Lung cancer is a prevalent and lethal malignancy characterised by the uncontrolled growth of abnormal cells in lung tissues, often leading to functional impairment and metastasis. With approximately 2 million new cases and 1.8 million death...
Boosting Breast Cancer Immunotherapy through Targeted siRNA Delivery and Sequential Chemotherapy [0.03%]
通过靶向siRNA递送和序贯化疗增强乳腺癌免疫治疗
Naghmeh Jabarimani,Ehsan Khabazian,Bahar Morshedi et al.
Naghmeh Jabarimani et al.
Cancer continues to be a major public health challenge due to therapeutic resistance, rising incidence, and financial burden. Although anti-programmed cell death-ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment, its effica...
A novel furo[2,3- d] pyrimidine-based chalcone derivative (MMK-1931) loaded chitosomes as a potential cancer therapy in an Ehrlich ascites tumor model [0.03%]
一种新型的基于呋喃并吡啶--chalcone衍生物（mmk-1931）的壳聚糖小体作为厄里希腹水肿瘤模型中癌症治疗的潜在方法
Walaa A El-Dakroury,Moataz B Zewail,Mai A Mansour et al.
Walaa A El-Dakroury et al.
The pursuit of effective, non-invasive cancer therapies has propelled the development of oral delivery systems capable of overcoming the limitations of conventional chemotherapy. A novel furo[2,3-d] pyrimidine-based chalcone derivative, MMK...
A Pioneer Review on Lactoferrin as Versatile Macromolecular Ligand for Targeting Cancer: Recent Advances [0.03%]
一种针对癌症的多功能大分子配体乳铁蛋白的研究综述：最近的进展
Nidhi Sharma,Nousheen Khatoon,Mohammad Adnan Raza et al.
Nidhi Sharma et al.
This study critically examines recent developments in the use of lactoferrin, a multi-functional iron-chelating glycoprotein, as a macromolecular ligand for precision cancer therapy. The study highlights the molecular mechanism of lactoferr...
Polymyxin B Delivery Systems: Smart Solutions for Improved Antibacterial Activity and Reduced Toxicity [0.03%]
多粘菌素B递送系统：改善抗菌活性和降低毒性的智能解决方案
Ying Cheng,Mingdong Yang,Bin Lin et al.
Ying Cheng et al.
Polymyxin B (PMB) serves as the last-line drug for treating multidrug-resistant Gram-negative bacterial infections. However, its clinical application is limited due to significant nephrotoxicity and neurotoxicity. In recent years, smart dru...
Employing covalent organic framework (COF) as carrier in an aptamer-targeted theranostic nanoplatform: investigation of its therapeutic and diagnostic properties in vitro and in vivo [0.03%]
基于共价有机框架的适配体靶向治疗诊断一体化纳米平台的构建及体内外评价
Seyed Mojtaba Mashmoul Moghadam,Mohammad Ramezani,Mona Alibolandi et al.
Seyed Mojtaba Mashmoul Moghadam et al.
In this study, we developed a novel theranostic nanoplatform integrating a covalent organic framework (COF) with superparamagnetic iron oxide nanoparticles (SPIONs) for targeted cancer therapy and diagnosis. The system was engineered to co-...
Dongliang Liao,Tian Pu,Peng Tian
Dongliang Liao
The stroma plays a pivotal role in the development of prostate tumours. The tumour stroma includes different immune and stromal cells. Stromal cells can include fibroblasts, activated fibroblasts, endothelial cells, stem cells, etc. Immune ...
Nose-to-brain delivery of transferrin-modified carmustine-loaded iron nanoparticles for enhanced glioblastoma treatment [0.03%]
表面修饰转铁蛋白的卡莫司汀载铁纳米颗粒鼻脑递送以增强胶质母细胞瘤治疗效果
Hong Wang,Qingguo Ren,Guojian Wu et al.
Hong Wang et al.
Glioblastoma multiforme (GBM) remains a therapeutic challenge due to blood-brain barrier (BBB) restrictions and an immunosuppressive tumor microenvironment (TME) dominated by M2-polarized tumor-associated macrophages (TAMs). While carmustin...
Smart design and preclinical evaluation of folate-functionalized mesoporous nanoparticles for targeted paclitaxel delivery in cancer therapy [0.03%]
叶酸功能化介孔纳米粒的智能设计及其在癌症治疗中紫杉醇传递的药代动力学与药效学研究
Krishnaben Champanria,Prajesh Prajapati
Krishnaben Champanria
This work aims to assess mechanisms of synthesis of folate-conjugated mesoporous silica nanoparticles (MNPs) for targeted delivery of paclitaxel in cancer treatment. Paaclitaxel, while potent, suffers from poor solubility and severe side ef...
Off-target effects of the NADPH oxidase inhibitor mitoapocynin-encapsulated nanoparticles and free-drug oral treatment in a rat DFP model of neurotoxicity [0.03%]
包裹型细胞色素P450还原酶抑制剂纳米粒和自由药物口服给药的脱靶效应及其在稻瘟灵致神经毒性的大鼠模型中的作用
Christina Meyer,Claire Holtkamp,Tyler Harm et al.
Christina Meyer et al.
Acute exposure to diisopropylfluorophosphate (DFP), an organophosphate (OP), produces chronic neurological effects such as spontaneous seizures and behavioral comorbidities. Achieving optimal drug bioavailability in the brain by conventiona...