Design, Optimization and In Vivo Evaluation of Tazarotene Loaded Emulgel Formulation for the Treatment of Acne [0.03%]
用于治疗痤疮的塔拉鲁特醇载药Emulgel制剂的设计、优化及体内评价研究
Amit Pratap Singh,Sushil Kumar Kashaw,Vandana Soni
Amit Pratap Singh
Acne vulgaris is a common dermatological disorder with current treatments often limited to poor skin penetration, instability, irritation, and suboptimal therapeutic outcomes. There is a pressing need for advanced drug delivery systems that...
Harnessing Exosome-Based Drug Delivery for the Management of Pregnancy-Related Disorders: A New Frontier in Obstetric Therapeutics [0.03%]
外泌体递药系统管理妊娠相关疾病：妇产科治疗新前沿
Feihua Jin,Yaying Zhan,Shaomin Xu et al.
Feihua Jin et al.
Obstetric complications such as preeclampsia, preterm birth, and fetal growth restriction significantly impact maternal and neonatal health globally, contributing substantially to maternal and perinatal morbidity and mortality. These condit...
Comparison of a poloxamer-based thermally sensitive gel and an HPMC-based standard gel used to increase sildenafil citrate retention in the uterus [0.03%]
基于聚氧乙烯-聚氧丙烯-聚氧乙烯嵌段聚合物及羟丙基甲基纤维素凝胶增加西地那非子宫滞留的比较研究
Jinmei Ren,Shuxia Wang,Zhaoli Wu et al.
Jinmei Ren et al.
Objective: Sildenafil citrate (SC) could promote uterine lining development, leading to successful embryo implantation. Due to the low oral bioavailability of the first-pass elimination of SC, it is necessary to develop a...
Calpeptin Promotes Osteogenesis through the Dlx3-RUNX2 Pathway: In Vitro and In Vivo Evidence for a Dual-Action Osteoporosis Therapy [0.03%]
Calpeptin通过Dlx3-RUNX2途径促进成骨作用：体内外证据表明是一种治疗 osteoporosis 的双重作用疗法
Pengruofeng Liu,Zimo Zhang,Xinyi Lin et al.
Pengruofeng Liu et al.
Osteoporosis is a common systemic skeletal disease characterized by altered bone metabolism, decreased bone mass, deteriorated microstructure, and an increased risk of fractures. Current treatments primarily focus on inhibiting bone resorpt...
Efficacy and safety of valsartan-novasomes in the mitigation of atherosclerosis-associated diabetes mellitus: in vitro and in vivo assessment [0.03%]
缬沙坦新型体在改善动脉粥样硬化相关糖尿病方面的有效性和安全性：体外和体内评估
Tamer Mohamed Mahmoud,Mohammed Ayad Alboreadi,Ala Hussain Haider et al.
Tamer Mohamed Mahmoud et al.
Valsartan (VAL) offers protection against atherosclerosis-associated diabetes mellitus (AADM) due to its antioxidant properties. However, VAL is hindered by poor bioavailability and effectiveness, which can be attributed to its low water so...
Recent advancements in nanoparticle-based topical drug delivery systems for psoriasis treatment [0.03%]
基于纳米颗粒的银屑病治疗 topical 药物递送系统最新进展
Ritwik Mitra,Dinesh Kumar Sharma,Arnab Ghosh et al.
Ritwik Mitra et al.
Chronic autoimmune skin disorder known as psoriasis (PSO) is typified by the excessive proliferation of skin cells, which develops thick, red, and scaly patches on the skin's surface. These patches may be uncomfortable for people with this ...
Multi-Omics Approaches in Gene Therapy for Vascular Diseases: Bridging Genomics, Transcriptomics, and Epigenetics [0.03%]
血管疾病基因治疗的多组学方法：连接基因组学、转录组学和表观遗传学
Jianxin Dong,Ming Sun,Yanmei Li et al.
Jianxin Dong et al.
Vascular diseases such as atherosclerosis, aneurysms, and peripheral arterial disease remain leading causes of morbidity and mortality, with current treatments primarily managing symptoms rather than addressing underlying molecular drivers....
Ofirnoflast: A First-in-Class NEK7-Targeted Inhibitor of the NLRP3 Inflammasome [0.03%]
奥弗诺夫拉斯特：一种第一类NLRP3炎性小体NEK7靶向抑制剂
Alexis Mollard,Devan Bursey,William Burnett et al.
Alexis Mollard et al.
Ofirnoflast is a first-in-class, orally bioavailable NEK7 inhibitor currently undergoing Phase 2 clinical evaluation. It disrupts NLRP3 inflammasome assembly by targeting NEK7's scaffolding function-blocking complex formation independently ...
Novel therapeutic aspects of stem cell-derived extracellular vesicles in female reproductive disorders [0.03%]
干细胞源外泌体在女性生殖障碍疾病治疗中的新进展
Hadi Karimzadeh,Reza Aghaei,Amirreza Jourabchi et al.
Hadi Karimzadeh et al.
Infertility affects millions of women worldwide, with causes ranging from ovarian dysfunction to endometrial disorders. Conventional treatments, such as hormone therapy and assisted reproductive technologies (ART), often have limited succes...
Neuroprotective effect of rosuvastatin-loaded nanoemulsions against lipopolysaccharide-induced neuroinflammation and oxidative stress [0.03%]
罗苏伐他汀载药纳米乳对脂多糖致神经炎症和氧化应激的神经保护作用
Zahra Saberi,Neda Rostamkhani,Mohammadreza Saghatchi Zanjani et al.
Zahra Saberi et al.
Neuroinflammation is a pathophysiological feature of several neurological disorders, including Parkinson's disease, Alzheimer's disease and traumatic brain injury, resulting from various intrinsic and environmental triggers. However, effect...