Intravaginal Co-delivery of Myoinositol and Metformin via Dual MPPs-Loaded Gel for PCOS Amelioration: An In-vivo Study in a Rat Model [0.03%]
一种用于PCOS改善的双MPP凝胶负载系统的宫内协同投药体系：大鼠模型体内实验研究
Uzma Farooq,Nazeer Hasan,Ahsan Ali et al.
Uzma Farooq et al.
Polycystic ovarian syndrome is a highly prevalent, multifaceted endocrinopathy among reproductive women. Current therapies have limited therapeutic success and compliance owing to multiple complications. Here, we developed MPPs-Gel formulat...
Strategies of Overcoming Osimertinib Resistance in EGFR-mutated Non-small Cell Lung Cancer [0.03%]
第三代EGFR-TKI奥希替尼耐药机制及应对策略研究进展
Qiong Jiang,Yanxia Jin,Weidong Wang et al.
Qiong Jiang et al.
Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has significantly advanced the treatment of non-small cell lung cancer (NSCLC), particularly in patients who develop resistance to first-...
Chitosan-β-Glycerophosphate Thermo-gelling Microneedles for Transdermal Contraceptive Delivery of Levonorgestrel [0.03%]
用于透皮递送左炔诺孕酮的壳聚糖-β-甘油磷酸温凝胶微针
Chethan Kumar K B,Sateesha Sb,Ankith N A et al.
Chethan Kumar K B et al.
This study presents the development of dissolving microneedles (LMNs) incorporating a chitosan-β-glycerophosphate thermogelling system for sustained transdermal delivery of levonorgestrel (LNG) as a contraceptive. Polyvinylpyrrolidone K90 ...
Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies [0.03%]
对抗乳腺癌化疗耐药性的研究：探索肿瘤微环境、联合疗法和药物再定位策略
Shazia Sofi,Nusrat Jan,Gowhar Masoodi et al.
Shazia Sofi et al.
Chemoresistance in Breast Cancer is a challenge that remains paramount in its treatment. Chemoresistance mechanisms in this heterogeneous disease are complicated and have never been fully elucidated. Since the current therapies are insuffic...
Targeted delivery of anti-microRNA-21 oligonucleotides using chlorotoxin-engineered extracellular vesicles for treatment of glioblastoma [0.03%]
利用氯毒素工程外泌体靶向递送抗microRNA-21寡核苷酸治疗胶质母细胞瘤
Subin Kang,Mincheol Son,Minji Kang et al.
Subin Kang et al.
Glioblastoma is a devastating disease with a high mortality rate. Gene therapy with anti-microRNA inhibitors has been suggested as a new modality for treatment of glioblastoma. In this study, glioblastoma-targeted extracellular-vesicles (EV...
Preparation of cationic liposomes loaded with Sirtuin 6 plasmid for the treatment of arthritis in rats [0.03%]
用于治疗大鼠关节炎的Sirtuin 6质粒载有阳离子脂质体的制备
Xiaolong Yu,Yanjia Lu,Ruixiao Song et al.
Xiaolong Yu et al.
Arthritis, ormalizedn by chronic joint inflammation, is increasingly prevalent due to global ageing, placing significant pressure on healthcare systems. Recent studies have identified Sirtuin 6 (Sirt6) as a promising therapeutic target for ...
Harnessing Nanotechnology for Enhanced Wound Healing: Integrating Polymeric Nanoparticles with Rosuvastatin for Targeted Therapy [0.03%]
纳米技术在伤口愈合中的应用：聚乙烯 nanoparticles与罗苏伐他汀的靶向治疗集成
Omnia M Sarhan,Mostafa I Gebril,Hend H Mohamed et al.
Omnia M Sarhan et al.
Purpose: This study investigates the development and evaluation of rosuvastatin-loaded polymeric nanoparticles as a targeted wound-healing therapy. By integrating rosuvastatin into nanocarriers, the work aims to overcome ...
A dual-sensitive nanoparticle-mediated synergistic therapy strategy involving photodynamic therapy, chemotherapy and ICD stimuli to treat breast cancer [0.03%]
一种用于治疗乳腺癌的结合光动力疗法、化疗和ICD刺激的协同纳米粒子介导策略
Yuan Li,Haolong Qi,Yingjie Geng et al.
Yuan Li et al.
The combination therapy strategy exerts a significant anti-tumour effect by synergistically eliminating tumour cells through the use of two or more treatments. Nanomedicine delivery systems are widely employed in cancer therapy owing to the...
Research progress of microneedle drug delivery system in the treatment of autoimmune diseases [0.03%]
微针递药系统治疗自身免疫性疾病的研究进展
Tiantian Wu,Xiaowei Li,Wei Wei et al.
Tiantian Wu et al.
Autoimmune diseases represent a heterogeneous group of disorders characterized by immune system dysregulation, wherein aberrant responses to self-antigens result in cellular and tissue damage. According to statistics, there are over 80 diff...
Targeting Lipopolysaccharides in Gram-negative Sepsis: Therapeutic Advances and Challenges [0.03%]
革内氏菌耐药败血症治疗的新靶点——脂多糖：进展与挑战
Oluwakorede Akele,Freeha Rana,Sudeep Acharya et al.
Oluwakorede Akele et al.
Gram-negative bacterial sepsis remains a major global health threat, exacerbated by rising antimicrobial resistance and limited efficacy of current therapies. Central to its pathogenesis is lipopolysaccharide (LPS), a potent endotoxin that ...