Targeting glioblastoma with hybrid H3R antagonists with piperidinylpropoxy and trimethoxychalcone motifs results in broad oncosuppressive effects [0.03%]
兼具哌啶基丙氧基和三甲氧基查尔康基模序的组胺H3受体拮抗剂对胶质母细胞瘤具有广谱的抑瘤效果
Waldemar Wagner,Anna Stasiak,Dorota Łażewska et al.
Waldemar Wagner et al.
Among the many emerging strategies in precision medicine, surface receptor-directed drugs offer a promising pathway for the targeted and effective delivery of a cure. Histamine receptor (H3R) antagonists have been demonstrated to target and...
Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: A novel paradigm for preventing UVB-induced skin photoaging [0.03%]
通过抗坏血酸棕榈酸酯/透明质酸增强型limosome递送 fisetin：预防UVB引起的皮肤光老化的新理念
Asmaa H Elwan,Soha M El-Masry,Doaa A Habib et al.
Asmaa H Elwan et al.
This study investigates the topical delivery of Fisetin (FIS) to counteract UVB-induced skin photoaging. Due to FIS's poor solubility and high lipophilicity, it was encapsulated in D-limonene-modified phospholipid carriers, limosomes (LIMOs...
Development of an Effective Drug Carrier for Targeted Therapy in Lung Adenocarcinoma Using ROS-responsive Micelles [0.03%]
用于肺癌靶向治疗的ROS响应型胶束药物载体的研究与发展
Yuan Liu,Lu Zhang,Liang Kong et al.
Yuan Liu et al.
Lung cancer is the malignant tumor with the highest growing morbidity and mortality rates worldwide. Lung adenocarcinoma is the most prevalent type of non-small cell lung cancer (NSCLC). It is highly malignant and may lead to distant metast...
Improving the Therapeutic Efficacy and Bioavailability of Carvedilol for Control of Diabetes-Associated Heart Failure: In Vitro and In Vivo Characterization [0.03%]
卡维地洛治疗糖尿病相关性心力衰竭疗效和生物利用度的改善：体内外特征研究
Tamer Mohamed Mahmoud,Mohammed Ayad Alboreadi,Amr Gamal Fouad et al.
Tamer Mohamed Mahmoud et al.
Carvedilol (CRD) is an oral beta-adrenergic antagonist approved for treating heart failure (HF). However, due to its short half-life and poor solubility, CRD has limited bioavailability and effectiveness. This study aimed to develop a nasal...
Effectiveness of glucosamine hydrochloride and eperisone with exercise therapy on inflammatory factors and knee joint function in patients with knee osteoarthritis [0.03%]
硫酸氨基葡萄糖联合依匹斯亭配合运动疗法对膝骨关节炎患者炎症因子及膝关节功能的影响效果
Jun Ruan,Xuanying Li
Jun Ruan
Objective: This study aimed to unveil the effect of glucosamine hydrochloride (GAH) and eperisone combined with exercise therapy on inflammatory markers and knee joint function in patients with knee osteoarthritis (KOA). ...
Design and in vivo evaluation of a multi-epitope vaccine that suppresses tumor growth in a murine colorectal cancer model [0.03%]
设计并体内评价一种在小鼠结直肠癌模型中抑制肿瘤生长的多表位疫苗
Alisa Khodadadi,Saeid Afshar,Rezvan Najafi et al.
Alisa Khodadadi et al.
Harnessing the immune system through cancer vaccines offers a promising strategy to overcome tumor heterogeneity, which remains one of the most significant challenges in achieving effective treatment for colorectal cancer (CRC). In this stu...
DNAJA1 as a Modulator of CD8+ T-Cell Function and Prognosis in Lung Cancer: Implications for Immune Regulation and Therapeutic Targeting [0.03%]
DNAJA1在肺癌中调节CD8+t细胞功能和预后的作用及其免疫调控和治疗靶点的潜在意义
Shengkai Yang,Lian Liu,Yubiao Guo et al.
Shengkai Yang et al.
In lung adenocarcinoma (LUAD), dysfunctional CD8+ T-cells and an immunosuppressive tumour microenvironment (TME) are major barriers to effective immunotherapy, yet the molecular regulators coordinating T cell exhaustion and macrophage polar...
Formulation and optimization of NEs for enhancing topical delivery of methotrexate in CFA induced arthritis rat model [0.03%]
优化甲氨蝶呤纳米乳以改善CFA诱导的关节炎大鼠模型皮下给药效果
Amruta Parmar,Brijesh S
Amruta Parmar
Methotrexate (MTX) is widely used in treating cancers and inflammatory conditions like psoriasis and rheumatoid arthritis (RA), however is associated with side effects. NEs offer enhanced stability, protection, and improved permeation via v...
Improving the Bioavailability and Therapeutic Efficacy of Valsartan for the Control of Cardiotoxicity-Associated Breast Cancer [0.03%]
valsartan在控制心毒性相关乳腺癌中的提高生物利用度和治疗疗效
Mary Eskander Attia,Fatma I Abo El-Ela,Saad M Wali et al.
Mary Eskander Attia et al.
Cardiotoxicity remains the most severe side effect of breast cancer (BC) treatments. Valsartan, an angiotensin-II receptor blocker, has antioxidant properties that can mitigate cardiotoxicity-associated BC (CABC). However, valsartan's limit...
SUPRADES: Unlocking the Versatility of Cyclodextrin-Based Deep Eutectic Solvents [0.03%]
SUPRADES：解锁基于环糊精的深共熔溶剂的多功能性
Nikita V Pawar,Maheshkumar R Borkar
Nikita V Pawar
Green and sustainable technologies have emerged in recent years as a result of increased public awareness of the damaging effects that chemicals have on the environment. To replace ionic liquids (ILs) and traditional organic solvents, deep ...