Liposomal nano-drugs based on amphipathic weak acid steroid prodrugs for treatment of inflammatory diseases [0.03%]
两性弱酸甾体前药基纳米脂质体制备及其抗炎机理研究
Keren Turjeman,Yechezkel Barenholz
Keren Turjeman
Background: Steroids are the most efficacious anti-inflammatory agents. However, their toxicities and side-effects compromise their clinical application. Various strategies and major efforts were dedicated for formulating...
SET protein overexpression contributes to paclitaxel resistance in MCF-7/S cells through PI3K/Akt pathway [0.03%]
SET蛋白过表达通过PI3K/Akt途径促进MCF-7/S细胞紫杉醇耐药性的发展
Weipeng Zhang,Xiaowei Zheng,Ti Meng et al.
Weipeng Zhang et al.
Patient SE translation (SET) is a carcinogen in facilitating cellular growth and proliferation, and promoting tumorigenesis and metastasis. The present study was to investigate the resistance mechanisms associated with SET in paclitaxel-ind...
Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice [0.03%]
内皮素受体ETB通过调节氧化应激和细胞因子产生调控小鼠超氧阴离子诱导的炎症和疼痛
Victor Fattori,Karla G G Serafim,Ana C Zarpelon et al.
Victor Fattori et al.
The present study investigated whether endothelin-1 acts via ETA or ETB receptors to mediate superoxide anion-induced pain and inflammation. Mice were treated with clazosentan (ETA receptor antagonist) or BQ-788 (ETB receptor antagonist) pr...
Recent trends in the transdermal delivery of therapeutic agents used for the management of neurodegenerative diseases [0.03%]
治疗神经退行性疾病的药物经皮递送的近期趋势
Kevin Ita
Kevin Ita
With the increasing proportion of the global geriatric population, it becomes obvious that neurodegenerative diseases will become more widespread. From an epidemiological standpoint, it is necessary to develop new therapeutic agents for the...
Intelligent polymeric micelles: development and application as drug delivery for docetaxel [0.03%]
智能聚合物胶束的开发及载多西他赛药物传输方面的应用研究
Yimu Li,Hui Zhang,Guang-Xi Zhai
Yimu Li
Recent years, docetaxel (DTX)-loaded intelligent polymeric micelles have been regarded as a promising vehicle for DTX for the reason that compared with conventional DTX-loaded micelles, DTX-loaded intelligent micelles not only preserve the ...
Curcumin synergistically increases effects of β-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3-dependent and STAT3-independent pathways [0.03%]
姜黄素通过STAT3依赖和非依赖通路上调GRIM-19增强β-干扰素及视黄酸对乳腺癌的抑制作用
Min Ren,Ying Wang,Xiaodong Wu et al.
Min Ren et al.
Objective: The study aimed to investigate the effects of combination treatment of curcumin and β-interferon (IFN-β)/retinoic acid (RA) on breast cancer cells, including cell viability, apoptosis and migration, and to de...
Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines [0.03%]
近期基于石墨烯氧化物的多功能纳米药物癌症靶向治疗研究进展
Nazanin Rahmanian,Morteza Eskandani,Jaleh Barar et al.
Nazanin Rahmanian et al.
Rapid progresses in nanotechnology fields have led us to use a number of advanced nanomaterials (NMs) for engineering smart multifunctional nanoparticles (NPs)/nanosystems (NSs) for targeted diagnosis and therapy of various diseases includi...
iRGD-mediated core-shell nanoparticles loading carmustine and O6-benzylguanine for glioma therapy [0.03%]
用于胶质瘤治疗的iRGD介导载卡莫司汀和O6-苄基鸟嘌呤核壳型纳米粒子
Chang Liu,Sen Yao,Xuqian Li et al.
Chang Liu et al.
iRGD (internalizing RGD) with high affinity to αν integrins was reported to enhance tumor penetrability by binding to neuropilin-1 (NRP-1). Based on our previous study, chitosan surface-modified poly (lactide-co-glycolides) nanoparticles ...