Targeted colon cancer therapy using lapatinib-encapsulated chitosan nanoparticles conjugated with lactoferrin and melatonin with integrated in silico in vitro and in vivo evaluation [0.03%]
结合乳铁蛋白和褪黑素的壳聚糖纳米粒包载拉帕替尼的结肠癌靶向治疗：体外、体内及基于计算机计算的综合评价
Upasana,Sankha Bhattacharya,Vishal Beldar et al.
Upasana et al.
Colorectal cancer is major cause of mortality, necessitating improved treatments. Lapatinib-loaded chitosan nanoparticles conjugated with lactoferrin and melatonin (LAP-CS-LF-MLT-NPs) developed using ionic gelation and carbodiimide coupling...
Carbon Nanodots in Breast Cancer Management: Emerging Tools for Diagnosis and Therapy [0.03%]
乳腺癌管理中的碳纳米点：诊断和治疗的新工具
Vrutti Parmar,Krina Patel,Sachin Sharma et al.
Vrutti Parmar et al.
Breast cancer is still a major global health issue and calls for innovative approaches for both early detection and effective treatment. Because of their distinct optical characteristics, biocompatibility, and ease of surface functionalizat...
In vitro and in vivo evaluation of the therapeutic efficacy of in-situ pH-sensitive carvedilol-loaded novasomes as a therapy for diabetes-associated coronary artery disease [0.03%]
体外和体内评估新型卡维地洛负载囊泡作为糖尿病相关冠状动脉疾病治疗的疗效研究
Amr Gamal Fouad,Amany Belal,Alaa Ismail et al.
Amr Gamal Fouad et al.
Coronary artery disease (CAD) is a condition in which the blood vessels that supply oxygen to the heart become narrowed. Hyperglycemia contributes to vascular dysfunction in CAD by causing damage to endothelial cells and smooth muscle in th...
In Vitro and In Vivo Assessment of the Bioavailability and Efficacy of Carvedilol-loaded Novasomes as a Therapy for Diabetes Mellitus-associated Ischemic Stroke [0.03%]
卡维地洛诺伐索姆作为糖尿病相关缺血性卒中治疗的体内外生物利用度及疗效评估
Amr Gamal Fouad,Amany Belal,Alaa Ismail et al.
Amr Gamal Fouad et al.
Ischemic stroke (IS) occurs when there is a deprivation of oxygen and nutrients in brain tissue. Diabetes mellitus (DM) is recognized as a possible factor contributing to this illness. Carvedilol exhibits anti-stroke effects; however, its i...
Astragaloside-Soluplus/TPGS/Glycyrrhizic acid ammonium Salt Mixed Micelles: Preparation and pharmacodynamic evaluation [0.03%]
黄茋皂苷-Soluplus/TPGS/甘草酸铵混合胶束的制备及其药效学评价
Hong Chen,Michael Adu-Frimpong,Lili Yuan et al.
Hong Chen et al.
Astragaloside, a natural flavonol glycoside isolated from plants, exhibits significant tumor-suppressive activity. However, its low solubility and poor bioavailability have hindered its practical application. To improve its bioavailability ...
Advancements on Nanoparticles-based Approaches for the Management of Rheumatoid Arthritis (RA): Molecular Mechanism, Toxicity, and Clinical Perspectives [0.03%]
基于纳米颗粒的治疗类风湿性关节炎（RA）的方法进展：分子机制、毒性及临床视角
Sabya Sachi Das,Md Sadique Hussain,Srushti Tambe et al.
Sabya Sachi Das et al.
The nanoparticles (NPs) exhibited significant pharmacological potential due to their inherent physicochemical and biological characteristics in biomedical and tissue engineering applications. Rheumatoid arthritis (RA) is a chronic, inflamma...
Targeted Nanodrug Delivery Strategies for Precision Chemotherapy in Prostate Cancer [0.03%]
前列腺癌的精准化疗纳米药物输送策略
Tianfeng Bi,Xiaoyu Wang,Lili Chen et al.
Tianfeng Bi et al.
Prostate cancer is one of the most common malignancies globally, with chemotherapy remaining a cornerstone treatment for advanced and metastatic cases. However, traditional chemotherapy is limited by poor targeting, low bioavailability, and...
Thermosensitive transniosomal in situ gel of hesperetin for intranasal administration: Novel approach for Parkinson's therapy [0.03%]
用于鼻内给药的橙皮苷热敏性经鼻载药脂质体凝胶剂：帕金森病治疗的新方法
Nazreen Tabassum,Niha Sultana,Asad Ali et al.
Nazreen Tabassum et al.
The present study aims to formulate and evaluate a thermosensitive transniosomal in situ gel of hesperetin (HST-TN) for intranasal delivery to improve its therapeutic efficacy in Parkinson's disease management. HST-TN was prepared via thin ...
Nanotransethosomal co-drug delivery system of diclofenac sodium and rosmarinic acid against rheumatoid arthritis: Design, formulation, characterization and pre-clinical studies [0.03%]
用于治疗类风湿关节炎的氯诺昔康和鼠李酸纳米囊泡共药物递送系统：设计、制剂、表征及临床前研究
Akanksha,Neeraj Kumar,Asad Ali et al.
Akanksha et al.
Rosmarinic acid, an ester between caffeic acid and 3,4-dihydroxyphenyllactic acid, is distributed in broad distribution throughout plants within the Boraginaceae family and Nepetoideae subfamily of Lamiaceae. It has been identified with its...
Recent advances in chitosan-based nanomaterials and conjugates for active and passive targeting of cancer cells [0.03%]
基于壳聚糖的纳米材料及缀合物在主动和被动靶向肿瘤细胞领域的最新研究进展
Himali Horo,Jiwanjot Sharma
Himali Horo
Chitosan-based materials have gained significant attention in drug delivery owing to their exceptional properties, including biocompatibility, biodegradability, mucoadhesiveness, and tunable physicochemical characteristics. Their structural...