Yujie Li,Xinyue Liu,Xueli Liu et al.
Yujie Li et al.
Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the wel...
Impact of methionine restriction on muscle aerobic metabolism and hypertrophy in young and old mice on an obesogenic diet [0.03%]
甲硫氨酸限制对肥胖饮食年轻和老年小鼠肌肉有氧代谢和增生的影响
Anandini Swaminathan,Leonardo Cesanelli,Tomas Venckunas et al.
Anandini Swaminathan et al.
Methionine restriction (MR) reduces inflammation and increases longevity. We studied the effects of MR (0.17% kCal methionine, 10% kCal fat) and MR + high-fat diet (HFD) (0.17% methionine, 45% kCal fat) and overload-induced hypertrophy on i...
miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy [0.03%]
microRNA-146a通过抑制血管内皮生长因子表达及减轻炎症反应治疗糖尿病视网膜病变的作用研究
Shichao Sun,Fujun Wang,Yao Sun et al.
Shichao Sun et al.
This study was designed to explore the role of miR-146a in diabetic retinopathy (DR). 30 healthy control (HC), 50 patients with type 2 diabetes mellitus, and 48 DR patients were enrolled. Blood was collected and levels of miR-146a expressio...
An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications [0.03%]
血管内皮生长因子（VEGF）在伤口愈合中的动态作用及其当前临床应用评估
Aakansha Giri Goswami,Somprakas Basu,Farhanul Huda et al.
Aakansha Giri Goswami et al.
Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endo...
The effects of CHF6467, a new mutated form of NGF, on cell models of human glioblastoma. A comparison with wild-type NGF [0.03%]
一种新的NGF突变体CHF6467对人类胶质母细胞瘤细胞模型的作用效果与野生型NGF的比较研究
Lucia Lisi,Gabriella Maria Pia Ciotti,Marta Chiavari et al.
Lucia Lisi et al.
CHF6467 is a mutated form of human recombinant nerve growth factor (NGF). The mutation selectively disrupts the binding of NGF to its p75NTR receptor while maintaining the affinity toward TrkA receptor. Because of such different profile of ...
Kah Man Lai,Wai Leng Lee
Kah Man Lai
Viruses are intracellular pathogen that exploit host cellular machinery for their propagation. Extensive research on virus-host interaction have shed light on an alternative antiviral strategy that targets host cell factors. Epidermal growt...
Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway [0.03%]
淫羊藿黄酮抑制Notch2/Hes-1信号通路治疗肾纤维化作用及机制研究
Qiaoqi Zhang,Lei Xie,Lin Jiang et al.
Qiaoqi Zhang et al.
Chinese herbs were widely proposed as a novel approach for renal fibrosis. Icariin has been reported to be involved in a variety of diseases. Unilateral ureteral obstruction (UUO) is a popular experimental model of renal injury, which is of...
Systematic training in master swimmer athletes increases serum insulin growth factor-1 and decreases myostatin and irisin levels [0.03%]
系统训练对名游泳运动员生长素和肌生成抑制蛋白及irisin的影响
V Curiel-Cervantes,J C Solis-Sainz,M Camacho-Barrón et al.
V Curiel-Cervantes et al.
During ageing, anabolic status is essential to prevent the decrease in quantity and quality of skeletal muscle mass (SMM). Exercise modulates endocrine markers of muscle status. We studied the differences of endocrine markers for muscle sta...
The pheromone affects reproductive physiology and behavior by regulating hormone in juvenile mice [0.03%]
信息素通过调节幼年小鼠体内激素影响其生殖生理和行为响应
Bing Hu,Zhongxiang Mo,Jianlin Jiang et al.
Bing Hu et al.
Pheromones could promote hormone secretions and regulate sexual behavior. It was unclear whether multiparous pheromone could induce variations in puberty. The aim was to ascertain whether pheromone in urine of multiparous females induced ce...
Paul T Williams
Paul T Williams
Background: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution. ...