Embryonic growth retardation and altered expression of IGF-II is reciprocal induced by phytocompounds during early gestation in mice [0.03%]
植物化合物通过早期妊娠在小鼠中互为因果地诱导胚胎生长迟缓和IGF-II表达改变
Khamhee Wangsa,Krishnakshi Misra,Upasa Gowala et al.
Khamhee Wangsa et al.
Methanolic crude extract of Scoparia dulcis (CESD) was orally administered to female mice during the early gestation (day 4-day 8) at a dose of 500 mg/kg/day. It induces embryo resorption and morphological changes of fetal maternal tissue. ...
High mobility group box 1 and Dickkopf-related protein 1 as biomarkers of glucose toxicity, atherogenicity, and lower β cell function in patients with type 2 diabetes mellitus [0.03%]
高迁移率族蛋白箱1和Dickkopf相关蛋白1作为2型糖尿病患者葡萄糖毒性、致动脉粥样硬化性以及更低β细胞功能的生物标志物
Hussein Kadhem Al-Hakeim,Qasim Jasim Al-Kaabi,Michael Maes
Hussein Kadhem Al-Hakeim
Type 2 diabetes mellitus (T2DM) is associated with increased atherogenicity and inflammatory responses, which may be related to high mobility group box 1 (HMGB1) and Dickkopf-related protein 1 (DKK1). The role of HMGB1 and DKK1 in T2DM is e...
Increased circulating TGF-β1 is associated with impairment in NK cell effector functions in metastatic melanoma patients [0.03%]
转化生长因子-β1与黑色素瘤患者NK细胞效应功能障碍相关性研究
Katarina Mirjačić Martinović,Ana Vuletić,Emina Mališić et al.
Katarina Mirjačić Martinović et al.
Transforming growth factor beta (TGF-β) plays a complex role in carcinogenesis. In 30 melanoma patients and 20 healthy controls (HC) we analysed functional and phenotypic characteristics of NK cells by Flow cytometry, gene expression of TG...
Effects of dual-gene modification on biological characteristics of vascular endothelial cells and their significance as reserving cells for chronic wound repair [0.03%]
双基因修饰对血管内皮细胞生物学特性的影响及在慢性伤口修复中作为储备细胞的意义研究
Lingli Guo,Baohua Wei,Feng Pan et al.
Lingli Guo et al.
bFGF is a commonly used and reliable factor for improving chronic wound healing, and hSulf-1 expression is abundant in surrounding cells of chronic wound tissue and vascular endothelial cells, which can reverse the effect of bFGF and inhibi...
MiR-200c regulates invasion, proliferation and EMT of anaplastic thyroid cancer cells by targeting parathyroid hormone like hormone [0.03%]
miR-200c通过靶向甲状旁腺激素类似物调节间变性甲状腺癌细胞的侵袭、增殖和上皮间质转化
Yan Zhang,Yuanyuan Duan,Chenguang Wu et al.
Yan Zhang et al.
This study aimed to explore the specific effect of miR-200c in anaplastic thyroid cancer (ATC). Hth74 and ARO cell lines were used. Proliferation, invasion, and colony formation activities of Hth74 and ARO cell lines affected by miR-200c we...
Platelet lysate and tendon healing: comparative analysis of autologous frozen-thawed PRP and ketorolac tromethamine in the treatment of patients with rotator cuff tendinopathy [0.03%]
血小板溶解物与肌腱愈合：自体冻融富血小板血浆与酮咯酸氨化钠治疗肩袖肌腱病患者的比较分析研究
Raha Markazi,Mohammad Sadegh Soltani-Zangbar,Majid Zamani et al.
Raha Markazi et al.
Platelet-rich blood derivatives are being nowadays increasingly used in the treatment of tendon-related pathologies as a rich source of growth factors. We sought to ascertain if local application of platelet lysate (PL) to augment rotator c...
Randomized Controlled Trial
Growth factors (Chur, Switzerland). 2022 Nov;40(5-6):163-174. DOI:10.1080/08977194.2022.2093198 2022
Halofuginone inhibits cell proliferation and AKT/mTORC1 signaling in uterine leiomyoma cells [0.03%]
卤满酮通过抑制子宫平滑肌瘤细胞的增殖和Akt/mTORC1信号传导发挥作用
Jing Lin,Xiaochun Wu
Jing Lin
The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL ELT3 cells were measured. Flow cytometry was used to assess ...
Effects of penehyclidine hydrochloride on myocardial ischaemia-reperfusion injury in rats by inhibiting TLR4/MyD88/NF-κB pathway via miR-199a-3p [0.03%]
氯化苯乙希丁通过miR-199a-3p抑制TLR4/MyD88/NF-κB信号通路减轻大鼠心肌缺血再灌注损伤的效果研究
Ling Qiang Bai,Bin Zhe Wang,Qi Wei Liu et al.
Ling Qiang Bai et al.
This study was to probe the role of penehyclidine hydrochloride (PHC) mediating the impact of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signalling pathway on myocardial ischaemia-r...
The expression of BMP, integrin, ZEB2 in ovarian high-grade serous carcinoma in relation with lymph node metastasis [0.03%]
BMP、整合素、ZEB2在卵巢高级别浆液性癌淋巴结转移中的表达关系研究
Elham Bahador Zırh,Elif Taşar Kapaklı,Anıl Dolgun et al.
Elham Bahador Zırh et al.
Ovarian cancer (OC) is clinically important because it is diagnosed late and has metastasis when it is diagnosed. Mortality risk increases 2.75 times in the presence of lymph node (LN) metastasis. During metastasis, many molecules including...
Oliver Cucanic,Rae H Farnsworth,Steven A Stacker
Oliver Cucanic
Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tum...