A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs [0.03%]
添加剂在神经组织工程中的作用综述：生长因子、维生素和药物
Mehrsa Nasiri,Javad Esmaeili,Amir Tebyani et al.
Mehrsa Nasiri et al.
Notably the integration of additives such as growth factors, vitamins, and drugs with scaffolds promoted nerve tissue engineering. This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An a...
Dynamics of transforming growth factor β signaling and therapeutic efficacy [0.03%]
转化生长因子β信号转导的动态变化及其疗效分析
Siqi Wu,Rodney Brian Luwor,Hong-Jian Zhu
Siqi Wu
Transforming growth factor β (TGFβ) is a multifunctional cytokine, and its signalling responses are exerted via integrated intracellular pathways and complex regulatory mechanisms. Due to its high potency, TGFβ signalling is tightly cont...
Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition [0.03%]
TP63转录因子通过上调KRT17表达诱导上皮间质转化从而促进甲状腺癌恶性进展
Fanbo Meng,Liting Dai
Fanbo Meng
Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene inte...
Characterisation of mesenchymal stem cells conditioned media obtained at different conditioning times: their effect on glial cells in in vitro scratch model [0.03%]
不同时间条件下培养的间充质干细胞条件培养基的表征及其对体外伤口愈合模型中胶质细胞的作用
Eva Székiová,Zuzana Michalová,Juraj Blaško et al.
Eva Székiová et al.
In this study, the bone marrow mesenchymal stem cells conditioned media (BMMSC-CM) obtained by conditioning for 24(CM24), 48(CM48) and 72(CM72) hours was characterised. In vitro, the impact of BMMSC-CM on the astrocyte migratory response an...
HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia [0.03%]
HIVEP3作为潜在的预后因素促进急性髓系白血病的发展
Yanfei Tang,Guangtao Xu,Bo Hu et al.
Yanfei Tang et al.
Acute myeloid leukemia (AML) is a common malignancy worldwide. Human immune deficiency virus type 1 enhancer-binding protein 3 (HIVEP3) was verified to play a vital role in types of cancers. However, the functional role of HIVEP3 in AML was...
Successful production of human epidermal growth factor in tobacco chloroplasts in a biologically active conformation [0.03%]
烟草叶绿体中人类表皮生长因子的生物活性构象成功生产
Yunpeng Wang,Jieying Fan,Niaz Ahmad et al.
Yunpeng Wang et al.
Human epidermal growth factor (hEGF) is an important therapeutic compound with multiple applications particularly in pharmaceutical industry. Human EGF has already been expressed in different expression systems, however, the production of h...
Effects of propofol on IGF-1 activity and cell behaviour in the GES 1 mucosal cell model [0.03%]
丙泊酚对GES 1粘膜细胞模型中IGF-1活性和细胞行为的影响
Chai Hua,Peng Wenyong,Zhu Zhongquan et al.
Chai Hua et al.
Propofol is an important and widely used anaesthetic drug in the clinic. Many works have shown that propofol has important biological functions except as an anaesthetic. In the current study, we mainly explored the effect of propofol on the...
Retinoic acid signaling is critical for generation of pancreatic progenitors from human embryonic stem cells [0.03%]
视黄酸信号在产生胰腺祖细胞中起关键作用
Niloufer P Dumasia,Aparna P Khanna,Prasad S Pethe
Niloufer P Dumasia
Retinoic acid (RA) is essential for gut endoderm development and has been extensively used for in vitro pancreatic differentiation from human pluripotent stem cells. However, the gene regulatory network triggered by RA signaling remains poo...
The polymethoxylated flavone hexamethylquercetagetin suppresses NF-κB signaling and inhibits cell survival in cervical carcinoma [0.03%]
多甲基黄酮六甲基补骨脂素抑制宫颈癌中NF-κB信号传导及细胞生存力
Yanan Sun,Nan Li,Yuru Cai et al.
Yanan Sun et al.
Nuclear factor-κB (NF-κB) contributes to the development and progression of cervical carcinoma. To construct a xenograft model, Ca Ski cells were subcutaneously inoculated into BALB/c nude mice. The relative protein expression of NF-κB p...
Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis [0.03%]
小檗胺通过微藻素-299-3P/PGAM1轴诱导肝癌细胞凋亡并抑制EMT和肿瘤干细胞特性
BaoLin Wang,HuiHai Wang,Qin Zhao et al.
BaoLin Wang et al.
This study explored the impacts of matrine on hepatocellular carcinoma (HCC) cell growth, metastasis, epithelial-mesenchymal transition (EMT), and stemness through regulating the microRNA (miR)-299-3p/phosphoglycerate mutase 1 (PGAM1) axis....