Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke [0.03%]
基于网络药理学和分子对接的当归补血汤治疗缺血性卒中的研究
Jinling Zhang,Ruiqing Li,Yang Yu et al.
Jinling Zhang et al.
Danggui blood-supplementing decoction (DBsD) is an herbal preparation treating several diseases including stroke. The present study sought to investigate the potential mechanism of DBsD in ischaemic stroke (IS) using network pharmacology, m...
Andrija Jurina,Dino Kasumović,Valentina Delimar et al.
Andrija Jurina et al.
Fibroblast growth factor 23 (FGF23) has been casually linked to numerous hypophosphatemic bone diseases, however connection with bone loss or fragility fractures is still a matter of debate. The purpose of this review is to explore and summ...
Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway [0.03%]
IGFBP2敲低通过STAT3信号通路缓解重度肺炎大鼠肺纤维化和炎症反应
Yuyu Wang,Jianjiang Huang,Fang Zhang et al.
Yuyu Wang et al.
Objective: To observe the mechanism of IGFBP2 knock-down in improving lung fibrosis and inflammation through STAT3 pathway in rats with severe pneumonia. ...
Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans [0.03%]
转化生长因子-β在支气管肺泡病气道重建中的作用
Ziwei Wang
Ziwei Wang
Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during airway remodelling, where it plays an import...
Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression [0.03%]
转录因子ETV1诱导的长链非编码RNA MAFG-AS1通过募集IGF2BP2稳定ETV1表达来促进胰腺癌细胞迁移、侵袭和上皮间质转化
Hanqin Weng,Weijian Feng,Fengling Li et al.
Hanqin Weng et al.
We investigated the mechanism of ETS-translocation variant 1 (ETV1)/lncRNA-MAFG-AS1 in pancreatic cancer (PC). MAFG-AS1 and ETV1 levels in PC cell lines and HPNE cells were determined using reverse transcription quantitative polymerase chai...
Microfracture technique combined with mesenchymal stem cells inducer represses miR-708-5p to target special at-rich sequence-binding protein 2 to drive cartilage repair and regeneration in rabbit knee osteoarthritis [0.03%]
微骨折技术联合间充质干细胞诱导剂通过抑制miR-708-5p靶向特异性A/T丰富序列结合蛋白2促进兔膝骨关节炎软骨修复和再生
YongChao Wang,Qin Su,HaiRong Tang et al.
YongChao Wang et al.
Knee osteoarthritis (KOA) is a degenerative joint illness which leads to knee pain and functional limitation. In this study, we combined microfracture surgery with kartogenin (KGN), a small bioactive molecule used to promote the differentia...
Effects of hepatocyte growth factor-transfected mesenchymal stem cell transplantation in canine injured vocal folds [0.03%]
肝细胞生长因子转染间充质干细胞移植对犬声带损伤的疗效研究
Xingqiao Xie,Xumao Li,Xinsheng Lin et al.
Xingqiao Xie et al.
This study aimed to assess the efficacy of hepatocyte growth factor (HGF)-transfected adipose-derived mesenchymal stem cell (ADSC) transplantation in the injured vocal folds (VFs) of canines. A lentiviral vector encoding HGF was successfull...
Production of a biosimilar version of aflibercept to improve VEGF blocker cytotoxicity on endothelial cells [0.03%]
生产 aflibercept 生物仿制药以提高 VEGF 抑制剂对内皮细胞的细胞毒性
Amin Ramezani,Mohammadrasul Zareinejad,Elham Mahmoudi Maymand et al.
Amin Ramezani et al.
This project aimed to produce a biosimilar version of aflibercept (AFL) and evaluate the effect of the co-treatment of AFL with other vascular endothelial growth factor (VEGF) blocker drugs. For this purpose, the optimized gene was inserted...
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer [0.03%]
技术进步定义了正常和原发及转移性结直肠癌的信号通路转变
Robert G Ramsay,Vicki Whitehall,Michael P Flood
Robert G Ramsay
Adoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of ge...
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis [0.03%]
自体富血小板血浆和血小板溶酶治疗膝关节骨关节炎的比较研究
Sareh Hosseini,Mohammad Sadegh Soltani-Zangbar,Majid Zamani et al.
Sareh Hosseini et al.
Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (K...