Nicotine potentiates vascular endothelial growth factor expression in balloon-injured rabbit aortas [0.03%]
尼古丁可增强血管内皮生长因子在损伤兔主动脉中的表达作用
Yao Zhen,Yin Ruixing,Bi Qi et al.
Yao Zhen et al.
Both nicotine and vascular endothelial growth factor (VEGF) have been proposed to play an important role in the development and progression of atherosclerosis. In vitro and ex vivo studies have demonstrated that nicotine significantly stimu...
Sustained release and activation of the growth factor basic fibroblast growth factor from loaded scaffolds in heart valve tissue engineering [0.03%]
负载生长因子的控释及在心脏瓣膜组织工程中的活性研究
Pamela Somers,Kishan Narine,Filip De Somer et al.
Pamela Somers et al.
Objectives: Loading of biological matrices offers an opportunity to induce specific cell behaviour. We previously reported the use of growth factors to promote cell invasion and proliferation in tissue valve engineering. ...
TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines [0.03%]
转化生长因子-β对人类结直肠癌细胞系增殖和悬滴凋亡具有悖论性和依赖背景环境的影响
Nina M Muñoz,Ji Yeon Baek,William M Grady
Nina M Muñoz
Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. It is unclear what determines when TGF-beta and its signaling pathway act predominant...
Effects induced by BMPS in cultures of human articular chondrocytes: comparative studies [0.03%]
bmps对人关节软骨细胞培养的影响及机制比较研究
Susan Chubinskaya,Diane Segalite,Dmitriy Pikovsky et al.
Susan Chubinskaya et al.
We compared anabolic and anti-catabolic activities of selected bone morphogenetic proteins (BMP-2, -4, -6, and -7) and cartilage-derived morphogenetic proteins (CDMP-1 and -2) in human normal adult articular chondrocytes. Ankle chondrocytes...
Comparative Study
Growth factors (Chur, Switzerland). 2008 Oct;26(5):275-83. DOI:10.1080/08977190802291733 2008
Clinical impact of real-time evaluation of the biological activity and degradation of hepatocyte growth factor [0.03%]
实时评估肝细胞生长因子生物学活性和降解的临床影响
Fariba Nayeri,Tayeb Nayeri,Daniel Aili et al.
Fariba Nayeri et al.
Hepatocyte growth factor (HGF) is essential for injury repair. Despite high HGF levels in chronic ulcers, up-regulation of HGF receptor in ulcer tissue and decreased biological activity of HGF in ulcer secretions have been observed. With a ...
Gerard Such-Sanmartín,Jaume Bosch,Jordi Segura et al.
Gerard Such-Sanmartín et al.
Objectives: The 5 kDa N-terminal fragment of 43 amino acids of human growth hormone (GH) shows a specific and significant in-vivo insulin-like activity. This isoform can be easily obtained by solid phase synthesis methods...
OP-1 injection increases VEGF expression but not angiogenesis in a rabbit model of distraction osteogenesis [0.03%]
OP-1注射在牵张成骨兔模型中增加VEGF表达但不影响血管生成
Manuela Mandu-Hrit,Erin Seifert,Maria Kotsiopriftis et al.
Manuela Mandu-Hrit et al.
We have previously shown that a single injection of rhBMP-7 (OP-1) applied to the regenerate early during distraction accelerates bone consolidation in a rabbit model of distraction osteogenesis. In the present study, we hypothesised that t...
Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells [0.03%]
腺病毒介导生长分化因子-5的表达促进脂肪来源干细胞软骨生成诱导及基因治疗效果
Gang Feng,Yuqing Wan,Gary Balian et al.
Gang Feng et al.
The repair of articular cartilage injuries is impeded by the avascular and non-innervated nature of cartilage. Transplantation of autologous chondrocytes has a limited ability to augment the repair process due to the highly differentiated s...
Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165 [0.03%]
不同的信号途径赋予VEGF121和VEGF165不同的血管反应
Yan Zhang,Minao Furumura,Eishin Morita
Yan Zhang
Vascular endothelial growth factor (VEGF) is a pleiotropic factor that regulates embryonal vasculogenesis, tumor angiogenesis and vascular permeability. Among eight differential isoforms, VEGF 121 mainly regulates vascular permeability, whi...
Treatment with granulocyte colony stimulating factor is associated with improvement in endothelial function [0.03%]
粒系集落刺激因子治疗与内皮功能改善有关
Ignatios Ikonomidis,Christos Papadimitriou,Georgia Vamvakou et al.
Ignatios Ikonomidis et al.
Primary objective: Granulocyte-colony stimulating factor (G-CSF) is used for the mobilization of bone marrow and endothelial progenitor cells, though G-CSF-induced inflammation may cause endothelial dysfunction. We examin...
Randomized Controlled Trial
Growth factors (Chur, Switzerland). 2008 Jun;26(3):117-24. DOI:10.1080/08977190802090614 2008