VEGF ameliorates acute kidney injury by suppressing ferroptosis through activation of the ERK1/2-NRF2 pathway [0.03%]
VEGF通过激活ERK1/2-NRF2信号通路抑制铁死亡从而改善急性肾损伤
Xiangtian Liu,Yuqi Song,Weikun Tian et al.
Xiangtian Liu et al.
Vascular endothelial growth factor (VEGF) plays a crucial role in maintaining renal homeostasis. However, the precise impact of VEGF on ferroptosis in acute kidney injury (AKI) remains incompletely understood. This study aims to investigate...
Insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in central precocious puberty: a systematic review and meta-analysis [0.03%]
中枢性早熟的胰岛素样生长因子1和胰岛素样生长因子结合蛋白3的系统评价和meta分析
Yunyun Wu,Weili Zhao
Yunyun Wu
To identify distinct patterns of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) in girls with central precocious puberty (CPP), and to compare IGF-1 and IGFBP-3 levels in patients with CPP an...
Mesencephalic astrocyte-derived neurotrophic factor: a potential diagnostic marker in human sepsis-associated lung injury [0.03%]
.midbrain胶质细胞源性神经营养因子：人类脓毒症相关性肺损伤潜在的诊断标志物
Yan Zhou,Ni Yao,Jing-Wen Zheng et al.
Yan Zhou et al.
Systemic inflammatory response syndrome (SIRS) commonly considered as the first step in the sepsis cascade. To evaluate the diagnostic value and potential mechanism of serum MANF in sepsis-associated lung injury (SALI), 15 adult SALI patien...
An endothelial cell competition assay for determinants of the response to targeted anti-angiogenics [0.03%]
内皮细胞竞争测定法：靶向抗血管生成药物反应决定因素的测定
Michael M Halford,Michael Y He,Nancy Amin et al.
Michael M Halford et al.
ABSTRACT/SUMMARYAnti-angiogenics, inhibitors of pathological blood vessel growth, are an important class of targeted agent for the treatment of common cancers and ocular conditions. However, efficacy is compromised by the absence of biomark...
Various strategies to induce beta cell neogenesis: a comprehensive review for unravelling the potential future therapy for curing diabetes [0.03%]
β细胞新生的多种策略：全面回顾以揭示潜在治愈糖尿病的未来疗法
Anjali Patel,B Rajgopal,Manisha Jaiswal
Anjali Patel
Pancreatic endocrine cells are categorized in to 5 types (alpha, beta, delta, pancreatic polypeptide cells and epsilon), which expresses glucagon, insulin, somatostatin, pancreatic polypeptide, and ghrelin, respectively. Several studies inc...
Oxaloacetate stimulates phosphorylation of epidermal growth factor receptor in epithelial cells in vitro [0.03%]
草酰乙酸通过体外实验刺激上皮细胞中的表皮生长因子受体磷酸化
Ye Kuang,Yuxiang Zhao,Zeyu Miao et al.
Ye Kuang et al.
Oxaloacetate (OA) is a pivotal endogenous metabolite. Within our investigation, we ascertained that OA functions as an agonist for the epidermal growth factor receptor (EGFR), a key protagonist in the genesis of diverse tumours. We substant...
Expression of DDX49 in breast cancer and its mechanism regulating the proliferation and metastasis of breast cancer cells [0.03%]
DDX49在乳腺癌中的表达及其调控乳腺癌细胞增殖转移的机制研究
Yuanbin Wang,Lijun Yang,Xiangli Li et al.
Yuanbin Wang et al.
DEAD-box RNA helicase (DDX) is linked to the invasion, drug resistance, proliferation, and epithelial-mesenchymal transition of tumour cells. This study examined the potential mechanisms of DDX49 in breast cancer. The expression of DDX49 in...
Super-activated platelet lysate promotes mesenchymal stem cell proliferation, migration, and chondrogenic differentiation: an in vitro study [0.03%]
超激活的血小板裂解液促进间充质干细胞增殖、迁移和成软骨分化：体外研究
Chunxiang Liu,Tianqi Zhang,Lingqi Meng et al.
Chunxiang Liu et al.
Objective: This study aimed to investigate the effects of super-activated platelet lysate (sPL) on the proliferation, migration, and chondrogenic differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs). ...
Akt inhibition is effective against PTEN-deleted, chemoirradiation-resistant glioblastoma stem cells [0.03%]
AKT抑制作用对PTEN缺失的化疗耐药型神经胶质瘤干细胞有效
James Dimou,Giovanna D&#x;Abaco,Lucy Paradiso et al.
James Dimou et al.
Activated Akt and loss of phosphatase and tensin homolog (PTEN) tumour suppression aid chemo- and radio-resistance in glioblastoma stem cells (GSC), contributing to treatment failure in glioblastoma. In this study, sixteen GSC lines were ge...
Serum HER2 as potential prognostic biomarker in primary breast cancer patients [0.03%]
血清HER2作为原发乳腺癌患者潜在预后生物标志物的作用
Nataša Todorović-Raković,Jelena Milovanović,Marko Radulovic et al.
Nataša Todorović-Raković et al.
Tissue expressed human epidermal growth factor receptor 2 (HER2) is an established parameter of breast cancer, and it is determined in routine clinical practice by histology. This study aims to assess the prognostic value of serum HER2 prot...