Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity [0.03%]
当前关于寻找衰老和长寿遗传决定因素的趋势和方法
S S Kunizheva,V P Volobaev,M Yu Plotnikova et al.
S S Kunizheva et al.
Aging is a natural process of extinction of the body and the main aspect that determines the life expectancy for individuals who have survived to the post-reproductive period. The process of aging is accompanied by certain physiological, im...
Individual Differences in Relative Telomere Length in Mentally Healthy Subjects: The Effect of TERT Gene Polymorphism and Urban Residency [0.03%]
健康人群端粒长度的个体差异：TERT基因多态性和城市居住的影响
A V Kazantseva,Yu D Davydova,R F Enikeeva et al.
A V Kazantseva et al.
The changes in the telomere length caused by the terminal underreplication in the existing literature are related to depressive disorders. However, the use of the telomere length as a biomarker of depressive states is ambiguous, which is du...
SNP rs657152 Is Not Associated with the Level of Viral Load in COVID-19 or the Probability of Disease in the Population of Caucasians in Eastern Siberia [0.03%]
rs657152 基因多态性与东西伯利亚高加索人新冠病毒载量及感染风险无相关性
E A Orlova,O B Ogarkov,P A Khromova et al.
E A Orlova et al.
Cross-replicating associations with rs657152 at the 9q34.2c locus and rs11385942 at the 3p21.31 locus found in patients with severe COVID-19 in the Caucasian population require the study of the discovered phenomenon in various populations, ...
Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection [0.03%]
与COVID-19冠状病毒感染发病相关的遗传风险因素分析
O S Glotov,A N Chernov,S G Scherbak et al.
O S Glotov et al.
The COVID-19 coronavirus pandemic has spread to 215 countries around the world and caused tens of millions of infections and more than a million deaths worldwide. In the midst of COVID-19 infection, it is extremely important to identify new...
A N Kucher,N P Babushkina,A A Sleptcov et al.
A N Kucher et al.
In 2019, the SARS-CoV-2 beta-coronavirus, which caused a pandemic of severe acute respiratory viral infection COVID-19 (from COronaVIrus Disease 2019), was first detected. The susceptibility to SARS-CoV-2 and the nature of the course of the...
Drosophila melanogaster as a model for studying the function of animal viral proteins [0.03%]
模式动物病毒蛋白功能研究的果蝇模型
L V Omel&#x;yanchuk,O S Yudina
L V Omel&#x;yanchuk
Studies in which Drosophila melanogaster individuals carrying transgenes of animal viruses were used to analyze the action of animal viral proteins on the cell are reviewed. The data presented suggest that host specificity of viruses is det...
Expression of anti-tumor recombinant IgG- and IgE-like genes in eukaryotic cells [0.03%]
在真核细胞中表达抗肿瘤的重组IgG和IgE样基因
O L Polanovsky,S V Lukash,O A Stremovskiy et al.
O L Polanovsky et al.
The tandem of humanized variable VL and VH genes (ScFv fragment 4D5) possessing a high affinity to the HER-2/neu oncogene (the epidermal growth factor receptor expressed in many types of human tumors) was attached through a flexible linker ...
D Marinkovic,S Cvjeticanin
D Marinkovic
The study of Balkan endemic nephropathy (BEN) in the affected localities of southern Serbia shows population-genetic difference between samples of BEN affected individuals and control group consisting of non-affected individuals from the sa...
S A Gostimsky,Z G Kokaeva,F A Konovalov
S A Gostimsky
The authors' studies on the organization and variation of plant genome with the use of molecular markers are briefly reviewed with special emphasis on random amplified polymorphic DNA (RAPD), inter simple sequence repeat (ISSR), sequence ch...
Genes for biosynthesis of butenolide-like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production [0.03%]
产生类似butenolide信号分子的基因簇在草地链霉菌中调控莫尼令生物合成的作用机制研究
H Mutenko,R Makitrinskyy,O Tsypik et al.
H Mutenko et al.
Moenomycins (Mm) - phosphoglycolipid compounds produced by Streptomyces ghanaensis ATCC14672 - are considered a promising model for development of novel class of antibiotics. In this regard it is important to generate Mm overproducing strai...