[A real-world study of clinical cure in children with HBeAg-positive chronic hepatitis B from the Guangxi region] [0.03%]
[广西地区HBsAg、HBeAg阳性和HBsAg阳性、HBeAg阴性慢性乙型肝炎患儿的临床治愈研究]
R Y Lyu,J H Tian,S M Huang et al.
R Y Lyu et al.
[Clinical characteristics and follow-up in children with Alagille syndrome] [0.03%]
儿童Alagille综合征的临床特征及随访结果分析
W W Liu,X M Zhong,P Wang et al.
W W Liu et al.
Objective: To investigate the clinical and genetic features and follow-up outcomes in children with Alagille syndrome (ALGS). Methods: A retrospective cohort study was conducted. Clinical data from 24 children diagnosed with ALGS treated at...
[Exploring the protective effects and mechanisms of HYX1-derived exosomes on acute liver failure based on disulfidptosis signaling] [0.03%]
基于二硫键分解信号的HYX1来源外泌体对急性肝衰竭保护作用及机制探索
Q Yang,H X Tang,X X Liu et al.
Q Yang et al.
Objective: To explore the protective effect and molecular mechanism of human liver stem cell line HYX1-derived exosomes (HYX1-Exos) on acute liver failure (ALF) based on disulfidptosis signaling. Methods: Healthy male BALB/c mice were intra...
[Study on the establishment, assessment, and drug sensitivity testing for intrahepatic cholangiocarcinoma organoid models based on the suspension culture method] [0.03%]
基于悬浮培养法的肝内胆管癌类器官模型的建立、鉴定及药敏检测研究
Y H Su,W Huang,C Yu et al.
Y H Su et al.
Objective: To investigate the feasibility of establishing intrahepatic cholangiocarcinoma (ICC) organoid models based on the suspension culture method. Methods: Fresh tumor tissue specimens were prepared from six patients with intrahepatic ...
[Diagnostic value and clinical significance of matrix metalloproteinase-7, gamma-glutamate transferase, and liver stiffness measurement with ultrasound elastography in children with biliary atresia] [0.03%]
金属基质素酶-7、γ-谷氨酰转移酶及超声 elastography 评估肝硬度检测在胆道闭锁患儿中的诊断价值及临床意义
J M Zhang,Y L Sun,Q Z Li et al.
J M Zhang et al.
Objective: To investigate the diagnostic value and clinical significance of matrix metalloproteinase-7 (MMP-7), gamma-glutamyl transferase (GGT), and liver stiffness measurement (LSM) with ultrasound elastography in children with biliary at...
[ATPase H+ transporter expression with prognosis in hepatocellular carcinoma] [0.03%]
肝细胞癌中ATP酶H+转运体的表达与预后关系的研究
Q Yuan,Y Q Jin,Y X Cao et al.
Q Yuan et al.
Objective: To investigate the expression level of ATPase H+ transporting accessory protein 1 (ATP6AP1) in hepatocellular carcinoma (HCC) lines and its effect on cell proliferation and migration, providing a new target for the treatment of H...
[Interferon-α induces disulfidptosis occurrence in human liver cancer cells] [0.03%]
干扰素诱导人肝癌细胞中二硫键介导的蛋白质降解发生
X Y Bi,J Zhang,L H Xu et al.
X Y Bi et al.
Objective: To investigate the potential molecular regulatory mechanism of interferon-α (IFN-α)-induced disulfidptosis occurrence in human liver cancer cells. Methods: Glucose starvation and IFN-α treatment models were constructed using h...
[Precise clinical classification of metabolic associated fatty liver disease] [0.03%]
[代谢相关脂肪性肝病的精准临床分类]
W R Su,J J Ding,Q Pan et al.
W R Su et al.
Metabolic associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide, and its significant clinical and pathophysiological heterogeneity poses a serious challenge to traditional "one-size-fits-all" diagnostic a...
[Research progress on the mechanisms and optimization strategies of mesenchymal stem cell-derived exosomes in the treatment of liver diseases] [0.03%]
间充质干细胞外泌体治疗肝病的机制及优化策略研究进展
X R Li,B Niu,L Y Zhang
X R Li
As an emergent acellular therapeutic tool, mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated good application prospects in the prevention and treatment of liver diseases. MSC-Exos exhibit a lower immunogenicity and tumorig...
[Advances in the construction and application of a novel liver organoid model for hepatitis B virus infection] [0.03%]
新型乙型肝炎病毒感染肝器官芯片模型的构建及应用研究进展
H Li,K H Xiang
H Li
Hepatitis B virus (HBV) infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma, posing a threat to human health, yet its specific pathogenic mechanisms have not been fully elucidated. Organoid models have sho...