[Exploring the protective effects and mechanisms of HYX1-derived exosomes on acute liver failure based on disulfidptosis signaling] [0.03%]
基于二硫键分解信号的HYX1来源外泌体对急性肝衰竭保护作用及机制探索
Q Yang,H X Tang,X X Liu et al.
Q Yang et al.
Objective: To explore the protective effect and molecular mechanism of human liver stem cell line HYX1-derived exosomes (HYX1-Exos) on acute liver failure (ALF) based on disulfidptosis signaling. Methods: Healthy male BALB/c mice were intra...
[Study on the establishment, assessment, and drug sensitivity testing for intrahepatic cholangiocarcinoma organoid models based on the suspension culture method] [0.03%]
基于悬浮培养法的肝内胆管癌类器官模型的建立、鉴定及药敏检测研究
Y H Su,W Huang,C Yu et al.
Y H Su et al.
Objective: To investigate the feasibility of establishing intrahepatic cholangiocarcinoma (ICC) organoid models based on the suspension culture method. Methods: Fresh tumor tissue specimens were prepared from six patients with intrahepatic ...
[Diagnostic value and clinical significance of matrix metalloproteinase-7, gamma-glutamate transferase, and liver stiffness measurement with ultrasound elastography in children with biliary atresia] [0.03%]
金属基质素酶-7、γ-谷氨酰转移酶及超声 elastography 评估肝硬度检测在胆道闭锁患儿中的诊断价值及临床意义
J M Zhang,Y L Sun,Q Z Li et al.
J M Zhang et al.
Objective: To investigate the diagnostic value and clinical significance of matrix metalloproteinase-7 (MMP-7), gamma-glutamyl transferase (GGT), and liver stiffness measurement (LSM) with ultrasound elastography in children with biliary at...
[ATPase H+ transporter expression with prognosis in hepatocellular carcinoma] [0.03%]
肝细胞癌中ATP酶H+转运体的表达与预后关系的研究
Q Yuan,Y Q Jin,Y X Cao et al.
Q Yuan et al.
Objective: To investigate the expression level of ATPase H+ transporting accessory protein 1 (ATP6AP1) in hepatocellular carcinoma (HCC) lines and its effect on cell proliferation and migration, providing a new target for the treatment of H...
[Interferon-α induces disulfidptosis occurrence in human liver cancer cells] [0.03%]
干扰素诱导人肝癌细胞中二硫键介导的蛋白质降解发生
X Y Bi,J Zhang,L H Xu et al.
X Y Bi et al.
Objective: To investigate the potential molecular regulatory mechanism of interferon-α (IFN-α)-induced disulfidptosis occurrence in human liver cancer cells. Methods: Glucose starvation and IFN-α treatment models were constructed using h...
[Precise clinical classification of metabolic associated fatty liver disease] [0.03%]
[代谢相关脂肪性肝病的精准临床分类]
W R Su,J J Ding,Q Pan et al.
W R Su et al.
Metabolic associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide, and its significant clinical and pathophysiological heterogeneity poses a serious challenge to traditional "one-size-fits-all" diagnostic a...
[Research progress on the mechanisms and optimization strategies of mesenchymal stem cell-derived exosomes in the treatment of liver diseases] [0.03%]
间充质干细胞外泌体治疗肝病的机制及优化策略研究进展
X R Li,B Niu,L Y Zhang
X R Li
As an emergent acellular therapeutic tool, mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated good application prospects in the prevention and treatment of liver diseases. MSC-Exos exhibit a lower immunogenicity and tumorig...
[Advances in the construction and application of a novel liver organoid model for hepatitis B virus infection] [0.03%]
新型乙型肝炎病毒感染肝器官芯片模型的构建及应用研究进展
H Li,K H Xiang
H Li
Hepatitis B virus (HBV) infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma, posing a threat to human health, yet its specific pathogenic mechanisms have not been fully elucidated. Organoid models have sho...
[Exploring the research on the molecular mechanisms of autoimmune liver diseases] [0.03%]
[探究自身免疫性肝病分子机制的研究]
Y Q Liu,X W Jiang,Y Li et al.
Y Q Liu et al.
Autoimmune liver diseases include subtypes such as autoimmune hepatitis and primary biliary cholangitis, which are caused by abnormal immune system attacks on hepatocytes or bile ducts. This article reviews their molecular mechanisms from t...
[The value of the nutritional assessment index or score in prognostic evaluation for patients with liver cancer] [0.03%]
营养评估指数或评分在肝癌预后评价中的价值
J C Shen,J Kang,Y Lei et al.
J C Shen et al.
Liver cancer is a common malignant tumor and a leading cause of mortality worldwide, which currently lacks standardized prognostic assessment criteria. Nutritional factors are crucial for patients with liver cancer prognosis, and there are ...