CRISPR-Cas13a mediated nanosystem for attomolar detection of canine parvovirus type 2 [0.03%]
基于CRISPR-Cas13a的纳米系统实现attolocal浓度犬细小病毒Ⅱ型检测
Haroon Khan,Adeel Khan,Yufeng Liu et al.
Haroon Khan et al.
Canine parvovirus type 2 (CPV-2) infection is the most lethal disease of dogs with higher mortality in puppies worldwide. In today's world, dogs are an integral part of our communities as well as dogs breeding and rearing has become a lucra...
Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives [0.03%]
三唑金催化A3偶联反应合成2，4-二取代喹啉类化合物
Fusong Zhang,Qi Lai,Xiaodong Shi et al.
Fusong Zhang et al.
A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, thi...
Natasha D Sheybani,Hu Yang
Natasha D Sheybani
The eye is a highly complex, yet readily accessible organ within the human body. As such, the eye is an appealing candidate target for a vast array of drug therapies. Despite advances in ocular drug therapy research, the focus on pediatric ...
Mechanism and Reactivity of Rh-Catalyzed Intermolecular [5+1] Cycloaddition of 3-Acyloxy-1,4-Enyne (ACE) and CO: A Computational Study [0.03%]
3-酰氧基-1,4-炔烯(ACE)和CO的铑催化分子间[5+1]环加成反应机理与活性的计算研究
Xiao-Na Ke,Casi M Schienebeck,Chen-Chen Zhou et al.
Xiao-Na Ke et al.
The first theoretical study on the mechanism of [RhCl(CO)2]2-catalyzed [5 + 1] cycloadditions of 3-acyloxy-1,4-enyne (ACE) and CO has been performed using density functional theory (DFT) calculations. The effect of ester on reactivity of th...
Song Qing Wang,Omar A Ibrahimi,Pan Li et al.
Song Qing Wang et al.
Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH(3)CN afforded the corresponding nucleophilic h...